Remantadinum

Ремантадин Drug photo

The description is actual on 25.04.2016

  • Latin name: Remantadin
  • ATH code: J05AC02
  • Active ingredient: Rimantadinum (Rimantadine)
  • Producer: Olaynfarm (Latvia), LLC Rozfarm (Russia), Irbitsky HFZ of joint stock company (Russia), OFP Obolensky FP of closed joint stock company (Russia), Tatkhimfarmpreparata of joint stock company (Russia), Moscow endocrine plant (Russia)

Structure

Structure of 1 tablet: Rimantadinum of 50 mg. Lactoses monohydrate, calcium stearate, talc, potato starch as excipients.

Release form

  • Capsules of 100 mg.
  • Tablets of 50 mg.

Pharmacological action

Antiviral.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Remantadinum, from what these tablets? This antiviral means which main mechanism — the inhibition of an early stage of a reproduction of a virus after its penetration into a cell, blocks transfer of genetic material of a virus to cell cytoplasm.

Influences an influenza virus of A and a virus of a tick-borne encephalitis (arbovirus). It is effective at reception in an initial stage of an infection (6-7 hours) that reduces incidence of flu and expressiveness of symptoms.

Pharmacokinetics

Slowly, but it is completely absorbed in a gastrointestinal tract. For 40% contacts blood proteins. Concentration of active agent in a nasal secret is higher, than plasma, for 50%. The metabolism occurs in a liver. An elimination half-life — 24-30 h. It is removed by kidneys. At patients with a renal failure collects in toxic concentration in the absence of dose adjustment.

Indications to use of Remantadinum

  • treatment of flu at early stages;
  • prevention of flu at epidemics;
  • prevention of the encephalitis caused by mites.

Contraindications

  • diseases of kidneys;
  • liver diseases;
  • thyrotoxicosis;
  • age till 7 flyings;
  • pregnancy;

With care it is appointed at arterial hypertension, atherosclerosis, epilepsy. At elderly people with the raised ABP the risk of a hemorrhagic stroke increases. At epilepsy in the anamnesis development of an epileptic seizure is possible.

Side effects

  • pains in a stomach, anorexia, swelling, dryness in a mouth, nausea;
  • headache, nervousness, sleeplessness, uneasiness, decrease in concentration of attention, excitability, drowsiness;
  • allergic reactions.

Application instruction of Remantadinum (Way and dosage)

Tablets Remantadinum, application instruction

Pill is taken inside, after food. For treatment of flu accept according to the scheme: the 1st days — on 100 mg three times, in the 2nd 3rd days — on 100 mg twice, 100 mg for the 4th day. For the purpose of prevention — on 50 mg a day from 10 to 15 days.

How to accept drug at a sting of a tick? Within the first 72 hours 2 times a day accept 100 mg.

Application instruction STI Remantadinum

For treatment of flu accept according to the scheme: the 1st days — on 100 mg three times, in the 2nd 3rd days — on 100 mg twice, for the 4th day — 100 mg of 1 times. For the purpose of prevention — on 50 mg a day from 10 to 15 days. Remantadinum Aktitab has the same indications and is applied in the same dose mode.

To children since 1 appoint Remantadinum in syrup. Syrup for children is issued under the name Orvir and Algir. The way of a dosage will be provided below.

Overdose

Overdose is shown by nausea, emergence of taste of metal in a mouth, desires on vomiting. It is characteristic psychodelic trip, followed by fear, panic, nonsense, hallucinations, intensive thought process. Intravenous administration of physostigmine in 1-2 mg (adult) and 0,5 mg to children is appointed.

Interaction

Adsorbents and the enveloping drugs reduce absorption of active ingredient.

The means acidifying urine reduce efficiency of Rimantadinum, and alkalinizing urine increase efficiency. The clearance of Rimantadinum decreases at reception of Cimetidinum.

Rimantadinum reduces effect of antiepileptic drugs.

The maximum concentration of active agent in blood is reduced by a concomitant use of paracetamol and acetylsalicylic acid.

Terms of sale

Without recipe.

Storage conditions

Temperature of storage is up to 25 °C.

Period of validity

5 years.

Remantadinum for children

The instruction on Remantadinum for children: tablets — 50 mg twice, since 10 — on 50 mg three times a day are intended to children of 7-10 years. In hard cases it is possible to give to children of 3-7 years, but in a dose of 1,5 mg/kg / in 2 receptions.

Algir (Rimantadinum + the matrix carrier alginate) children can apply syrup since 1. Sodium alginate has the adsorbing and disintoxication effect that increases anti-toxic activity of drug. Allows to reduce its dosage and to reduce risk of undesirable reactions longer time of circulation of Algirem in blood. The teaspoon of syrup contains 10 mg of Rimantadinum, accept it after food, according to the scheme.

From 1 to 3 years: on 2 h l. syrup three times a day in 1 day; on 2 h l. twice a day 2 and 3 days; 4 day – 2 h l. syrup of 1 times.

From 3 to 7 years: on 3 h l. three times a day in 1 day, on 3 h l. twice a day 2 and 3 days; 4 day – 3 h l. 1 time.
It is effective in case of inclusion in the first two days from the beginning of a disease. It is well combined with Viferon (ointment, gel, rectal suppositories).

Antiviral drugs of other groups: Tamiflu children can appoint more senior than one year — 2 mg/kg 2 times, and Arbidol is allowed for use for children since 3.

Analogs

Coincidence on the ATH code of the 4th level:

The analogs having one active ingredient and similar antiviral action: Remantadinum Sti, Olvir, Remantidin Aktitab, Polir, Algir, Arbidol, Kagotsel, Tamiflu.

Zdravzona

  • Remantadinum of 50 mg No. 20 tabletkiolainfarm
  • Remantadinum of 50 mg No. 20 tablet/biochemist/biochemist of joint stock company
  • Remantadinum of 100 mg No. 10 kapsulyolainfarm

Drugstore of IFC

  • Remantadinum tbl 50 mg No. 20, OlainFarm/of Kanonfarm (г.Москва) Russia
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Apteka24

  • Remantadinum of a tablet 50 of mg No. 20 Red Star (Ukraine, Kharkiv)

Paniapteka

  • Remantadinum of the tab. of 50 mg No. 20

BIOSPHERE

  • Remantadinum of 50 mg No. 20 of the tab. Olaynfarm (Latvia)
  • Remantadinum of 100 mg No. 10 kaps. Olaynfarm (Latvia)
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Section: Antiviral
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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