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Semi-synthetic antibiotic. The mechanism of influence is directed to the selection suppression of activity of a RNA polymerase of microorganisms. Medicine makes bactericidal impact on extracellular and intracellular bacteria. The antibiotic is active against mycobacteria of tuberculosis, gram-positive microorganisms. Fast drug resistance develops at monotherapy. Rifabutin is issued in the form of capsules.
Rifabutin is applied at pulmonary tuberculosis. Drug is appointed at the infectious damages caused by mycobacteria. Rifabutin is not applied at chest feeding, intolerance of the main substance, at pregnancy incubation. At heavy pathology of renal or hepatic system the antibiotic is appointed with care.
Side effect, overdose:
Dysgeusia, vomiting, nausea, jaundice, increase of level of transaminases of enzymes, anemia, mialgiya, thrombocytopenia, leukopenia, mialgiya, allergic reactions, uveitis, acute anaphylaxis, bronchospasm, eosinophilia, fever. At overdose strengthening of expressiveness of the listed side effects is registered. The gastric lavage, purpose of diuretics, posindromny therapy is required.
Route of administration:
Rifabutin appoint in 1 times a day. Reception of 300 mg a day is shown to patients with an immunosuppression for prevention of infectious defeats. At a mikobakterialny not tuberculosis infection Rifabutin is applied in a combination with other drugs before half a year on 450-600 mg a day (after receiving negative crops). At the chronic course of a polyresistant pulmonary tuberculosis the antibiotic is appointed till 6 months (from the date of receipt of negative crops) on 300-450 mg a day. At again revealed pulmonary tuberculosis reception of 150-300 mg a day is shown. At moderate pathology from kidneys and a liver correction of the mode of dosing is not required.
Antibacterial therapy is required regular carrying out blood test with a leykoformula assessment, determination of level of enzymes of a liver. The risk of development of a uveitis considerably increases at a concomitant use of a klaritromitsin or at use of medicine in large numbers. At development of a uveitis Rifabutin cancel, consultation of the ophthalmologist is required. During use of a medicine coloring of biological liquids in a reddish shade is possible. Contact lenses can be also painted in orange color. At monotherapy the probability of forming of resistance of microorganisms considerably increases. It is recommended to appoint kombinirovannub therapy with other antitubercular medicines which do not belong to group of Rifamycinums. During antibacterial therapy oral contraceptives are inefficient, use of barrier contraceptives is required.
Rifabutin accelerates process of a metabolism of medicines in hepatic system. The antibiotic reduces the level of concentration of a zidovudine in blood. Development of clinically significant interactions with Pyrazinamidum, streptocide, theophylline, Ethambutolum, zaltsitabiny, flukonazoly is improbable. Klaritromitsin and flukonazol are capable to increase the level of concentration of an antibiotic in blood.
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