Протопик Drug photo

The description is actual on 08.11.2014

  • Latin name: Protopic
  • ATH code: D11AH01
  • Active ingredient: Takrolimus (Tacrolimus)
  • Producer: Astellas Pharma Europe B.V. (Netherlands)


Ointment Protopik (Protopic) has the following structure:

  • active ingredient – takrolimus in the form of monohydrate;
  • additional components — paraffin white soft, propilencarbonate, hard paraffin, liquid paraffin, white beeswax.

Release form

Medicine is on sale in plastic tubas which contain in cardboard packs.

Pharmacological action

Dermatotropic means.

Pharmacodynamics and pharmacokinetics

The protopeak is inhibitor of a kaltsinevrin. Drug contacts cytoplasmatic protein an immunoeagle owl who is a cytosolic receptor for a kaltsinevrin. At the expense of it the whole complex which includes takrolimus, calcium, kaltsinevrin, an immunoeagle owl and a calmodulin is created. It causes oppression of fosfatazny activity of a kaltsinevrin that interferes with dephosphorylation and a translocation of a nuclear factor of the activated T-cells which is necessary for the purpose of initiation of a transcription of the genes coding products of the cytokines important for the T-cellular immune response.

Active agent of ointment also oppresses a transcription of genes which code products of IL-3, IL-4, IL-5 (cytokines). Besides, it inhibits:

  • GMKSF and FNO-α participating in activation of T lymphocytes;
  • reduction of an expression of FcεRI on Langergans's cells (leads to decrease in their activity);
  • release of mediators of an inflammation from mast cells, eosinophils and basophiles.

This means does not provoke an atrophy of integuments.

Absorption in a system blood stream at external topical administration is minimum. System absorption depends on the area of defeat. It is reduced as dermatitis symptoms disappear.

Active agent of Protopik does not biotransformirutsya in integuments. At penetration into a system blood stream it is split in a liver.

At long topical administration of drug time of semi-removal makes 65 hours at children and 75 hours at adult patients.

Indications to use

Medicine is used for therapy of atopic dermatitis if other means for external use were not effective or patients have to them contraindications. Sometimes cream is appointed if treatment of vitiligo is necessary.


This means cannot be applied at:

  • considerable disturbances of an epidermal barrier;
  • feeding by a breast;
  • pregnancies;
  • children's age till two years;
  • children's age till 16 flyings (cream of 0,1%);
  • hypersensitivity to medicine components.

With care drug is appointed to people with a dekompensirovanny liver failure, and also extensive defeats of integuments.

Side effects

As a rule, at Protopik's use symptoms of irritation of integuments on site of use can appear as side reactions. Usually they are characterized by moderate degree of manifestation and pass in a week after the beginning of therapy.

Besides, the intolerance of alcohol and the increased probability of development of a folliculitis, herpes infection and an acne can be observed. Also the following collateral manifestations meet:

Cases of a rozatse and malignancy were in rare instances recorded.

Application instruction of Protopik (Way and dosage)

The instruction on Protopik reports that cream needs to be applied outwardly. It should be applied on the struck area of integuments, but not on mucous and under occlusive bandages.

Children of 2-16 years need to apply ointment of 0,03% 2 times/days. The maximum duration of treatment – 3 weeks. Further, if necessary the frequency of use needs to be reduced to 1 time a day. Therapy continues, all centers of defeat will not be liquidated yet.

The application instruction of ointment for adults and teenagers recommends to begin a course of treatment with use of cream of 0,1% 2 times/days before disappearance of all centers of defeat. As the illness will pass, it is possible to reduce the frequency of use or to pass 0,03% to cream. If displays of a disease return, therapy by ointment of 0,1% needs to be resumed twice a day. When the clinical picture allows, it is necessary to use drug less often or to pass 0,03% to ointment.

As a rule, improvements are noticeable already a week of treatment later. If they are absent within two weeks of therapy, it is necessary to consider a question of use of other means.

At aggravations ointment can be used is short-term or long in the form of the courses repeating with some frequency. It is necessary to grease the struck area of skin before absolute disappearance of symptoms of a disease. Usually improvement is noticeable after the first week of therapy. If in two weeks clinical displays of a disease did not decrease, it is necessary to consider option of use of other means.

For prevention of aggravations (if at the patient exacerbations of atopic dermatitis more than four times a year are observed) the maintenance therapy ointment is admissible. The scheme of use – two times a week to apply on an affected area of skin. An interval between drawing – not less than 2-3 days. The protopeak is used if before its efficiency was noticeable at the standard scheme of use.

For adults and children of 16 flyings ointment of 0,1%, for children till 16 flyings – cream of 0,03% is shown. If there were aggravation signs, it is necessary to pass to the standard scheme of use.

The maintenance therapy lasts 12 weeks, after that it is necessary to estimate clinical dynamics and to make the decision on whether it is necessary to apply this means. At children at the same time it is necessary to cancel medicine temporarily.


Overdose cases were not noted by means at external use.

If drug got inside, it is necessary to monitor the vital functions and to watch the general condition of the patient. It is not recommended to cause vomiting or to carry out a gastric lavage.


Active agent of drug does not biotransformirutsya in integuments that excludes a possibility of undesirable interactions with other drugs.

Vaccination is recommended to carry out prior to therapy by Protopik or two weeks later after its termination. In case of a live attenuirovanny vaccine it is necessary to wait after the termination of a course of use of cream till 4 weeks. If it is impossible, it is necessary to consider option of use of other vaccines.

Terms of sale

Medicine is sold according to the recipe of the specialist.

Storage conditions

It is necessary to store drug in the place unavailable to small children, at a temperature not above 25 °C.

Period of validity

Three years.

Protopik's analogs

Coincidence on the ATH code of the 4th level:

The most widespread analogs of ointment:

All analogs of Protopik have the features of use. It is possible to replace them only at appointment of the specialist.

About Protopike

About ointment Protopik it is possible to meet the most different. As a rule, those who already tried this means on themselves, report that it helped them. Nevertheless, messages that when using cream the severe itch, feeling of pain, reddening and other undesirable manifestations on skin developed very often meet.

Besides, at forums often ask, hormonal or not this drug. Patients with atopic dermatitis are afraid of side effects which can arise at long use of this means. Specialists hurry to calm them – medicine not hormonal. However, but corticosteroid hormones, it can in the negative plan affect immunity of the person.

About Protopike report that means helps on average in a week. There are, however, also negative opinions. Such About Protopike leave those for whom he was not effective. These people suffered from manifestation of side reactions on skin, but did not notice effect of ointment. Also some patients state fear on the fact that this means can cause cancer.


  • Protopeak ointment of 0,03% 10 g
  • Protopeak ointment of 0,1% 10 g
  • Protopeak ointment of 0,03% 30 g
  • Protopeak ointment of 0,1% 30 g

Drugstore of IFC

  • Protopeak ointment of 0,03% of a tube of 30 g, Astellas Irland Ko. Ltdirlandiya
  • Protopeak ointment of 0,1% of a tube of 30 g, Astellas Irland Ko. Ltdirlandiya
to show still


  • Ointment protopeak of 0.01% 10gastellas Farm Yurop B. V. Leyderdorp (Netherlands)


  • Ointment protopeak of 0.03% 10gastellas Farm Yurop B. V. Leyderdorp
  • Ointment protopeak of 0.03% 10gastellas Farm Yurop B. V. Leyderdorp
Section: Dermatological
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