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In 1 tablet of 5 mg of Norethisteronum of acetate. Lactoses monohydrate, corn starch, polividon, talc, magnesium stearate as auxiliary components.
Tablets of 10 mg and 5 mg.
Pharmacodynamics and pharmacokinetics
Synthetic derivative progesterone — hormone of a yellow body. Possesses progesteronopodobny activity and shows action at intake. Active agent of drug causes transition of a mucous uterus to a secretory phase. In 3 days after the termination of treatment there is menstrualnopodobny bleeding.
Apply at gynecologic diseases which are connected with insufficiency of a yellow body, disturbances of a menstrual cycle. Affecting an endometria, causes a stop of dysfunctional bleedings. Reduces excitability of muscles of a uterus and pipes. Gestagenny action is shown also in oppression of gonadotropic hormones.
At intake the maximum concentration in blood is defined in 1-2 hours, and then two-phase decrease in concentration is noted.
Indications to use
- dysfunctional uterine bleedings;
- amenorrhea (primary or secondary);
- dishormonal mastopathy;
- premenstrual syndrome;
- endometria hyperplasia;
- menopausal syndrome;
- contraception at a lactation;
- suppression of a lactation.
- abnormal liver functions;
- thrombophlebitis, tendency to fibrinferments;
- thromboembolisms (in the anamnesis);
- liver tumors;
- herpes (in the anamnesis);
- uterine bleedings of not clear genesis;
- idiopathic jaundice;
- hormonedependent tumors of generative organs and mammary gland.
- increased fatigue;
- breakthrough uterine bleedings;
- nagrubaniye of mammary glands;
- allergic reactions;
- changes of body weight.
Primolyut-Nor, application instruction (Way and dosage)
The pill Primolyut-Nor is taken inside, on 1–2 tablets, after food, washing down with liquid.
Schemes of treatment differ at various diseases.
Dysfunctional uterine bleedings — 5 mg twice a day till 10 days in a row. In the first three days bleedings stop. If they do not stop treatment prolong before complete cessation of bleeding.
At menorrhagias which are connected with insufficient production of progesterone in a lyuteinovy phase drug is used in the second half of a cycle (from 19 to the 26th day) — 5 mg twice a day. On doctor's orders sometimes accept during three cycles in a row in the same days.
The amenorrhea (primary and secondary) — a dosage is established individually.
Premenstrual syndrome — 5 mg twice a day in the second half of a cycle (from 19 to the 26th day) Reception repeat several cycles in a row.
For change of term of arrival of periods — 5 mg once a day in 3 days prior to expected periods and no more than 14 days. On the reception termination menstrual bleeding comes for the 2nd day.
Endometriosis — 5 mg or 10 mg twice a day from 5 in the afternoon a cycle. Treatment is carried out by 4-6 months. Increase of a dose to 10-20 mg twice a day is possible. At disappearance of the bleedings caused by endometriosis low doses are used.
Even at accidental reception of the doses exceeding therapeutic several times acute toxicity of drug is not revealed.
Terms of sale
According to the recipe.
Temperature is up to 25 °C.
Period of validity
About Primolutum Nora
Relative deficit of progesterone in an organism of the woman causes development of proliferative processes of an endometria therefore these states are the indication to use of progestogens among which there is Norcolutum, Orgametril, Primolutum holes.
Appointment is justified them also at a hysteromyoma combination to a hyperplasia of an endometria and an adenomyosis at patients of the premenopauzalny period, on condition of continuous supervision. The most effective for treatment of an adenomyosis are gonadotrophin-rileasing-hormone agonists, however their high cost does not allow to apply them rather widely. In this regard much appoint progestogens which are applied also at treatment of PMS. All this has reflection in responses of patients, however most often drug or its analogs was applied at dysmenorrheas (long monthly.) Reception them in the second phase MTs does not exert impact on an ovulation, suppresses proliferative processes and reduces a sokratitelny uterine activity.
- "… Monthly plentiful and for 11 days, I accept the second day on doctor's orders, monthly practically ended".
- "… An endometria hyperplasia, I accept this drug. Monthly are normalized, not plentiful".
- "… Hyperplasia of an endometria and small fibromyoma. The third month according to the scheme I accept Primolutum - Holes, I transfer well, monthly not plentiful. In 2 months I will make ultrasonography".
- "… I have a fast-growing leiomyoma, a hyperplasia of an endometria and polyps. Primolyut-Nor and Duphaston, but treatment without results accepted — the uterus increases. Offer operation".
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