Progesterone

Прогестерон Drug photo

The description is actual on 10.12.2014

  • Latin name: Progesterone
  • ATH code: G03DA04
  • Active ingredient: Progesterone (Progesterone)
  • Producer: JSC Dalkhimfarm, Russia JSC Farmak, Ukraine CIAO "Biofarm", Ukraine

Structure

Progesterone of 1% of injection solution contains in 1 ml 0,01 grams of active ingredient, and also benzyl benzoate (Benzylii benzoas) and the refined olive/peach oil (Oleum Olivarum/Oleum Persicorum).

Progesterone of 2,5% 0,025 grams of active ingredient, benzyl benzoate (Benzylii benzoas) and the refined olive/peach oil (Oleum Olivarum/Oleum Persicorum) are a part of one milliliter of injection solution.

Progesterone of 1% and 2,5% is issued in ampoules on 1 ml packaged in packagings on 5 or 10 pieces.

The composition of gel and capsules varies depending on what pharmaceutical company lets out these dosage forms.

Release form

Today in drugstores is on sale:

  • Progesterone in tablets for oral administration and in capsules for intravaginalny use;
  • Progesterone in ampoules in the form of injection solution in peach or olive oil;
  • Gel Progesterone for external use.

Pharmacological action

Progestagennoye. Active agent of drug belongs to kliniko-pharmacological group of "Gestagena" and takes part in functioning of the hypothalamus-hypophysis-ovaries system.

Pharmacodynamics and pharmacokinetics

Progestogen is a steroid hormone which in an organism is produced by a yellow body of ovaries.

The mechanism of effect of drugs of progesterone is connected with their ability to interact with specific gestagenny receptors which are located on a surface of target cells.

Contacting them, substance gets into a cell kernel, activates deoxyribonucleic acid and stimulates RNA synthesis.

Influence on an organism of the woman is that drug:

  • stimulates transition of an endometria (a mucous layer of an internal mucous membrane which covers a body of the womb) from a proliferative phase which matches with ovulatory and follicular phases of an ovarian cycle, in secretory;
  • creates optimal conditions for implantation of an embryo, reduces sensitivity of a uterus and uterine tubes to action of oxytocin and renders tokolitichesky effect;
  • stimulates lipases of lipoproteins;
  • increases fatty stocks of an organism;
  • promotes increase of level of the induced and basal (background) insulin, stimulates intracellular utilization of glucose;
  • strengthens cumulation of a glycogen in a liver;
  • stimulates synthesis with bark of adrenal glands of mineralokortikosteroidny hormone of Aldosteronum;
  • provokes a hypoazotemia;
  • increases allocation with urine nitrogen of the containing exchange products;
  • suppresses development of a number of hypothalamic release factors of a lyuteotropin (LG) and follicle-stimulating hormone (FSG) and, respectively, biosynthesis of hypophyseal gonadotropic hormones;
  • reduces permeability of a capillary wall in fabrics of chest glands;
  • reduces puffiness of a menstrual cycle of a connective tissue framework, dependent on a phase;
  • suppresses proliferative and mitotic activity of epithelial fabric of channels (in a case when progesterone is applied in the form of gel).

At oral administration, intravaginalny use of drug in capsules, administration of injection solution under skin and in a muscle, substance it is quickly absorbed. At application on skin in the form of gel it is almost not absorbed and does not get to a system blood stream.

Plasma concentration at reception of a tablet is maximum inside it is noted in 1-3 hours, at intravaginalny application this indicator is reached in 2–6 h.

Progesterone is characterized by ability to contact proteins for 96–99% (mainly with albumine (approximately for 50–54%) and for 43-48% with kortikosteroidsvyazyvayushchy globulin).

In a liver substance biotransformirutsya in inactive metabolites (mainly in pregnandiol and pregnanolon).

From 50 to 60% of substance eliminirutsya by kidneys, more than 10% — with bile; the products of a metabolization of progesterone which are excreted with bile are removed with contents of intestines and can be exposed to enterohepatic recirculation.

Indications to use

Progesterone: for what it is necessary in the form of capsules for oral administration?

Reception of capsules is shown at a premenstrual syndrome and if the fibrosing adenosis (fibrous cystic disease) is diagnosed for the woman.

As a gestagenny component drug is appointed at RHT (replacement hormonal therapy) during the period preceding a menopause, directly at a climax (including if a climax premature), and also in the post-menopausal period.

Capsules for intravaginalny introduction: indications to use

Capsules for intravaginalny use are shown:

  • in need of appointment to the woman of ZGT in case of the dysfunction of ovaries which is followed by lack of progesterone (donorship of oocytes);
  • for maintenance of a lyuteinovy phase during preparation for EKO;
  • for maintenance of a lyuteinovy phase in the induced or spontaneous menstrual cycle.

In the preventive purposes drug is appointed for the prevention of the usual and menacing misbirth caused by gestagenny insufficiency; at endocrine infertility; for the prevention of development of a fibromyoma and endometriosis.

Indications to use of Solutio oleosa

As progesterone causes monthly (if their delay is connected with deficit of this hormone), it is appointed for different correction of disturbances of a menstrual cycle.

So, purpose of Solutio oleosa is reasonable at an amenorrhea (absence of menstrual bleedings throughout several cycles) and an oligomenorrhea (that is at a delay of menstrual bleedings more than for 40 days).

Besides, pricks are appointed at:

  • to the algomenorrhea (painful monthly) connected with insufficiency of gonads;
  • anovulatory metrorrhagia (the uterine bleedings which are not connected with an ovulation);
  • endocrine infertility (including caused by insufficiency of a yellow body);
  • to threat of a misbirth;
  • diagnostic procedures which purpose is determination of level of secretion estrogenovyo +.

Progesterone at a delay of monthly can be applied both in the tableted form, and in pricks. However more often nevertheless appoint injection solution as the effect after it is swept up much quicker, than after reception of tablets.

Indications to gel use
Applications with use of Progesterone in the form of gel are appointed at a mastalgiya and a mastopathy.

Intravaginalny applications with gel are shown for treatment of the secondary amenorrhea connected with deficit of progesterone, and also in reproductive programs if the woman needs to fill a lack of progesterone at donorship of oocytes.

Contraindications

All dosage forms of Progesterone are contraindicated:

  • at hypersensitivity to drug components;
  • in the presence of serious violations of function of kidneys and/or hepatic function;
  • if hepatitis is diagnosed for the patient;
  • at an acute form of an inflammation of venous walls, and also at the thromboembolic diseases proceeding in an acute form;
  • to patients at whom the risk of formation of blood clots is increased;
  • vaginal (vulval) bleedings of not clear nature;
  • cancelled abortion;
  • incomplete abortion;
  • porphyrinic illness.

Additional contraindications to purpose of Solutio oleosa are:

  • existence of a malignant tumor of chest gland or generative organs (at a carcinoma of a mammary gland of an exception make cases when progesterone is appointed as a part of complex therapy);
  • pregnancy (since 14th week).

Side effects

Treatment by drugs of progesterone can become the reason of development of allergic reactions.

Action on an organism of the woman of drug in the form of capsules in some cases is followed:

  • drowsiness increase;
  • the coming dizzinesses arising 1-3 hours later after reception of a tablet;
  • different disturbances of a menstrual cycle (for example, reduction of its duration or emergence of intermediate bleedings).

The most frequent side effects of pricks:

  • acute obstruction of a gleam of blood vessels blood clot;
  • thrombophlebitis (the thrombosis which is followed by an inflammation of a venous wall);
  • thrombosis of blood vessels of a retina;
  • increase of indicators of arterial pressure;
  • emergence of hypostases;
  • the chronic cholecystitis which is characterized by formation of concrements in a gall bladder (calculous cholecystitis);
  • the increased drowsiness;
  • headaches;
  • apathy;
  • vision disorders;
  • hair loss (alopecia);
  • decrease in a libido;
  • hirsutism (growth of hair at the woman on man's type);
  • attacks of nausea and vomiting;
  • deterioration in appetite and, as a result, decrease in body weight;
  • disturbances of a menstrual cycle;
  • cholestatic hepatitis;
  • depression;
  • dysphoria (disorder of gender identity);
  • the release of milk which is not connected with feeding of the child a breast from mammary glands (galactorrhoea);
  • increase, morbidity and intensity of mammary glands;
  • local reactions (reddening of an integument and morbidity in the place of an injection).

The instruction on Progesterone

Progesterone pricks: application instruction

Injections of Progesterone are given in a muscle or under skin.

At dysfunctional uterine bleedings daily introduction for 6-8 days of 0,5-1,5 ml of one-percentage solution is shown. If the patient was exposed to procedure of a scraping of a cavity of the uterus, the course of pricks is begun in 18-20 days.

If it is impossible to carry out a scraping, administration of drug even in a bleeding time is allowed. When using Progesterone in a bleeding time the last can temporarily amplify (usually for 3-5 days).

For this reason for patients with moderately expressed or heavy forms of anemia it is recommended to pour 0,2-0,25 l of donor blood previously. At the stopped bleeding it is not necessary to interrupt a course of treatment before 6 days. If bleeding did not stop after 6-8 days of treatment, to continue administration of solution it is considered inexpedient.

At algodismenory (painful monthly) treatment is begun in 6-8 days prior to the beginning of periods. Daily introduction for 6-8 days from 0,5 to 1 ml of one-percentage solution is shown to patients. The course of treatment is allowed to be repeated several times.

In the preventive purposes for the prevention of a misbirth daily or every other day enter from 0,5 to 2,5 ml of one-percentage solution. Injections continue to do to a total disappearance of the menacing symptoms. At a usual abortion the drug should be administered till IV month of pregnancy.

The maximum single and daily dose to adult patients at administration of Progesterone in a muscle makes 0,025 g.

Progesterone for a call of monthly: how to prick at a delay of monthly

At a hypogonadism, an amenorrhea, and also for calling monthly in case of their delay treatment is begun with purpose of drugs of oestrogenic action. The purpose of therapy is achievement of sufficient proliferation of cells of an endometria. Upon completion of a course using drugs of oestrogenic action to the patient appoint Progesterone pricks.

Treatment assumes introduction daily on 0,5 or every other day on 1 ml of one-percentage Solutio oleosa (Progesterone of 2,5% for a call of monthly can be in some cases appointed). As a rule, from 5 to 10 injections are required.

The instruction on Progesterone in tablets and in the form of gel

Pill is taken inside (without becoming attached by the time of meal) or applied intravaginalno, gel is used as local means. The dosing mode, an optimum dosage form and duration of treatment are defined depending on indications and features of a course of a disease.

As a rule, the daily dose makes from 200 to 400 mg of progesterone. For maintenance of a lyuteinovy phase at EKO the dose equal to 600 mg of progesterone, with frequency rate of uses 3 times a day is shown to the patient (on 200 mg every 8 hours).

For one application 2,5 g of gel are required (that is equivalent to 25 mg of progesterone). Gel apply by means of the special applicator doser on skin of mammary glands daily one or twice a day (before full absorption) or in the second phase of a menstrual cycle (from 16 to the 25th day). Treatment is carried usually out during 3 cycles.

The repeated course is possible according to indications.

Overdose

At overdose by Progesterone the risk of development of the side effects described above increases, and their expressiveness at the same time amplifies. At emergence of undesirable symptoms use of drug is stopped. After disappearance of side effects treatment is continued, but with use of smaller doses.

Overdose by drug in the form of gel is considered improbable because its system absorption is extremely insignificant.

Interaction

Reduces intensity of effect of the anabolic steroid drugs, oxytoxic drugs (that is the means stimulating a sokratitelny uterine activity) which are synthesized in a front share of a hypophysis of gonadotropic hormones.
Reduces lactogenic effect of oxytocin.

At simultaneous use with diuretic drugs, bromkriptiny; the drugs reducing the increased arterial pressure; system coagulants, immunosuppressors Progesterone strengthens effect of these medicines.

At administration of drug in a combination with barbiturates reduction of its pharmacological activity is noted.

Progesterone reduces efficiency of anticoagulants.

Terms of sale

According to the recipe.

Storage conditions

To store in the dry dark place at a temperature from 15 to 25 degrees Celsius. To protect from children.

Period of validity

Drug is good for use during 5 flyings from the moment of release.

Special instructions

With care and under a constant control apply at heart diseases and vessels, the epilepsy slight or moderately expressed renal failures, to treatment of diabetics, the patients suffering from bronchial asthma and migraine.

Also with care appoint Progesterone and to the patients having mental disturbances in the anamnesis. At emergence of the first symptoms of a depression treatment is stopped. Also it is necessary to pay attention and to precursory symptoms of development of a thromboembolism. Their emergence is a reason for drug withdrawal.

Patients with a diabetes mellitus during treatment by Progesterone should control constantly indicators of content of glucose in blood.

As steroid hormones are metabolized in a liver, do not appoint Progesterone to patients with abnormal liver functions.

Treatment by drugs of progesterone can be followed by easing of concentration of attention therefore it is necessary to be careful at control of vehicles and occupations by other types of activity which demand the high speed of psychomotor reactions or bear potential threat to health and life.

Long use of the raised doses of Progesterone can provoke the termination of periods.

Drug in the form of gel put, without rubbing it in skin of mammary glands and without massing them. After putting cream it is not necessary to be under direct sunshine.

Analogs

Coincidence on the ATH code of the 4th level:

Progesterone the containing drugs are Utrozhestan, Iprozhin, Kraynon, Pradzhisan, Prozhestozhel, Endometrin. Multicomponent analog of drug — vaginal capsules Triozhinal.

Zdravzona

  • Pregnenoldione kapronat 12,5% solution for injections of 1 ml No. 10 ampulydalkhimfarm joint stock company
  • Progesterone of 2,5% solution for injections of 1 ml No. 10 ampulydalkhimfarm joint stock company
  • Progesterone of 1% solution for injections of 1 ml No. 10 ampulydalkhimfarm joint stock company
  • Kraynon (progesterone of 8%) gel vaginal 1,125g No. 15 applicators

Drugstore of IFC

  • Progesterone solution for in masl. 2.5% of amp of 1 ml No. 10, Dalkhimfarm (Khabarovsk) Russia
  • Kraynon (progesterone of 8%) gel of vaginas. 1.125g No. 15 applik., Feet Lab.Velikobritaniya
  • Pregnenoldione Kapr. solution for in.masl. 12.5% of amp of 1 ml No. 10, Dalkhimfarm (Khabarovsk) Russia
  • Progesterone solution for in masl. 1% of amp of 1 ml No. 10, Dalkhimfarm (Khabarovsk) Russia
to show still

Apteka24

  • Pregnenoldione of a kapronatbiofarm (Ukraine, Kiev)
  • Progesteronbiofarm (Ukraine, Kiev)
  • Progesteronbiofarm (Ukraine, Kiev)

Paniapteka

  • Progesterone solution masl. for infection. 1% of amp. 1 ml No. 10biofarma
  • Pregnenoldione kapronat solution for infection. 12.5 amp %. 1 ml No. 10
  • Progesterone solution masl. for infection. 1% of amp. 1 ml No. 10biofarma

BIOSPHERE

  • Progesterone 2,5%/1 of ml No. 10 solution for in.olivk. masl. Biofarm (Ukraine)
  • Pregnenoldione kapronat 12,5%/ml No. 10 solution for in.olivk. masl. Biofarm (Ukraine)
  • Progesterone 1%/1 of ml No. 10 solution for in.olivk. masl. Biofarm (Ukraine)
to show still
Section: Hormonal
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Progesterone surely consult with the attending physician.