Refortan

Рефортан Drug photo

The description is actual on 18.08.2015

  • Latin name: Refortan®
  • ATH code: B05AA07
  • Active ingredient: Gidroksietilkrakhmal
  • Producer: Berlin-Chemie (Germany)

Structure

In 1 l of hydroxyethylstarch of 60 g or 100 g.

Sodium chloride and water for injections — as excipients.

Release form

Solution for infusions of 6% and 10% in glass bottles on 250 and 500 ml.

Pharmacological action

Plasma substituting.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Plasma substituting drug which is 6% or 10% isotonic solution of hydroxyethylated starch. Due to the ability to connect water increases OTsK and its plasma substituting action remains 5-6 h. The hemodynamics is as a result recovered, microcirculation improves, viscosity of blood decreases, aggregation of thrombocytes and erythrocytes decreases. Has good tolerance, does not possess immunotoxic action, does not make toxic impact on bodies of RES.

Pharmacokinetics

The insignificant amount of hydroxyethylstarch collects in RES and is split by amylase. During a day of 70% of a dose it is removed with urine and with bile. Sodium chloride is removed also with urine and with then. T1/2 of drug of 4,94 h.

Indications to use

  • hypovolemic states at surgical interventions, wounds, burns, infectious diseases, intoxications which demand compensation of OTsK;
  • shock is septic, burn, traumatic;
  • cultivation of blood (hemodilution);
  • hemodilution for the purpose of reduction of volume of infusion of donor blood at operative measures.

Contraindications

  • hypersensitivity to hydroxyethylstarch;
  • overhydratation and hypervolemia;
  • intracranial and arterial hypertension;
  • hypopotassemia;
  • hyperchloremia;
  • hypernatremia;
  • thrombocytopenia and coagulopathy;
  • hypofibrinogenemia;
  • heart failure in a decompensation stage;
  • acute renal failure with existence of an anury;
  • fluid lungs;
  • age till 10 flyings;
  • pregnancy (I trimester).

Side effects

  • vomiting, grippopodobny symptoms, slight increase of temperature;
  • increase in sialadens is possible;
  • hypostases of the lower extremities;
  • skin itch (at long daily introduction);
  • pains in lumbar area;
  • increase of amylase in serum;
  • symptoms of the raised bleeding (at introduction of large volume);
  • very seldom — shock, an apnoea.

Refortan, application instruction (Way idozirovka)

Refortan of GEK 6%i 10%vvodyat in/in kapelno. A daily dose depend on a hematocrit and the amount of blood loss. Duration of therapy depends on expressiveness of a hypovolemia.

Use for compensation of OTsK — a dose of 250-1000 ml/days. In rare instances the dose increases about 20 ml by weight kg a day that is the maximum daily dose of drug. If there is no emergency situation of 500 ml of solution is entered within 60 min. and more.

Use for the purpose of hemodilution — on 500 ml several days in a row, total quantity of the administered drug of 5 l. According to indications the dose can be exceeded and distributed for 4 weeks of treatment.

Overdose

It is shown by disturbances of a hemodynamics which are connected with introduction of large volume of liquid and disturbance of coagulability of blood. Treatment consists in the immediate termination of infusion and use of diuretics.

Interaction

At joint appointment with aminoglycosides nephrotoxic action is exponentiated.

It is not recommended to mix with other infusion solutions in a type of possible pharmaceutical incompatibility.

Terms of sale

According to the recipe.

Storage conditions

It is not higher than 25 Pages.

Period of validity

5 years.

Analogs

Coincidence on the ATH code of the 4th level:

Venofundin, Volyuven, Infukol, Stabizol, Volemkor, Volekam.

About Refortana

From group of colloid plasma substitutes hydroxyethylstarch solutions — Refortan, Stabizol, Infukol who have high volemichesky effect, a big elimination half-life and insignificant side reactions are widely used recently. Solutions of hydroxyethylstarch are artificial colloids. Refortan's solution does not release a histamine therefore allergic reactions are rare. Nevertheless, appointment it is carried out after a strict assessment of indications, a ratio of risk and advantage.

These solutions cannot be used as simple infusion solutions but only for recovery of a hemodynamics in case of a hypovolemia.  Colloidal solutions are contraindicated to patients with the expressed heart failure or a craniocereberal injury.

Often responses of pregnant women meet a gestosis heavy and moderately severe which as a part of complex therapy appointed this drug. As a result of treatment the hypovolemia, intersticial hypostasis and load of heart disappeared.

This drug at treatment of obstetric bleedings is irreplaceable and at operative measures what responses of patients also testify to. Most often drug was transferred well, and reactions in the form of face reddening and a neck, the small tortoiseshell, lowering of arterial pressure were only in certain cases noted.

Zdravzona

  • Refortan of GEK of 6% solution for infusions of 500 ml No. 1 of a flakonberlin-Hema of AG
  • Refortan of GEK of 6% solution for infusions of 250 ml No. 1 of a flakonberlin-Hema of AG
  • Refortan of GEK of 10% solution for infusions of 500 ml No. 1 of a flakonberlin-Hema of AG
  • Refortan of GEK of 6% solution for infusions of 250 ml No. 10 of a flakonyberlin-Hema of AG
  • Refortan of GEK of 10% solution for infusions of 500 ml No. 10 of a flakonyberlin-Hema of AG
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Apteka24

  • Refortanberlin-Chemie/Menarini Group (Germany)
  • Refortan of N of GEK solution for infusions of 6% of a 250mlberlin-Hema (Germany)
  • Refortan of N of GEK solution for infusions of 6% 500 ml No. of a 10berlin-Hema (Germany)
  • Refortan of N of GEK solution for infusions of 6% of a 500mlberlin-Hema (Germany)
  • Refortan of N gekberlin-Chemie/Menarini Group (Germany)

Paniapteka

  • Refortan GEK solution for inf. 6% of a 500mlberlin-Hema
  • Refortan GEK solution for inf. 6% of a 500mlberlin-Hema
  • Refortan GEK solution for inf. 6% of a 500mlberlin-Hema
  • Refortan GEK solution for inf. 6% of a 500mlberlin-Hema
  • Refortan GEK solution for inf. 6% of a 500mlberlin-Hema

BIOSPHERE

  • Refortan of 6% 250 ml solution for инф.Berlin-Chemie (Germany)
  • Refortan of 6% 500 ml solution for инф.Berlin-Chemie (Germany)
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Section: Others
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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