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Propylthiouracil, monohydrate of lactose, corn starch, silicon dioxide colloid, gelated starch, povidone, magnesium stearate.
Tablets of 50 mg of a round form biconvex, white color in polyethylene bottles in a cardboard box No. 20.
Pharmacodynamics and pharmacokinetics
Drug blocks thyroid peroxidase and suppresses process of transformation of the ionized iodine into elementary iodine (an active form). Its ekstratireoidny action includes process of braking of transformation of a tetrayodtironin in triiodothyronine. Propitsil weakens symptomatology of a thyrotoxicosis and reduces the sizes of a thyroid gland which growth is caused by lowering of concentration of its hormones in blood in response to development increase by a hypophysis of thyritropic hormone.
Drug is quickly absorbed from a gastrointestinal tract. It is metabolized in a liver. It is removed with urine within a day partially in not changed look.
Indications to use
- In the course of preparation for removal of a thyroid gland;
- In the course of treatment by a radioiodine.
High sensitivity to drug, a hypothyroidism, an agranulocytosis, a liver failure, a leukopenia, cirrhosis, hepatitis in an active form, to patients at whom in the anamnesis the expressed side effects of drug took place (damages of a liver, an agranulocytosis).
In the course of treatment by drug the enlargement of the thyroid gland, an itch, nausea, vomiting, alopecias, dizzinesses, anorexia, neuromuscular frustration, paresthesias, arthralgias, the small tortoiseshell, an enanthesis, disturbances of an erythrogenesis can be observed.
Propitsil, application instruction (Way and dosage)
To accept inside, swallowing entirely, washing down with water, every 7-8 hours. The initial medical dose for adults and children after 12 flyings makes 75–100 mg a day (1,5-2 tablets). A maintenance dose — 25–150 mg a day (0,5 — 3 tablets). At a heavy current and after loading iodine it is necessary to increase a daily dose to 300–600 mg which is accepted to 4-6 receptions.
The newborn at a thyrotoxicosis appoint drug in a dosage on 5–10 mg/kg/days, divided into 3 receptions. In the absence of effect the dose increases by 1,5–2 times. The supporting dosage — 3–4 mg/kg/days. To children of 6 — 10 years appoint 50–150 mg a day, the supported dose — 25–50 mg a day. Duration of treatment of a thyrotoxicosis varies over a wide range and 1,5–2 years can proceed. In the course of training of the patient for radiation exposure or an operative measure the dosage and duration of reception of Propitsil is defined individually.
Acute intoxication at treatment by drug was not observed, however, administration of drug in the doses exceeding therapeutic throughout the long period can lead to development of a craw and a hypothyroidism with inherent symptomatology.
At treatment by drug according to the scheme "block and substitute" together with thyroxine, Propitsil's dosage needs to be increased. At the previous or concomitant use of iodinated HP or radiopaque substances the thyreostatic effect of Propitsil decreases.
Terms of sale
According to the recipe.
At a temperature not above 25 °C.
Period of validity
Propitsil at pregnancy
Treatment by Propitsil during pregnancy has to be carried out under strict supervision of the specialist (the indicator of thyrotropin has to be lower than norm, indicators of hormones of a thyroid gland — at the upper bound of norm). For the purpose of prevention of an abortion and development in a fruit of a hypothyroidism and a craw, Propitsil's dosage has to be the lowest. At development of a diffusion toxic craw during pregnancy, Propitsil is used as monotherapy drug. B the lactation period Propitsil belongs to choice drugs. The subsequent supervision over the child for the purpose of early identification of cases of a hypothyroidism is necessary.
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