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Tablets: Ambroxol a hydrochloride, loratadin, monohydrate of lactose, corn starch, povidone, microcrystallic cellulose, propylparaben, methylparaben, magnesium stearate, dioxide of colloid anhydrous, krakhmalglikolit sodium.
Suspension: Ambroxol hydrochloride, loratadin, sodium benzoate, sodium metabisulphite, edetat dinatrium, xanthane gum, silicon dioxide colloid, sukraloza, fragrance menthol.
Tablets of a rounded ploskotsilindrichesky shape of white color in the blister in cardboard packaging No. 10, 20.
Powder for suspension — in bottles of 60 and 100 ml in a cardboard pack.
Expectorant, immunomodulatory, antiinflammatory, antioxidant, antibechic.
Pharmacodynamics and pharmacokinetics
Properties of drug are defined by pharmacological effect of actively active ingredients.
Ambroxol the hydrochloride — has the expressed mucolytic and expectorant effect, to a lesser extent — antiinflammatory, antioxidant immunomodulatory and antibechic action. The mechanism of action is caused by stimulation of functions of serous cells of glands located in mucous bronchial tubes that is promoted increase in development of a mucous secret and normalization by a ratio of mucous and serous components. As a result — rheological properties of a phlegm are normalized, its viscosity and adhesive indicators, and also, hyperreactivity of muscles of bronchial tubes decreases.
Also, stimulates activity of a ciliary epithelium of bronchial tubes that improves evacuation of a phlegm prevents adhesion of small bronchial tubes, at the same time, does not cause a bronkhoobstruktion. In lungs drug increases the content of surfactant, improves function of external respiration, stimulates local immunity.
Loratadin — treats group of the selection blockers of peripheral histamine receptors of long action. Renders antiallergic effect, eliminates a spasm of unstriated muscles, reduces permeability of capillaries, sneezing, hypostasis of fabrics, dacryagogue, rhinitis, an itch mucous the sky and a nose. Stops development and facilitates manifestations of allergic reactions. Has no sedative effect.
At oral administration of Ambroxol the hydrochloride is well absorbed in a gastrointestinal tract. Gets through a placental barrier, GEB, to pulmonary fabric and gets to breast milk. Bioavailability makes 100%. High communication with proteins of a blood plasma.
Cmax after administration of drug is reached in 3 hours and remains within 10–12 hours. It Biotransformirutsya in a liver, it is removed with urine in the form of metabolites. Loratadin at intake shows antihistaminic action in 2–4 hours. Cmax is reached on average in 10 hours and remains within a day.
Indications to use
Symptomatic treatment of diseases respiratory in an acute and chronic form with the spastic or not expressed allergic component, the bronchial tubes proceeding with disturbance of secretion mucous and decrease in advance of slime.
Dyspepsia, nausea, dryness in a mouth, heartburn, vomiting, diarrhea, discomfort in a stomach, dizziness, local allergic reactions, a heart consciousness, increased fatigue, moderate tachycardia, sleeplessness, appetite increase.
Pulmolor, application instruction (Way and dosage)
Pulmolor to take a pill after food, washing down with water on 1 tablet 2 times a day or at the same time 2 tablets for two weeks once a day. Powder for suspension: with powder to add the cooled boiled water to a tag to a bottle and to shake up. To accept 5 ml after food twice a day or 1 time a day in a dose of 10 ml for two weeks.
Joint administration of drug with antibiotics at bacterial infections of lungs has advantages as Ambroxol increases concentration of antibiotics in tissues of lungs and facilitates treatment of respiratory diseases. At joint Pulmolor's reception with Cimetidinum, erythromycin and ketokonazoly in a blood plasma increases concentration of a loratadin.
Pulmolor does not strengthen effect of alcohol. Joint administration of drug with CYP 2D6 and CYP 3A4 inhibitors increases concentration of a loratadin.
Terms of sale
According to the recipe.
At a temperature up to 25 °C. To store ready suspension at a temperature of 2-8 °C of 14 days.
Period of validity
Coincidence on the ATH code of the 4th level:
With similar therapeutic action treat drugs: Gedeliks, Prospan, Mucaltinum, Salbroksol, Flyuditek, Alteyka, Bronkhipret, Gederin, Ambrobene, Bronkhosan, Bronkhofit, Bronkhoval, Ambrolitin, Altemiks, Termopsol, Brovensin and others.
Majority of reviews of drug favorable.
"… After walk on skis I somewhere it is strong to catch a cold. For the 2nd day cough, at the beginning of dry began, and then there was a phlegm and temperature increased. House means were not effective and it was necessary to go to policlinic on consultation to the doctor. The diagnosis — bronchitis, several drugs including "Pulmolor" wrote out. Spent on drink 10 days, the state was normalized".
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