Renipril

Рениприл Drug photo

The description is actual on 28.10.2015

  • Latin name: Renipril
  • ATH code: C09AA02
  • Active ingredient: Enalapril (Enalapril)
  • Producer: JSC AI Xi HAN Leksredstva (Russia)

Structure

Enalapril maleate, milk sugar, potato starch, polyvinylpirrolidone, calcium stearate.

Release form

Tablets of a ploskotsilindrichesky form of white color in a blister strip packaging in cardboard packs No. 20.

Pharmacological action

Anti-hypertensive, diuretic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

APF inhibitor, possesses anti-hypertensive action. The mechanism of effect of drug is caused by oppression of activity of APF that leads to decrease in formation of the angiotensin II narrowing blood vessels and the activation of production of prostacyclin and kinin rendering vasodilating effect. Except decrease in the ABP, Renipril reduces load of an ischemic myocardium, lowers resistance of walls of vessels of kidneys, improves function of breath and blood circulation in a small circle, strengthens a renal and coronary blood stream, reduces aggregation of thrombocytes. Drug has poorly expressed diuretic effect which is caused by insignificant suppression of synthesis of Aldosteronum.

Time of achievement of hypotensive effect at reception orally makes one hour, the maximum effect is reached in 4-6 h and lasts about one days. Administration of drug within several weeks is necessary for most of patients for achievement of the ABP required level, and in HSN cases the lasting clinical effect is reached at administration of drug for half a year.

Pharmacokinetics

Absorption of drug at oral administration makes 60%. The food does not influence the speed of absorption. Renipril is metabolized in a liver with formation of a metabolite of enalaprilat. Drug poorly gets through a placental barrier, GEB, is slightly emitted with breast milk. Linkng with blood proteins makes about 50-60%. It is removed generally by kidneys (to 60%) and through intestines.

Indications to use

Arterial hypertension of various genesis, stage HSN I-III; prevention of ischemic states at patients with LZh dysfunction.

Contraindications

Hypersensitivity to drug and to streptocides, diseases of a liver and kidneys with the expressed dysfunctions, transplantations of a kidney in the anamnesis, primary hyper aldosteronism, pregnancy and a lactation, children's age.

Side effects

The expressed decrease in the ABP, dispepsichesky frustration, loss of appetite, dizziness, headache, fast fatigue, orthostatic hypotension, dry cough, enanthesis, dryness in a mouth, hepatitis, intestinal impassability, pancreatitis, jaundice, local allergic reactions, a photosensitization, arthritis, vision disorders and hearing, lowering of a libido, impotence.

Renipril, application instruction

Renipril accept inside both as drug for a monotepapiya, and in combinations with various anti-hypertensive HP.

Drug is accepted without binding to meal time. The dose is selected taking into account disease severity. The maximum daily dose of Renipril – 80 mg. At moderate arterial hypertension drug appoint 10 mg/days in a dose. At heart failure begin treatment with a dose of 2.5 mg, then gradually increase it to 10-20 mg for 1-2 receptions a day. Duration of therapy depends on its efficiency.

In cases of sharp decrease in the ABP the dose is gradually reduced. In the presence at the patient of diseases of kidneys it is necessary to reduce or increase a single dose intervals.

Overdose

The most frequent symptoms of overdose are: the expressed arterial hypotension accompanied with disturbances of a cordial rhythm, the increased diuresis, paresis, a renal failure, opacification of consciousness, shifts of acid-base balance, reduction of amount of electrolytes in blood serum.

As first aid it is necessary to wash out a stomach, to accept laxative and absorbent carbon. At development of arterial hypotension introduction of 0.9% of solution of sodium of chloride is shown.

Interaction

Anti-hypertensive effect of drug amplifies at reception at the same time of other anti-hypertensive HP, fenotiazin, tricyclic antidepressants, ethanol.

The concomitant use of Renipril with streptocides or derivatives of a sulfonilmochevina can be the cause of allergic reactions. Renipril reduces efficiency of the HP containing theophylline. Renipril's action is extended at a concomitant use of Cimetidinum. At co-administration with analgetics antipyretics Renipril's efficiency decreases.

Terms of sale

According to the recipe.

Storage conditions

At a temperature not above 25 °C.

Period of validity

3 years.

Renipril's analogs

Apo-Enalapril, Vazolapril, Berlipril, Vazopren, Kalpiren, Vero-Enalapril, Korandil, Lerin, Miopril, Invoril, Normapress, Minipril, Renitek, Olivine, Enazil, Ednit, Enalapril, Enaprin, Enarenal, Enafarm, Enpril, Envipril, Envas and other drugs.

About Reniprile

According to patients, drug possesses high performance. Some patients write the following: "…. I drink Renipril nearly two years. Pressure was stabilized, health good". However, many patients, except decrease in the ABP complain of emergence of dry cough.

Zdravzona

  • Renipril GT No. 20 of a tabletkifarmstandart-Leksredstvo of joint stock company
  • Renipril of 20 mg No. 20 of a tabletkifarmstandart-Leksredstvo of joint stock company
  • Renipril of 10 mg No. 20 of a tabletkifarmstandart-Leksredstvo of joint stock company

Drugstore of IFC

  • Renipril GT tbl 10 mg No. 20, Pharmstandard-Leksredstva of joint stock company (Kursk) Russia
  • Renipril tbl 10 mg No. 20 ***, Pharmstandard-Leksredstva of joint stock company (Kursk) Russia
  • Renipril tbl 20 mg No. 20, Pharmstandard-Leksredstva of joint stock company (Kursk) Russia
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Section: Cardiological Cardiovascular
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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