Regeyn

Регейн Drug photo

The description is actual on 15.12.2015

  • Latin name: Regaine
  • ATH code: D11AX01
  • Active ingredient: Minoksidil (Minoxidil)
  • Producer: Aerosol-Service AG (Switzerland), Pharmacia & Upjohn Company (USA)

Structure

1 ml of solution can include 20 mg or 50 mg of a minoksidil.

In addition: alcohol (ethanol), the purified water, propylene glycol.

Release form

Regeyn is issued in the form of outside (local) solution on 60 ml in a bottle, with additional nozzles for the dosed drawing (a nozzle for rubbing in, a spray, the extended nozzle for spraying).

Pharmacological action

Stimulating and activating growth of hair.

Pharmacodynamics and pharmacokinetics

Solution Regeyn is the medicine used for treatment of a poredeniye of indumentum of the head (baldness, an alopecia). The main action of a minoksidil directionally on stimulation and activation of growth of hair at the patients suffering from an androgenic alopecia.

At outside use of drug signs of growth of hair were observed after at least 4 months of its use. The beginning of growth of indumentum of the head and degree of its expressiveness are rather variable and depend on the personal response of each patient to the carried-out treatment. Solution Regeyn of 5% exerts more significant impact on growth of hair, than 2% solution of this drug that was proved on observed addition at patients of number of vellus hair.

At cancellation of the carried-out treatment by drug Regeyn emergence of new hair is slowed down to a full stop of process and for 3-4 months gives head indumentum to the level observed prior to the beginning of problems with a hair loss.

The true mechanism of influence of a minoksidil at therapy of an androgenic alopecia is still unknown.

At outside drawing on the unimpaired integuments of the head absorption of a minoksidil remains at a low level. Less than 1,5% (with variability – 0,3-4,5%) drug from its in total used dose on average come to a system blood stream. Drawing 1 ml of 5% of solution of Regeyn (50 mg of a minoksidil) leads only 0,70 mg of drug to absorption. Influence of pathologies of skin on process of absorption of a minoksidil is not investigated.

The profile of metabolic transformations of a minoksidil, at its outside drawing, till this time is thoroughly not studied. It is known that drug does not contact plasma proteins and does not get through GEB.

At the termination of use of Regeyn about 95% of the minoksidil which is in a system blood-groove are excreted for 4 days, mainly by means of glomerular filtering with urine.

Indications to use

Solution use Regeyn is shown for the purpose of therapy of an androgenetichesky alopecia, for decrease in a hair loss and recovery of normal level of indumentum at women and men.

Contraindications

Regeyn's appointment is contraindicated at:

  • observed dermatosis of pilar part of the head;
  • pregnancies;
  • disturbances of integrity of head skin;
  • feeding by a breast;
  • personal sensitivity to a minoksidil and/or the HP other ingredients;
  • aged to 18 and after 65 years.

Side effects

Side effects of local character

The negative by-effects observed in the course of conduct of clinical trials of effects of Regeyn, as a rule, were limited to forming of dermatitis of integuments of pilar part of the head. Development of more expressed displays of the dermatitis which is characterized by a peeling, reddening and an inflammation was much less often noted.

Incidentally observed an itch of integuments of the head, contact dermatitis of the allergic nature, an alopecia, a folliculitis, seborrhea and undesirable growth of hair.

When carrying out comparative clinical trial comparison of 2% and 5% of solutions of a minoksidil and placebo showed Bol frequent development of dermatological reactions in the group using 5% drug. And 5% minoksidit weight and character of negative by-effects in the groups applying 2%, were almost comparable though the frequency of forming of collateral manifestations was higher in the last group.

Side effects of system character (less widespread, than local)

Direct relationship of cause and effect between solution use Regeyn and forming of above-mentioned side reactions was traced only at dermatological manifestations.

Regeyn, application instruction

The application instruction assumes exclusively outside putting drug Regeyn on integuments of pilar part of the head. Putting solution on other regions of a body is not allowed.

The single dosage of outside solution has to correspond to 1 ml and be put twice in the 24th hour (in the morning and in the evening). Process of putting drug should be begun with the center of problem area and further around the struck zone, using for this purpose fingers of hands or the nozzles entering packaging. The single dose of Regeyn remains invariable in independence of the area of the processed skin surface. The cumulative most admissible daily dosage equals 2 ml of solution.

The patients who are applying 2% Regeyn's solution and did not gain satisfactory effect of growth of hair and also patients with need of the fastest cosmetic increase in number of indumentum, can use drug Regeyn of 5%.

The greatest efficiency of Regeyn for women was observed at his use around a median hair parting, for men – on the top.

Instructions for use solution

Regeyn's solution should be applied only on dry and pure integuments of pilar part of the head. The choice of a way of drawing is directly connected with the used nozzle for a bottle. In case of putting drug finger-tips of hands, they need to be washed up carefully right after processing of the head.

Nozzle for rubbing in

This nozzle as well as possible will be suitable for putting solution on the small squares deprived of indumentum.

For use of this nozzle it is necessary to remove previously from a bottle with solution an outside cap and the screw-on internal cover. To densely screw up a nozzle to the place of the removed internal cover. Holding vertical position of a bottle to squeeze it with calculation of filling of the upper camera of the nozzle (containing 1 m) to black line. To turn a bottle by 180 degrees and to mass a nozzle problem sites of head skin with coverage of all area of baldness, until full emptying of the upper camera. After use of solution to put on an external cap a bottle.

Spray

This nozzle best of all will be suitable for processing by solution of the big areas of head skin.

For use of this nozzle it is necessary to remove previously from a bottle with solution an outside cap and the screw-on internal cover. To densely screw up a nozzle to the place of the removed internal cover. To remove a transparent cap from a spray, thus, having released a nozzle head. To send a head to the center of problem area and to press on the spray valve. Using finger-tips of hands to distribute solution on all area of baldness. To repeat the above described operation 6 times, for the purpose of drawing the full dose drug making 1 ml. In the course of drawing an aerosol it is necessary to avoid its inhalation and hit in eyes. After use of solution to put on an external cap a bottle.

The extended nozzle for spraying

This nozzle is most of all suitable for spraying of solution for the small areas of baldness or its drawing for the skin which is under the remained indumentum.

For use of this nozzle it is necessary to remove previously from a bottle with solution an outside cap and the screw-on internal cover. To densely screw up a nozzle to the place of the removed internal cover. To remove a small head of the sprayer from a spray and to fix the extended nozzle on the spray plug. To remove a small cap from a tip of the extended nozzle. To orient a nozzle in the center of problem area and to press once a spray. Using finger-tips of hands to distribute solution on all area of baldness and to rub slightly in skin. To repeat the above described operation 6 times, for the purpose of drawing the full dose of drug making 1 ml. In the course of drawing an aerosol it is necessary to avoid its inhalation and hit in eyes. After use of solution to put on a cap a tip of the extended nozzle.

Clinical experience of use of Regeyn says that the first signs of activation of growth of hair appeared, as a rule, after its double daily use for 4 months or even more. The beginning of growth of indumentum, degree of its expressiveness and quality of hair depend on the personal answer of an organism of the patient. In isolated cases the complete recovery of initial outward of indumentum of the head within 3-4 months was noted.

Overdose

At an inadvertent proglatyvaniye of solution Regeyn the side effects of system character caused by vasodilating effect of active ingredient of drug – a minoksidil can be observed. It is necessary to remember that 5 ml of 2% of solution Regeyn include 100 mg of a minoksidil that corresponds to the maximum recommended daily dosage of drug for therapy of arterial hypertension, and 5 ml of 5% of solution include 250 mg of a minoksidil that by 2,5 times exceeds this dose. The symptomatology of oral administration of big dosages of a minoksidil can be expressed by decrease in the ABP, a delay of liquid and tachycardia.

For the purpose of elimination of an observed delay of liquid it is possible to appoint diuretics (diuretic drugs), to carry out treatment of tachycardia by beta adrenoblockers, and therapy of arterial hypotension in/in administration of solution of sodium chloride (0,9%). In this situation use of sympathomimetic means, such as Epinephrinum or Norepinephrinum is inexpedient, because of their excessive cardiostimulating influence.

Interaction

Theoretically at parallel use of solution Regeyn and peripheral vasodilating drugs strengthening of the existing orthostatic hypotension, but for this time without clinical confirmation of this interaction is possible.

In case of Regeyn's use and parallel reception of a minoksidil inside for the purpose of therapy of arterial hypertension, theoretically perhaps insignificant increase in its serumal contents though the corresponding clinical researches in this direction were not carried out.

Purpose of solution Regeyn to the patients having arterial hypertension and accepting guanetidin or his derivatives perhaps only under continuous medical supervision.

It is proved that solution enters interaction with some other outside (local) medicines. So, the combined Regeyn's use and 0,05% of the cream including betamethasone led to reduction of absorption of a minoksidil, and parallel use of outside means with ditranoly and tretinoiny, their protective functions causing in integuments of change, can become the reason of increase in absorption of a minoksidil.

Terms of sale

Drug acquisition Regeyn does not demand existence of the recipe.

Storage conditions

The greatest possible temperature of storage of solution is equal to 25 °C.

Period of validity

  • Solution of 2% – 5 years.
  • Solution of 5% – 3 years.

Special instructions

Before therapy with drug use Regeyn potential patients should appoint the general inspection with collecting and studying of the medical anamnesis. In case of a positive assessment of the general condition of the patient it is necessary to investigate integuments of the head and it will be convinced of their integrity.

Till today's time at external use of Regeyn following effects were not observed, however because of penetration of a small amount of a minoksidil into a system blood stream development of the following negative manifestations is potentially possible: a delay of salts and water, tachycardia, local and generalized hypostasis, stenocardia, a pericardis, an exudate and a tamponade of a pericardium, strengthening of the hypotension caused by reception of some hypotensive drugs.

Throughout therapy by Regeyn patients are obliged to pass periodically inspections for the purpose of identification of the possible negative collateral system phenomena of a minoksidil. In case of detection of such phenomena therapy is stopped before clarification of their reasons.

Patients with pathologies of cardiovascular system in the anamnesis, at Regeyn's use, need to be warned about aggravation potentiality at them observed diseases.

At emergence of system side effects or heavy skin reactions patients should cancel drug and to see a doctor.

Safety and efficiency of use of drug Regeyn for therapy of persons to 18 and after 65 years, and also for treatment of patients with a dermatosis and disturbances of integuments of the head, is unknown.

The alcohol which is a part of solution, in case of its hit on mucous an eye, can become the reason of their irritation and an inflammation. In such situation it is necessary to wash out immediately eyes in large volume of cold water.

At oral administration of solution there is a high probability of forming of serious negative manifestations, generally from cardiovascular system (including tachycardia, a liquid delay, falling of the ABP). In this regard storage of drug demands the place unavailable to children.

Analogs

Regeyn's analogs on active ingredient and the main action are provided by drugs:

Zdravzona

  • Regeyn of 5% an aerosol for external use of 60 ml No. 3 bottles
  • Regeyn of 5% an aerosol for external use of 60 ml No. 1 a bottle

Drugstore of IFC

  • Regeyn aerosol naruzhn. 5% fl 60 ml No. 3, Aerozol-Service of AG of Snshveytsariya
  • Regeyn aerosol naruzhn. 5% fl 60 ml, Aerozol-Service of AG of Snshveytsariya
to show still
Section: Dermatological
in more detail

Education: Graduated from the Vinnytsia national medical university of N. I. Pirogov, pharmaceutical faculty, the higher pharmaceutical education – the specialty "Pharmacist".

Experience: Work in Koneks and Bios-Media pharmacy chains as "Druggist". Work as "Pharmacist" in Avicenna pharmacy chain of the city of Vinnytsia.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Regeyn surely consult with the attending physician.