Rutoside

• Chemical name
• Chemical properties
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications to use
• Contraindications
• Side effects
• Rutoside, application instruction (Way and dosage)
• Overdose
• Interaction
• Terms of sale
• Special instructions
• At pregnancy and a lactation
• Analogs
• Responses

Chemical name

3-[[6-0 (6-Dezoksi-alfa-L-mannopiranozil) - beta D - glyukopiranozil] oks]-2-(3,4 dihydroxyphenyl) - 5,7 - dihydroxy - 4H-1 - petrolpyrane - 4 - it

Chemical properties

Rutoside, what is it? This chemical compound – a meletin flavonoid glycoside. It is also called by Rutinum, sophorin or meletin - 3........... Substance possesses ability to reduce permeability of capillaries, to increase elasticity of erythrocytes and to reduce coagulability of blood. The molecular mass of means = 610,5 grams on mol. Its action is similar to effect of vitamin P reception.

In food of routines it is possible to find in leaves of a fragrant rue, a tea-plant, a buckwheat, blackcurrant, blackberry, a mountain ash, currant, a black-fruited mountain ash and a citrus (especially in a peel and between segments).

Rutoside trihydrate, what is it? this component most often is In medicines in the form of trihydrate as a part of tablets or 20% of gel for external use.

Pharmacological action

Angioprotektivnoye.

Pharmacodynamics and pharmacokinetics

Rutoside reduces permeability of capillaries, strengthens walls of vessels. Under the influence of this means puffiness falls down and there passes the inflammation. Substance slows down processes of aggregation of erythrocytes and increases their elasticity.

Medicine exerts impact on veins and capillaries. During treatment of patients with chronic venous insufficiency or a lymphostasis reduction of expressiveness of painful feelings and puffiness was noted. Gel calms and cools skin.

After reception of tablets the maximum concentration of active ingredient is reached within 1-9 hours. The elimination half-life makes from 10 to 25 hours. Means in the form of metabolites or in not changed look, mainly with bile, to a lesser extent – with urine is removed.

Rutoside which is in composition of ointment or gel well gets into deep layers of skin. It is possible to define medicine in skin in 30 minutes, in hypodermic cellulose – in 2-5 hours.

Indications to use

Rutoside Trihydrate is appointed:

• at a varicosity;
• for treatment of superficial thrombophlebitises;
• to patients with chronic venous insufficiency to liquidate pain, ulcers, trophic disturbances, to remove hypostasis;
• at hemorrhoids;
• sick posttrombotichesky syndrome;
• at an azotemic, diabetic, atherosclerotic retinitis;
• for elimination of lymphatic disturbances after radiation therapy;
• at a lymphostasis;
• to kill pain and hypostasis after an injury.

Contraindications

Drug is contraindicated to reception:

• in 1 trimester of pregnancy;
• at an allergy to active ingredient.

Side effects

At reception of the tablets Rutoside there can be unpleasant feelings in a stomach, an indigestion, inflow, a headache, an allergic enanthesis (seldom).

At outside use locally the irritant action, skin rash sometimes develops (allergic).

Rutoside, application instruction (Way and dosage)

Tablets are appointed inside, during meal. The daily dosage is distributed on 2 receptions. The adult healthy person is during the day recommended to accept from 100 to 150 mg of this substance. Duration of treatment is defined by the doctor.

Gel is applied on skin by 2 times a day and accurately rub. After disappearance of symptoms (the course of treatment usually takes from 2 to 4 weeks) therapy is continued during even some time.

Overdose

There are no data on overdose by drug.

Interaction

Pharmacological effect of drug amplifies under the influence of ascorbic acid.

Terms of sale

The recipe is not necessary.

Special instructions

This drug is appointed most often as a part of complex treatment. Also positively disease is influenced by parallel reception of ascorbic acid. Reception of a digidroergokristin and esculin is shown.

At pregnancy and a lactation

Medicine is contraindicated on the first trimester of pregnancy. There are no data on safety of use of drug during feeding by a breast. It is recommended to consult with the doctor.

Drugs in which contains (Analogues)

Trade names of Rutoside of trihydrate: Venorutonum, Rutinum.

Also substance is a part of drugs Profilaktin With and Ascorutinum in a combination with ascorbic acid.

Means contains in the drugs Vicalinum, АнГриКапс a maxim, etc.

Responses

About use of means good. Medicine is rather effective, possesses the minimum quantity of side effects. The best result can be achieved at a means combination to ascorbic acid or other drugs.