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Cream of Retinas And consists of 0,05% cream and a tretinoin.
Means in an aluminum tuba of 30 g is issued, the tuba is in a cardboard box.
Drug renders keratolytic, antiseborrheal, antineoplastic, komedonolitichesky and local antiinflammatory action.
Pharmacodynamics and pharmacokinetics
Retinas And is retinoid, on structure similar to vitamin A. At use inside suppresses growth and differentiation of the changed blood cells, including miyeloleykozny cells. External use allows to strengthen a polifertation of cells in a papillary skin layer, to reduce adhesion of those cells which take part in formation of eels.
Processing of open eels brings to I level skin without inflammatory processes. The closed eels when processing by drug of Retinas And become open or papules which after removal of a keratinaceous stopper begin to live without hems. Also cream reduces risk of formation of new eels.
Tretinoin, being a natural metabolite of Retinolum, is soaked up from a gastrointestinal tract. Its concentration in plasma in 7-12 hours returns to initial endogenous level. High level of linkng with proteins of plasma, does not kumulirut. With urine of a tretinoin about 60%, the rest – with a stake are brought.
Indications to use
Intake is appointed at an acute promiyelotsitarny leukosis.
It is inside contraindicated to use drug at a lactation, pregnancy, sensitivity to a tretinoin, a skin epithelioma in the anamnesis.
External use is forbidden in the presence of wounds, acute inflammatory skin defeats, burns.
Drug intake can cause the following effects:
- fever, pulmonary infiltrate, dispnoe, arterial hypotension, respiratory distress syndrome, pleural exudate, liver failure, asthma, hyperleukocytosis, renal failure;
- cellulitis, rash, dryness mucous, sweating, cheilitis, xerodermia, erythema, alopecia, xerophthalmia, exfoliative dermatitis, itch;
- nausea, stomatitis, diarrhea, vomiting, dryness in a mouth, an abdominal pain, a lock, a superactivity transminaz a liver;
- depression, disturbance of consciousness, vision disorder, hearing, increase of intracranial pressure, uneasiness, dizziness;
- change of weight, increase of level of cholesterol, plasma triglycerides;
- stidor breath, pharyngitises, pleural exudate, asthma, rhinedema, rattles in lungs;
- ostealgia, joints, muscles;
- increase of bleeding;
- fever, weakness, fever, drowsiness, dorsodynia, thorax.
At external use reddening, a skin peeling, puffiness, burning, a photosensitization, emergence of a crust, blisters can be shown.
The instruction on Retinas And (A way and a dosage)
Medicine is suitable both for internal, and for external use.
The dosage is appointed for each patient individually depending on such factors as indications, a disease stage, the scheme of antineoplastic therapy.
Data on overdose are not provided by drug.
Pharmacokinetically parameters can change at simultaneous use of a tretinoin with the drugs influencing CYP450 system enzymes.
The contraceptive effect of progesteron decreases because of use of a tretinoin.
Combined use with tetracyclines can lead to increase of pressure in a skull.
The hypervitaminosis can be observed at vitamin A consumption.
Terms of sale
It is necessary to wound cream in the dry cool place at a temperature of 15-25 °C.
Period of validity
To appoint reception the Retina And inside only the doctor who has experience of treatment of oncological and hematologic diseases can.
The chemotherapy in adequate a dose is appointed at strong increase in leukocytes to prevent a syndrome of retinoic acid. Dexamethasone is appointed at emergence of the first symptoms of this syndrome.
It is not necessary to allow hits of cream in a mouth, eyes, on a mucous membrane; at hit – carefully to wash out water.
During the first week of a course acne rash can amplify.
It is necessary to avoid stay on the sun during treatment. The course can be begun after decrease in level of suntan.
It is not necessary to apply tretinoin with those drugs which cause skin desquamation. Also you should not use during treatment hygienic and cosmetics which cause irritation and a xeroderma.
Coincidence on the ATH code of the 4th level:
It is possible to refer to analogs of this drug lokatsid, vesanoid and tretinoin.
Section: Antiseptic agents
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