Пропицил Drug photo

The description is actual on 07.07.2016

  • Latin name: Propicil
  • ATH code: H03BA02
  • Active ingredient: Propylthiouracil (Propylthiouracil)
  • Producer: Admeda Arzneimittel (Germany); HAUPT PHARMA BERLIN Gmb.H (Germany); Solvay Pharma (Netherlands)


Propylthiouracil, monohydrate of lactose, corn starch, silicon dioxide colloid, gelated starch, povidone, magnesium stearate.

Release form

Tablets of 50 mg of a round form biconvex, white color in polyethylene bottles in a cardboard box No. 20.

Pharmacological action


Pharmacodynamics and pharmacokinetics


Drug blocks thyroid peroxidase and suppresses process of transformation of the ionized iodine into elementary iodine (an active form). Its ekstratireoidny action includes process of braking of transformation of a tetrayodtironin in triiodothyronine. Propitsil weakens symptomatology of a thyrotoxicosis and reduces the sizes of a thyroid gland which growth is caused by lowering of concentration of its hormones in blood in response to development increase by a hypophysis of thyritropic hormone.


Drug is quickly absorbed from a gastrointestinal tract. It is metabolized in a liver. It is removed with urine within a day partially in not changed look.

Indications to use

  • Thyrotoxicosis;
  • In the course of preparation for removal of a thyroid gland;
  • In the course of treatment by a radioiodine.


High sensitivity to drug, a hypothyroidism, an agranulocytosis, a liver failure, a leukopenia, cirrhosis, hepatitis in an active form, to patients at whom in the anamnesis the expressed side effects of drug took place (damages of a liver, an agranulocytosis).

Side effects

In the course of treatment by drug the enlargement of the thyroid gland, an itch, nausea, vomiting, alopecias, dizzinesses, anorexia, neuromuscular frustration, paresthesias, arthralgias, the small tortoiseshell, an enanthesis, disturbances of an erythrogenesis can be observed.

Propitsil, application instruction (Way and dosage)

To accept inside, swallowing entirely, washing down with water, every 7-8 hours. The initial medical dose for adults and children after 12 flyings makes 75–100 mg a day (1,5-2 tablets). A maintenance dose — 25–150 mg a day (0,5 — 3 tablets). At a heavy current and after loading iodine it is necessary to increase a daily dose to 300–600 mg which is accepted to 4-6 receptions.

The newborn at a thyrotoxicosis appoint drug in a dosage on 5–10 mg/kg/days, divided into 3 receptions. In the absence of effect the dose increases by 1,5–2 times. The supporting dosage — 3–4 mg/kg/days. To children of 6 — 10 years appoint 50–150 mg a day, the supported dose — 25–50 mg a day. Duration of treatment of a thyrotoxicosis varies over a wide range and 1,5–2 years can proceed. In the course of training of the patient for radiation exposure or an operative measure the dosage and duration of reception of Propitsil is defined individually.


Acute intoxication at treatment by drug was not observed, however, administration of drug in the doses exceeding therapeutic throughout the long period can lead to development of a craw and a hypothyroidism with inherent symptomatology.


At treatment by drug according to the scheme "block and substitute" together with thyroxine, Propitsil's dosage needs to be increased. At the previous or concomitant use of iodinated HP or radiopaque substances the thyreostatic effect of Propitsil decreases.

Terms of sale

According to the recipe.

Storage conditions

At a temperature not above 25 °C.

Period of validity

60 months.

Propitsil at pregnancy

Treatment by Propitsil during pregnancy has to be carried out under strict supervision of the specialist (the indicator of thyrotropin has to be lower than norm, indicators of hormones of a thyroid gland — at the upper bound of norm). For the purpose of prevention of an abortion and development in a fruit of a hypothyroidism and a craw, Propitsil's dosage has to be the lowest. At development of a diffusion toxic craw during pregnancy, Propitsil is used as monotherapy drug. B the lactation period Propitsil belongs to choice drugs. The subsequent supervision over the child for the purpose of early identification of cases of a hypothyroidism is necessary.

Propitsil's analogs

There are no structural analogs. Tiamazol-Filofarm, Potassium perchlorate, Tirozol, Mercazolil belong to drugs with similar pharmacological action.


  • Propitsil of 50 mg No. 20 of a tablet

Drugstore of IFC

  • Propitsil tbl 50 mg No. 20, Admeda Arzneimittel/Haupt Pharma Berlingermaniya
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Section: Hormonal
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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