Rifampicin

Рифампицин Drug photo

The description is actual on 06.06.2015

  • Latin name: Rifampicin
  • ATH code: J04AB02
  • Active ingredient: Rifampicin
  • Producer: Northern star (Russia), Krasfarm (Russia), Farmsintez (Russia), Mistletoe (Russia)

Structure

One ampoule contains 150, 300, 450 or 600 mg of active ingredient rifampicin. Additional elements are: ascorbic acid, sodium sulfite

One capsule contains 150 or 300 mg of active component.

Release form

Capsules and lyophilisate for preparation of solution for infusions.

Pharmacological action

Semi-synthetic antibiotic. Has antitubercular and antibacterial effect.

Pharmacodynamics and pharmacokinetics

Low concentration of drug make bactericidal impact on chlamydias, mycobacteria of tuberculosis, a rickettsia, legionella, leprosy mycobacterium. High concentration of drug are active against gram-negative flora.

Rifampicin is antitubercular medicines of the first row. High activity is noted at influence on staphylococcus, a clostridium, gonokokk, meningokokk. Medicine influences on vnekletochno, and also intracellularly located bacteria.

The mechanism of action is based on suppression of a RNA polymerase of microorganisms. Cross stability with other antibacterial agents is not registered. At monotherapy medicine observes fast development of selection of microorganisms to an antibiotic.

Indications to Rifampicin use

Drug is used as a part of a combination therapy at all forms of tuberculosis, at a leprosy. At a multibacillar type of a leprosy the antibiotic is appointed together with dapsone.

What else there are indications to use? Medicine is appointed at a brucellosis, infectious diseases, a spotted fever.

Contraindications

Medicine is not applied at chest feeding, jaundice, intolerance of the main substance, to children of chest age, at severe forms of cardiopulmonary insufficiency, at pathology of kidneys, infectious hepatitis. At pregnancy Rifampicin is applied according to "vital" indications.

Side effects of Rifampicin

Digestive tract: pseudomembranous coloenteritis, vomiting, appetite disturbance, nausea, increase of level of enzymes of a liver, hepatitis, hyperbilirubinemia, diarrhea, erosive gastritis.

Nervous system: disorientation, decrease in visual acuity, headache, ataxy.

Urinogenital system: intersticial nephrite, nefronekroz.

Development of a hyperuricemia, myasthenia, leukopenia, allergy, exacerbation of gout, dysmenorrhea, porphyria infuktion is possible.

At irregular use of medicine development of a grippopodobny state and such side effects is possible: mialgiya, fever, fever, dizzinesses, headaches.

Application instruction of Rifampicin (Way and dosage)

Drug is accepted inside, entered intravenously kapelno.

Tablets Rifampicin, application instruction

Take for half an hour to food, on an empty stomach.

In therapy of tuberculosis this medicine needs to be combined with other antitubercular medicines (Ethambutolum, Pyrazinamidum, an isoniazid). The adult appoint 10 mg/kg of times at 24 o'clock. A day no more than 1200 mg, to children — no more than 600 mg.

Tuberculosis combination to HIV, defeat by tubercular process of a rachis with neurologic symptomatology, the disseminated tuberculosis, tubercular meningitis: 2 months apply Rifampicin with Pyrazinamidum, an isoniazid, Ethambutolum, streptomycin, the next 7 months combine an antibiotic with an isoniazid.

At detection of a mycobacterium in a phlegm, a pulmonary form of tuberculosis to the patient appoint one of three schemes of antimicrobic therapy using in a combination with other drugs.

Multibacillar types of a leprosy (boundary, lepromatous, mixed): once a month 600 mg together with dapsone once a day on 100 mg and clofazimine (300 mg once a month, 50 mg daily).

Pausibatsillyarny types of a leprosy (boundary tuberculoid, simple tuberculoid): once a month 600 mg together with mg dapsone 100 daily, the course of therapy is expected half of year.

Therapy of a brucellosis: once 900 mg on an empty stomach in the morning together with doxycycline, the course is expected 45 days.

Prevention of a spotted fever: each 12 hours of 600 mg, a course for 2 days.

Solution use

In/in adult appoint 600 mg a day, to children on 10 mg to kg of times a day. The maximum dose at intravenous administration makes 600 mg.

Overdose

It is shown by confusion of consciousness, a convulsive syndrome, a fluid lungs.

The gastric lavage, artificial diuresis, reception of enterosorbents is necessary.

Interaction

Rifampicin reduces activity of drugs of a foxglove, peroral hypoglycemic medicines, anticoagulants, contraceptives, antiarrhytmic means (tokainid, pirmenol, Disopyramidum, meksiletin, quinidine), Phenytoinum, dapsone, glucocorticosteroids, a ketokonazol, a dloramfenikol, sex hormones, benzodiazepines, a nortriptilin, hexobarbital, cyclosporine, Cimetidinum, an epalapril, BMKK, beta adrenoblockers, Azathioprinum (rifampicin is capable to accelerate a metabolism due to the caused induction of operedelenny enzymes of hepatic system).

Ketokonazol, anticholinergics, opiates, antacids reduce an indicator of bioavailability of an antibiotic.

At a concomitant use of Pyrazinamidum or an isoniazid hepatotoxic influence amplifies.

It is possible to appoint drugs PASK after 4 hours after use of rifampicin for absorption prevention.

Terms of sale

The recipe is required.

Storage conditions

In the place, dark, dry, unavailable to children, at a temperature no more than 25 degrees Celsius.

Period of validity

No more than two years.

Special instructions

Antibacterial therapy can lead to coloring of urine, lacrimal liquid, a calla, sweat, integuments and a phlegm in reddish color. Perhaps permanent coloring of contact lenses.

Intravenous injections of rifampicin are carried out under control of a blood pressure. Long therapy leads to forming of phlebitis. The medicine is applied to resistance prevention in a combination with other antibiotics, antimicrobic means.

At registration of a grippopodobny syndrome (without bronchospasm, hemolitic anemia, an asthma, a renal failure, shock, thrombocytopenia) at patients who accept a medicine according to the intermittent scheme the attending physician needs to consider a question of transition to everyday reception of an antibiotic. In this case increase of a dose happens slowly, on titration 3-4 days leave. Regular control over a condition of renal system is required, use of glucocorticosteroids is possible.

Rifampicin at pregnancy is applied only according to vital indications. Purpose of an antibiotic in the last days of incubation of pregnancy can cause bleedings in the newborn, and also puerperal bleedings at mother. In such cases purpose of vitamin K is recommended. Women during antibacterial therapy should be protected from pregnancy approach reliably.

When carrying out prevention of bacilli carriers of a meningokokk strict control over group for early detection of symptoms at development of resistance to an antibacterial medicine is required.

It is long the proceeding therapy demands regular control over a condition of hepatic system, peripheral blood.

The medicine influences indicators of level of B12 vitamin and folic acid in blood serum.

The recipe on Latin

Rp.: Rifampicini 0,3
    D. t. d. N 20 in caps. gelat.
    S.

Analogs of Rifampicin

Coincidence on the ATH code of the 4th level:

Analogs are drugs: Makoks, Rifampinum, Rifatsina, R-Qing.

Zdravzona

  • Rifampitsin-Fereyn powder for solution 150 of mg No. 10 ampulybryntsalov-A
  • Rifampicin 150 of mg No. 20 of a kapsulybelmedpreparata
  • Rifampicin 150 of mg No. 10 of a kapsulybelmedpreparata
  • Rifampicin 5 of ml No. 10 of amp.
  • Rifampicin powder for solution 150 of mg No. 10 of an ampulybelmedpreparata

Drugstore of IFC

  • Rifampicin kaps 150 mg No. 100, Belmedpreparata (Minsk) Belarus
to show still

Apteka24

  • Rifampitsinborshchagovsky HFZ (Ukraine, Kiev)

Paniapteka

  • Rifampicin kaps. 150 mg No. 20
Section: Antibiotics
in more detail

Education: Graduated from the Bashkir state medical university majoring in "Medical business". In 2011 gained the diploma and the certificate in Therapy. In 2012 received 2 certificate and the diploma in "Functional diagnosis" and "Cardiology". In 2013 completed courses on "Topical issues of otorhinolaryngology in therapy". In 2014 completed advanced training courses in "A clinical echocardiography" and courses in "Medical rehabilitation".

Experience: From 2011 to 2014 the Policlinic No. 33 Ufa worked as the therapist and the cardiologist in MBUZ. Since 2014 the Policlinic No. 33 Ufa works as the cardiologist and the doctor of functional diagnosis in MBUZ.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Rifampicin surely consult with the attending physician.