Rheopyrinum

Реопирин Drug photo

The description is actual on 30.06.2016

  • Latin name: Rheopyrin
  • ATH code: N02BB53
  • Active ingredient: Aminophenazonum + sodium Phenylbutazone (Aminophenazone + Phenylbutazone)
  • Producer: Gedeon Richter (Hungary)

Structure

Tablets, coated — Aminophenazonum, phenylbutazone, acid silicon, a karmelloza, titanium dioxide, eudragit, povidone, magnesium stearate, starch, talc, gelatin, sucrose.

Solution for injectionsphenylbutazone, Aminophenazonum, water sterile.

Release form

  • Solution for injections — in dark glass ampoules on 5 ml in a cardboard box No. 5.
  • Tablets — in planimetric packaging on 10 pieces in a box No. 20.

Pharmacological action

Antiinflammatory, analgeziruyushchy, febrifugal.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Drug slows down biosynthesis of prostaglandins, inactivates cyclooxygenase, interferes with synthesis of free radicals and endoperoxides, process of peroxide oxidation of fats oppresses, reduces perception of pain and slows down transfer of a painful impulse.

Pharmacokinetics

It is quickly soaked up from a gastrointestinal tract. Strong communication with blood proteins is noted. It is allocated mainly with kidneys and partially through intestines. The elimination half-life on average proceeds 78 hours.

Indications to use

  • arthritises of noninfectious genesis of various etiology;
  • neuritis, neuralgia, polyneuritis;
  • the diseases of a backbone and extraarticular fabrics proceeding with the expressed pain syndrome and an inflammation;
  • lumbago;
  • pericardis, polyserositis;
  • adnexitis;
  • iritis, retinitis, iridocyclitis;
  • parametritis.

Contraindications

High sensitivity to drug, a chronic cardiomyopathy, disturbances of a cordial rhythm, a disease of kidneys and a liver, diseases of bodies of a hemopoiesis, heart diseases.

Side effects

  • nausea, vomiting, increase of a chair, pain in a stomach, gastrointestinal tract cankers;
  • tachycardia, drowsiness, dizziness, delay of sodium (salt) and water in an organism, an itch and rash on skin, the small tortoiseshell;
  • anemia, leukopenia, agranulocytosis;
  • morbidity or abscess in the place of an injection.

Application instruction of Rheopyrinum (Way and dosage)

To take the pill Rheopyrinum inside, the adult in a daily dose of 4-6 tablets in 3 receptions. Children are 7–14 years old on 0,5–1 tablet 3 times a day.

Rheopyrinum pricks, application instruction: injections of Rheopyrinum should be done slowly (1–2 minutes) in oil deeply in a gluteus. At rheumatic diseases to enter contents of 1 ampoule daily or, if necessary, every other day. At gynecologic diseases to enter one ampoule of solution of Rheopyrinum in 4–5 days before stopping of pain and fever. To children of 7-14 years to enter 0,5–1 ml 3 times a day daily or in a day.

Overdose

In an initial stage overdose is shown by nausea, vomiting, sometimes with blood impurity, psychosis and hallucinations, in hard cases, disturbance of an electrolytic exchange and development of a coma. In 2–7 days jaundice, disturbances of an ECG, a liver failure, hemopoiesis disturbances develops.

Interaction

Rheopyrinum strengthens effect of barbiturates, gipoglikemiziruyushchy means, streptocides, anticoagulants, and weakens Difenin's action, Griseofulvin, Imipraminum, cephalosporins.

Terms of sale

According to the recipe.

Storage conditions

In the dry place at 15-25 °C.

Period of validity

3 years.

Pregnancy and lactation

At pregnancy, in connection with potential danger of aberation chromosomes in lymphocytes drug is appointed according to testimonies of the attending physician. Safety of drug in the period of a lactation is not defined.

To children

Rheopyrinum is appointed to children only under supervision of the doctor and on condition of hospitalization in a hospital at a constant control of functions of a liver, a condition of peripheral blood and urine.

Analogs of Rheopyrinum on active ingredient – Pyrabutolum.

About Rheopyrinum

About Rheopyrinum among doctors positive. Rheopyrinum possesses good tolerance at introduction within 3 days in a dose of 5 ml, the expressed antiinflammatory, febrifugal and analgetic effect that allows to use it for stopping of various profile expressed painful, inflammatory and feverish syndromes in practice of doctors. Also, Rheopyrinum can be used as choice drug for short-term appointment for the purpose of stopping of processes of an acute inflammation.

Rheopyrinum price where to buy

Rheopyrinum price in ampoules of 5 ml No. 5 varies within 245 — 282 rubles for packaging. In tablets No. 20 — on average for 230 rubles. It is possible to buy Rheopyrinum in Moscow in the majority of drugstores of Moscow according to the pre-order.

Section: Anesthetics
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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