Ронколейкин Drug photo

The description is actual on 19.09.2014

  • Latin name: Roncoleukinum
  • ATH code: L03AC
  • Active ingredient: Interleykin-2 person recombinant (Interleukin-2 human recombinant)
  • Producer: LLC NPK BIOTEH (Russia)


Solution contains 100000, 2500000, 500000 and 1000000 ME human recombinant interleykina-2.

Auxiliary ingredients according to the content of active agent:

  • 1 mg / 2,5 mg / 5 mg / 10 mg — lauryl sulfate sodium;
  • 5 mg / 12 mg / 25 mg / 50 mg — Mannitolum;
  • 0,79 mg — hydroammonium carbonate;
  • 0,08 mg — a ditiotreitola;
  • to 1 ml — water for injections.

Release form

Solution for subcutaneous and intravenous injections.

One packaging contains 3 or 5 ampoules of solution on 1 ml.

Pharmacological action

Immunomodulatory action.

Pharmacodynamics and pharmacokinetics

Ronkoleykin is an immunostimulator and possesses antifungal, antineoplastic, antiviral and antibacterial activity.

Interleykin-2 actively influences process of start and further forming of an immune response, shows multiple impact on different links and components of immune system of the person.

Activates proliferation of T lymphocytes that leads to their cytotoxic action as killerny cells, the range of the lyseing effects at the same time extends to a possibility of effective counteraction to various pathogenic microorganisms and malignizirovanny cells.

Also stimulates development with immunoglobulin B-lymphocytes, increases functionality of fabric macrophages and monocytes.

Indications to use

Medicine Ronkoleykin is applied in complex therapy at patients of adult age:

  • at combined immunodeficience;
  • at a usual variable immunodeficiency;
  • at acute peritonitis;
  • at osteomyelitis;
  • at acute pancreatitis;
  • at an endometritis;
  • at sepsis;
  • at a pulmonary tuberculosis;
  • at heavy pneumonia;
  • at puerperal sepsis;
  • at the infected thermal and corrosive burns;
  • at other generalized and expressed localized infections;
  • at the locally-spread and disseminated forms of nephrocellular cancer.

At children's age, since 0 months, drug is shown:

  • at combined immunodeficience;
  • at a usual variable immunodeficiency;
  • at acute peritonitis;
  • at osteomyelitis;
  • at acute pancreatitis;
  • at heavy pneumonia;
  • at sepsis;
  • at bacterial sepsis of newborns;
  • at the other generalized and expressed localized infections.


  • hypersensitivity to Ronkoleykin's ingredients, including in the anamnesis;
  • pregnancy period;
  • the diagnosed allergy to yeast;
  • autoimmune pathologies;
  • heart failure (3rd degree);
  • metastatic damage of a brain;
  • pulmonary heart (3rd degree);
  • nephrocellular cancer in an end-stage.

With extra care it is necessary to appoint at a chronic renal and dekompensirovanny liver failure.

Side effects

In rare instances, after procedure of administration of drug Ronkoleykin observed a short-term fever and the increased body temperature. These reactions are not the indication for cancellation of introduction of Ronkoleykin, and also the termination of therapy and are stopped by simple therapeutic means.

When carrying out subcutaneous injections local reactions – reddenings, consolidations and morbidity in an injection site were noted.

Application instruction of Ronkoleykin (Way and dosage)

The instruction on Ronkoleykin recommends one-time hypodermic or intravenous (in the form of infusions) administration of drug in a dose of 0,5 mg — 1 mg with breaks from 24 hours to 3 days. The therapy course, as a rule, consists of 1-go-3-h introductions.

For intravenous injections contents of one ampoule of drug are dissolved in 400 ml of injection isotonic solution of sodium chloride. Infusion is carried out for 4-6 hours. Solution of medicine has to be colourless and transparent without any foreign inclusions.

The immunotherapy using Ronkoleykin's drug is shown after carrying out urgent, difficult surgeries which are directed to elimination of negative effects of a disease or injury, life-threatening the patient; sanitation, and also drainage of the center of an infection.

At therapy of heavy sepsis appoint from 1st to 3 courses of treatment drug Ronkoleykin. The conducted course includes 2 intravenous infusions of medicine in a dose of 0,5 mg in a day. The indication for purpose of further courses of therapy is the lymphopenia remaining during treatment.

At for the first time the diagnosed infiltrative destructive pulmonary tuberculosis appoint carrying out 3 intravenous injections in the form of infusion in a dose of 0,5 mg with a break in two days, against special polychemotherapy.

When carrying out preoperative training of the patient suffering progressing FCT (fibrous and cavernous tuberculosis) of lungs on condition of passing of specific polychemotherapy recommend carrying out 3 intravenous infusions in a dose of 1 mg, with a break of 48 hours.

In case of widespread FKT of lungs with focal dissimination of bilateral character appoint 7 intravenous infusions in a dose of 1 mg, with carrying out the first 3rd from them for the first week, with a break of 48 hours. The subsequent injections carry out in the same dose 2 times a week for 14 days. The course of an immunotherapy needs to be completed in 7-10 days prior to operation.

Ronkoleykin's use at a disease a pulmonary tuberculosis with deficit of body weight of the patient more than 30% is inexpedient.

The course of therapy of the locally-spread and disseminated forms of nephrocellular cancer is carried out in 24 hours prior to an operative measure, using single hypodermic or intravenous administration of Ronkoleykin in a dose of 0,5 mg.

When carrying out a 8-week course of immunochemotherapy recommend intravenous injection of drug for the first 4 weeks of treatment in a dose of 2,0 mg in a day. Repeated courses of therapy are conducted in 1-2 months.

To patients of children's age appoint Ronkoleykin in the form of intravenous infusions with saving schemes of treatment for adult patients and with the single doses depending on age:

  • aged from 0 months till 1st month in the dose of 0,1 mg of drug divorced in 30-50 ml of 9% of injection solution of sodium chloride;
  • aged from 1 month till 12 months in the dose of 0,125 mg divorced in 100 ml of solution;
  • aged from a year till 7 flyings in the dosage of 0,25 mg divorced in solution of 200 ml;
  • 7 years in the dosage of 0,5 mg divorced in solution of 200 ml are aged more senior;
  • 14 years in the dosage of 0,5 mg divorced in solution of 400 ml are aged more senior.

In parallel with drug Ronkoleykin for the person, the pharmacological industry lets out medicine for use in veterinary science, in particular for treatment of domestic animals.

Ronkoleykin to cats and for dogs apply to treatment of various diseases, beginning from infectious and finishing oncological.

Dosage and method of use of drug Ronkoleykin for cats, dogs and other domestic animals selects the veterinarian proceeding from data on weight, age of an animal and the diagnosed disease.


After introduction of a single dose of drug Ronkoleykin more than 7 mg were observed symptoms in the form of disturbances of a heart rhythm, fever, dermatological allergic manifestations, hypotonias.

These symptoms disappear independently after cancellation of injection introduction, if necessary appoint symptomatic therapy.


Therapy using Ronkoleykin can be carried out in combination with other medicines.

When passing by the patient of a long course of therapy with use of glucocorticosteroids Ronkoleykin's activity can decrease.

Mixing rolled into one or Ronkoleykin's syringe and other injection drugs is not allowed.

Terms of sale

According to the recipe.

Storage conditions

At a temperature of 2-8 °C (in the refrigerator).

Period of validity

24 months.

Special instructions

At Ronkoleykin's storage at a temperature from 2 to 8 °C (in the refrigerator) forming of crystals of sodium of lauryl sulfate is possible. At the room temperature crystals have to be dissolved in solution for half an hour. For acceleration of this process it is possible to incline a drug ampoule, avoiding a sharp sbaltyvaniye of solution and foaming.


Analogs of drug Ronkoleykin are presented by two drugs in the lyophilisate form for p / to and in/in introductions Betaleykin and Proleykin.


  • Ronkoleykin solution for injections of 1000000 ME 1 mg No. 3 ampulybiotekh Ltd company
  • Ronkoleykin solution for injections 250000 ME 0,25mg No. 3 ampulybiotekh Ltd company
  • Ronkoleykin solution for injections 500000 ME 0,5mg No. 3 ampulybiotekh Ltd company

Drugstore of IFC

  • Ronkoleykin solution for inf and p / to vved. 500000ME of amp No. 3, NPK of Biothat of Ooorossiya
  • Ronkoleykin solution for inf and p / to vved. 1000000ME of amp No. 3, NPK of Biothat of Ooorossiya
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Section: Immunity increase
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Education: Graduated from the Vinnytsia national medical university of N. I. Pirogov, pharmaceutical faculty, the higher pharmaceutical education – the specialty "Pharmacist".

Experience: Work in Koneks and Bios-Media pharmacy chains as "Druggist". Work as "Pharmacist" in Avicenna pharmacy chain of the city of Vinnytsia.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Ronkoleykin surely consult with the attending physician.