Сайтотек Drug photo

The description is actual on 20.03.2015

  • Latin name: Cytotec
  • ATH code: A02BB01
  • Active ingredient: Mizoprostol (Misoprostol)
  • Producer: Pfizer Inc. (USA)


One tablet of drug Saytotek includes 200 mkg of a mizoprostol.

Additional substances: castor oil, sodium carboxymethylstarch, microcrystallic cellulose, silicon dioxide.

Release form

White ploskotsilindrichesky tablets with a notch.

10 tablets in the blister; one, two, five or three blisters in a box from a cardboard.

Pharmacological action

Antiulcerous action.

Pharmacodynamics and pharmacokinetics


Tablets Saytotek belong to anti-secretory, antiulcerous drugs and have also tsitoprotektory properties.

Mizoprostol is artificial analog of E1 Prostaglandin which possesses protective action on a mucous membrane of intestines and a stomach. Increases resistance of an internal cover of a stomach to action of negative factors: irrational food, alcohol, stresses, anti-inflammatory nonsteroid drugs; promotes a tightening of round ulcers, stops emergence of erosive and ulcer frustration.

The cytoprotective effect of drug is connected with increase in products of slime in a stomach and increase in own secretion of bicarbonate mucous a stomach. Medicine possesses also anti-secretory activity, reacting with E-type prostaglandin receptors. Exerts a direct impact on stomach cells, slows down night, basal and stimulated secretion of hydrochloric acid, reduces quantity and proteolytic activity of a gastric juice. Weakens basal products of endogenous pepsin. Strengthens a blood stream in stomach covers. Effect of drug begins half an hour later after reception and at least 3 hours proceed. The effect has the expressed dozozavisimy character. Increases force and frequency of reductions of a myometrium and muscles of intestines.


It is quickly soaked up (reception of food slows down absorption). In walls of intestines and in a liver mizoprostol it biotransformirutsya with formation pharmacological of active mizoprostolovy acid. The greatest concentration is created approximately in 12 minutes, circulates in a vascular bed in a complex with proteins (to 90%). Time of semi-removal can reach 40 minutes. Equilibrium concentration of active agent in blood is reached 2 days later, accumulation is not observed. To 80% of the accepted dose it is removed by kidneys, at disturbance of their functioning increase in an elimination half-life and increase of the maximum concentration is possible twice.

Indications to use

  • Treatment and prevention of defeats mucous a stomach and a 12-perstny gut of erosive and ulcer character caused including reception of anti-inflammatory nonsteroid drugs.
  • Medicamentous abortion (at medicamentous abortion in the majority of the countries medicine is used without official permission and without information, necessary for the patient, on safe use).


  • Cardiovascular diseases.
  • Hypersensitivity to drug components.
  • Damages of a liver and kidneys.
  • Endocrinopathies and defeats of endocrine system.
  • The diseases connected with dependence on prostaglandins.
  • Anemia.
  • Hormonedependent tumors. +
  • Lactation period.
  • Age till 18 flyings.
  • Suspicion on an extrauterine pregnancy.
  • Use of intrauterine contraceptives.
  • Pregnancy (if drug is not used for the purpose of its interruption).

Side effects

  • Frustration from digestion: abdominal pains, vomiting, diarrhea, dyspepsia, nausea, meteorism, lock.
  • Frustration from the sexual sphere: pains in the first floor of a stomach, a hypermenorrhea, a dysmenorrhea, postmenopauzny vaginal allocations of bloody character.
  • Other frustration: a headache, spasms at women in a paraclimacteric, an adynamy, fatigue, change of body weight, rash.

Application instruction (Way and dosage)

The instruction on Saytotek provides drug use only for treatment and prevention of a peptic ulcer and does not distribute the recommendation to use of means for abortion. Drug is accepted during food orally.

For treatment of the ulcers caused by use of anti-inflammatory nonsteroid drugs, the instruction on Saytotek orders to accept 800 mkg of drug twice a day within 1-2 months.

For the prevention of the ulcers caused by use of anti-inflammatory nonsteroid drugs, medicine is taken on 200 mkg by 2-4 times a day during the entire period of treatment by anti-inflammatory nonsteroid drugs.

Saytotek for abortion

Use till 63 days is made for abortion only in combination with Mifepristone, the trained staff in special medical institutions with a possibility of rendering the emergency help. In later terms drug is inefficient.


The person has no data on toxicity of a mizoprostol. Symptoms testimonial of exceeding of a dosage: drowsiness, bradycardia, spasms, tremor, abdominal pain, heartbeat, fever, arterial hypotension.


At combined use with antacids concentration of active agent in blood goes down.

At simultaneous use with magniysoderzhashchy antacids strengthening of diarrhea is not excluded.

At combined use with Diclofenac or Indometacin side effects of the last are stimulated.

Terms of sale

According to the recipe.

Storage conditions

To store in the dry place at a temperature up to 30 °C. To protect from children.

Period of validity

3 years.

Special instructions

It is necessary to appoint medicine with care the patient with coronary heart disease, arterial hypotension, frustration of cerebral circulation, diarrhea, epilepsy, koronarokardiosklerozy, a coloenteritis, hypersensitivity to prostaglandins.

At appointment patients of reproductive age need to prepost the test for pregnancy. The test has to remain negative within 2 weeks before drug use. It is authorized to begin treatment only 2 days later after the beginning of monthly. Throughout the entire period of reception it is necessary to use reliable methods of contraception. Mizoprostol increases a tone of a uterus and is capable to provoke an abortion.


Mizoprostol, Mizoprostol-GPMTs, Mirolyut.

Section: Gynecologic Gastrointestinal
in more detail

Education: Graduated from the Vitebsk state medical university majoring in "Surgery". At university headed Council of students' scientific society. Professional development in 2010 - in "Oncology" and in 2011 - in "A mammology, visual forms of oncology".

Experience: Work in an all-medical network 3 years the surgeon (The Vitebsk hospital of an emergency medical service, Lioznensky TsRB) and in combination the regional oncologist and the traumatologist. Work farm the representative within a year in the Rubicon company.

Provided 3 improvement suggestions on the subject "Optimization of an Antibioticotherapia depending on Species Composition of Microflora", 2 works took prizes in a republican competition review of student's scientific works (1 and 3 categories).
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