Ravel SR

Равел СР Drug photo

The description is actual on 28.07.2016

  • Latin name:  Rawel SR
  • ATH code: C03BA11
  • Active ingredient: Indapamid (Indapamide)
  • Producer: LLC KRKA-RUS (Russia)

Structure

In 1 tablet of an indapamid of 1,5 mg. Tsellaktoza, gipromelloza, silicon dioxide, povidone, magnesium stearate as excipients.

Release form

The prolonged tablets in a cover of 1,5 mg.

Pharmacological action

Diuretic, hypotensive, vasodilating.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Possesses not expressed saluretichesky (removal of salts) and diuretic action. Suppresses absorption of sodium in renal tubules, it attracts allocation with urine of chlorine and sodium and diuresis amplifies. Slightly raises excretion of potassium and magnesium. Reduces a tone of muscles of arteries, reduces OPSS and in general has vasodilating effect. Anti-hypertensive action is shown in the doses which are not causing the expressed diuretic effect. Does not influence lowering of arterial pressure in high doses. After a tablet the maximum action is observed in 24 h. Reduces a hypertrophy of a left ventricle.

Pharmacokinetics

It is quickly soaked up in a gastrointestinal tract. Delay of absorption after meal is noted. The maximum concentration in plasma is defined in 12 hours. For 79% contacts proteins. An elimination half-life — 14-24 hours. After repeated reception cumulation is not noted. It is metabolized in a liver. Also 20% with a stake are brought by kidneys of 70%. At a renal failure the pharmacokinetics practically does not change.

Indications to use

Contraindications

  • co-administration of drugs which extend QT interval;
  • hypersensitivity;
  • the expressed renal failure;
  • persons till 18 flyings;
  • hypopotassemia;
  • hepatic encephalopathy.

With care it is applied at a diabetes mellitus, a renal failure and a liver, a hyperparathyreosis, a hyperuricemia, at increase in QT.

Side effects

Ravel SR, application instruction (Way and dosage)

Ravel WEDNESDAY of 1,5 mg is accepted inside, once a day, in the morning. A pill is taken without chewing, with a large amount of liquid. Increase of a dose does not attract strengthening of hypotensive effect.

Overdose

Overdose is shown by nausea, vomiting, spasms, decrease in the ABP, dizziness, block, the polyuria passing into an anury. In blood tests — a hyponatremia and a hypopotassemia. The gastric lavage, reception of sorbents is carried out. The specific antidote does not exist. In a hospital recovery of a water and electrolytic exchange is carried out.

Interaction

At reception with drugs of lithium its concentration increases and overdose symptoms appear. The probability of disturbances of a cordial rhythm ("pirouette") arises at reception with astemizoly, erythromycin, bepridiny, pentamidine, galofantriny, terfenadiny, sultopridy, quinidine, Disopyramidum, hydroquinidine, bretiliumy, Amiodaronum, sotaloly. It is promoted by the following factors: hypopotassemia, lengthening of an interval QT and bradycardia. The risk of a renal failure appears at co-administration of nonsteroid drugs and high doses of salicylates.

Considerably the risk of a hypopotassemia at reception with Amphotericinum increases In, cardiac glycosides, glucocorticosteroids, purgatives. Neuroleptics, Baclofenum, tricyclic antidepressants, APF inhibitors cause strengthening of hypotensive effect and orthostatic hypotension. Dehydration of an organism is observed at use with the contrast agents containing iodine. Reception of salts of calcium attracts increase in its concentration in blood. Use with other diuretics causes development of a hypopotassemia.

Terms of sale

It is released according to the recipe.

Storage conditions

At a temperature up to 25 °C.

Period of validity

2 years.

Analogs Ravela SR

Coincidence on the ATH code of the 4th level:

Arifon, Indap, Indapamid, Ionics, Lorvas, Pamid.

About Ravele SR

Convenience of tablets of the prolonged release is that the constant necessary level of an indapamid in blood for achievement of medical effect is provided. The slowed-down release is important for permanent anti-hypertensive effect at arterial hypertension.

However, there is not a lot of reviews of drug as at the expressed arterial hypertension it is not used as monotherapy, and appoint in a complex with hypotensive drugs of other groups. Considering that this diuretic (by the way, with an average force of action), during its reception it is necessary to include the products rich with potassium in a diet. Besides, by researches it is proved that long reception of Ravel SR together with APF inhibitor (Enap) improves a lipidic range (also the XC LPNP decrease OH).

Against reception of this drug decrease in level of glucose is also noted that is important at appointment as its sick diabetes mellitus. It is noted that at treatment by it elasticity of vessels which was estimated on the speed of pulse wave improves.

  • "… It is effective, it is convenient to accept once a day".
  • "… Ravel SR well helps mother, she has not really high pressure".

Patients did not note any side effects.

Zdravzona

  • Ravel SR 1,5mg No. 30 tabletkikrka, D.D./KRKA-RUS of Ltd company (RUSSIA)
  • Ravel SR 1,5mg No. 60 tabletkikrka, D.D./KRKA-RUS of Ltd company (RUSSIA)
  • Ravel SR 1,5mg No. 20 tabletkikrka, D.D./KRKA-RUS of Ltd company (RUSSIA)

Drugstore of IFC

  • Ravel SR tbl p/pl/o pro-longum. 1,5mg KRKA-Rusrossiya No. 60, KRKA/
  • Ravel SR tbl p/pl/o pro-longum. 1,5mg KRKA-Rusrossiya No. 20, KRKA/
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BIOSPHERE

  • Ravel WEDNESDAY of 1,5 mg No. 30 of the tab. pro-longum.
  • Ravel WEDNESDAY of 1,5 mg No. 60 of the tab. pro-longum.
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Section: Diuretic Cardiovascular
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Ravel WEDNESDAY surely consult with the attending physician.