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As a part of this medicine active component Sulpiridum and additional components contains: potato starch, silicon dioxide colloid, monohydrate of lactose, magnesium stearate, gipromelloza of K4M, gipromelloz of K15M, talc.
The HP is issued in the form of tablets, a round flat form. Tablets of white color, on the one hand are risk. Are packed into blisters on 10 pieces, three blisters are put in a cardboard pack.
Prosulpin makes psychogogic, antipsychotic, timoleptichesky impact. Active component of drug Sulpiridum is a neuroleptic which belongs to benzamide group. Shows moderate antipsychotic activity which is combined with the timoanaleptichesky and stimulating effect.
Antipsychotic influence of medicine is connected with its dofaminblokiruyushchy influence.
In the central nervous system active agent blocks generally dofaminergichesky receptors of limbic system, at the same time influences neostriatny system slightly. Makes antipsychotic impact.
The peripheral effect of Sulpiridum is connected with oppression of presynaptic receptors. When in TsNS dopamine level increases, at the same time improvement of mood of the person is noted, respectively, at his reduction the depression develops.
If Sulpiridum is accepted in a dose by more than 600 mg a day, the antipsychotic effect is shown, at reception of doses to 600 mg a day — antidepressive effect.
On GAMK-receptors, and also on adrenergic, cholinergic, histamine, serotoninovy receptors does not exert considerable impact.
Pharmacokinetics and pharmacodynamics
After administration of drug inside the greatest concentration in plasma is reached 3-6 hours later. If the patient takes a pill of 200 mg, concentration is equal to 0,73 mg on 1 l. If the patient takes a pill of 50 mg, concentration makes 0,25 mg on 1 l.
Level of bioavailability is equal to 25-35%, contacts proteins for 40%. Concentration of active component in cerebrospinal fluid low gets to erythrocytes. Into a liver gets very quickly, slowly – into brain fabrics. Through a placenta gets.
Active agent Sulpiridum only in small degree is exposed in an organism to a metabolism. It is removed through kidneys, a small amount – through intestines. Time of semi-removal is equal to 7 hours.
Indications to use
It is appointed to patients for the purpose of monotreatment or together with other psychotropic drugs:
- schizophrenia in an acute and chronic form;
- depressions of various origin;
- acute delirious states;
- the concern and neurosis (if other methods are inefficient, are applied only by the tab. of 50 mg);
- at behavior disorders at children after 6 flyings in a severe form (mutilation, agitation, a stereotypy), use of tablets is especially actual if such state is combined with autism (only tab. of 50 mg are applied).
It is not necessary to apply Prosulpin at such states and diseases:
- if strong sensitivity to Sulpiridum or to other components of this means is noted;
- prolaktinzavisimy tumors;
- acute poisoning with sleeping pill, alcohol, narcotic analgetics;
- agressive behavior, maniacal psychosis, affective frustration;
- chest feeding;
- children's age: tablets of 200 mg – till 18 flyings, a tablet of 50 mg – till 6 flyings;
- along with antagonists of dopamine receptors, sultopridy.
As as a part of medicine there is a lactose, people cannot accept Sulpiridum with inborn deficit of lactase, glyukozo-galaktozny malabsorption by a lactose intolerance.
Carefully means is appointed to people who have a liver and renal failure, epilepsy or attacks with spasms, a malignant antipsychotic syndrome, arterial hypertension, serious illnesses of heart, Parkinson's illness. It is also carefully necessary to take medicine to elderly people, women at a dysmenorrhea.
At Prosulpin's reception such side effects can be noted:
- Central nervous system: drowsiness, sedative action, a tremor, dizziness, in rare instances — an extrapyramidal syndrome, motive excitement, a hyperkinesia hyper tone, an akathisia. Cases of display of late dyskinesia at which at the person the involuntary rhythmic movements of the person, language are shown can be noted, at the same time protivoparkinsonichesky drugs are not effective or worsen a condition of the patient.
- Endocrine system: the reversible giperprolaktinemiya at which an amenorrhea, the dysmenorrhea, a galactorrhoea can be noted, in rare instances — frigidity and impotence can develop.
- Gastrointestinal tract system: increase in activity of enzymes of a liver.
- Heart and vessels: increase or decrease in indicators of arterial pressure, tachycardia, can seldom develop lengthening of an interval of QT, orthostatic hypotension.
- Lymphatic and circulatory systems: aplastic anemia, hemolitic anemia, granulocytosis, Werlhof's disease, leukocytosis.
- Allergic manifestations: rash on skin.
- Other manifestations: strong perspiration, increase in weight.
Prosulpin, application instruction (Way and dosage)
It is necessary to take medicine orally, 1–3 times a day, irrespective of reception of food, it is necessary to wash down with a small amount of water. In the second half of day it is not recommended to drink tablets as after reception the level of activity of the person can increase.
Reception of tablets of 200 mg is shown to people with schizophrenia, psychosis, a depression. In such cases the drug dose in days makes, depending on the diagnosis, from 200 mg to 1000 mg. It is necessary to divide it into several receptions.
Reception of tablets of 50 mg is shown to people with concern and neurosises, the dose in days makes from 50 to 150 mg. For four weeks it is necessary to accept the maximum dose of medicine.
To children after 6 flyings at which heavy behavior disorders are noted appoint a day from 5 to 10 mg to 1 kg of weight.
If there is a need of treatment of elderly patients, the dose has to make a quarter or a half of a dose for adults. For people with diseases of kidneys the doctor has to establish a dosage.
There is no enough data on an overdose occasion Sulpiridum. At overdose specific symptoms are absent, but at the same time development of dyskinesia with a spastic wryneck, illegibilities of visual perception, sedative action, a language protrusion, increase of arterial pressure, nausea, dryness in a mouth, etc. is possible. At some patients parkinsonism was noted.
Partial removal of Sulpiridum happens in the course of a hemodialysis. As the specific antidote is absent, it is necessary to apply the symptomatic and supporting treatment. At the same time it is important to control cordial activity and respiratory function. If at the patient the extrapyramidal syndrome is noted, to it appoint holinoblokator of the central action.
Contraindicated at treatment by Prosulpin to apply drugs — agonists of dopamine receptors (Apomorphinum, Piribedil, Amantadin, Kabergolin, Ropinirol, Bromocriptinum, Lizurid, Entakapon, Pramipeksol, Pergolid, Hinagolid).
The mutual antagonism between neuroleptics and agonists of dopamine receptors is noted. If at the patient the extrapyramidal syndrome induced by neuroleptics is noted, agonists of dopamine receptors do not apply, is in that case shown to use anticholinergic medicines.
The concomitant use of Sulpiridum and alcohol, levodopa, the drugs causing ventricular arrhythmias, the antiarrhytmic drugs Ia of a class and the III class, number of neuroleptics (Chlorpromazinum, Thioridazine, Trifluoperazin, Levomepromazinum, Amisulprid, Tsiamemazin, Pimozidum, Tiaprid, Droperidolum, Haloperidol), and also other drugs is not recommended (Difemanil, Bepridil, Tsizaprid, Mizolastin, Erythromycin intravenously, Vincaminum intravenously, Pentamidine, Galofantrin, Moxifloxacin, Sparfloksatsin, etc.).
With care it is necessary to combine drugs which cause bradycardia with Prosulpin's reception.
Hypotensive action amplifies at drug intake which oppress the central nervous system.
At a concomitant use of Sukralfat, antiacid drugs as a part of which there is Mg2 + and/or A13+, bioavailability of Sulpiridum decreases by 20–40%.
Terms of sale
Prosulpin it is possible to buy according to the recipe.
It is possible to store Prosulpin at a temperature of 15-25 °C, to protect from access for children.
Period of validity
If at the patient in the course of treatment develops a hyperthermia of the obscure etiology, it is necessary to cancel at once drug as this symptom can be a sign of a malignant antipsychotic syndrome which develops at reception of neuroleptics. Symptoms of vegetative dysfunction (strong sweating and labile the ABP) can be the guarding signs, these signs can precede development of a hyperthermia.
Before an initiation of treatment neuroleptics the patient of an ECG needs to carry out. The patient with Parkinson's illness appoint only in exceptional cases. In the course of treatment it is necessary to control a condition of patients with epilepsy.
It is impossible to drive vehicles and to work with dangerous mechanisms during treatment by this drug.
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