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Seknidazol, corn starch, calcium hydrophosphate, microcrystallic cellulose, glikolit starch sodium, povidone, magnesium erases, the purified talc, a gipromelloza, titanadioksid, the purified talc, propylene glycol.
Tablets of 1.0 g, coated in planimetric packaging from aluminum foil and a polyvinyl chloride film on 2 tablets in a cardboard pack.
Pharmacodynamics and pharmacokinetics
The antiprotozoan drug with antibacterial action relating to group of nitroimidazoles possesses bactericidal and amebitsidny action. Seknidoksos it is active especially concerning trichomonads, a dysenteric amoeba, an intestinal lyambliya.
Getting into a microorganism cell, Seknidazol interacts with DNA, destroying its spiral-shaped structure, inhibition of synthesis of nucleotides and death of a cell. Drug possesses teturamopodobny action (a sensitization to alcohol), increases sensitivity of tumors to radiation.
Drug after intake is completely and quickly soaked up in a gastrointestinal tract, breaks a blood-brain barrier and gets into breast milk. With max in blood it is reached within 4 hours. Bioavailability about 80%. Seknidoksos it is metabolized in a liver. It is removed by kidneys for 72 hours.
Indications to use
Organic lesions of TsNS, the increased individual sensitivity to drug, a blood disease, age till 12 flyings, the period of pregnancy and a lactation.
Seknidoks, application instruction (Way and dosage)
Tablets of Seknidoks is accepted before meal, washing down with water.
Doses for adults at various diseases:
Bacterial vaginosis, mecotic vaginitis and uretrita, an acute symptomatic amebiasis — once 2 tablets; asymptomatic amebiasis, including cystic and focal forms: on 2 tablets once daily within three days. At a liver amebiasis — on 1,5 tablets daily within five days. Important: at Seknidoks's reception it is impossible to take alcohol!
Doses for children are more senior than 12 years:
At an intestines amebiasis — an asymptomatic amebiasis: 30 mg/kg of weight of the child within three days; acute symptomatic amebiasis and lambliasis: once, in a dose of 30 mg/kg of weight of the child. At a liver amebiasis — a separate or single dose daily for 5 days in a dose of 30 mg/kg of weight.
Leukopenia, ataxy. Strengthening of symptomatology of collateral manifestations is also possible.
Drug at a concomitant use strengthens action of derivatives of Coumarin (indirect anticoagulants).
The concomitant use of drug with Disulfiramum can provoke paranoiac reactions (nausea, vomiting, abdominal pains, a headache).
At simultaneous use of Seknidoks with drugs of lithium increases its concentration in blood.
Seknidoks it is not recommended to apply with muscle relaxants (bromide a vekuroniya).
Terms of sale
According to the recipe.
At a temperature up to 25 °C.
Period of validity
Structural analogs of drug are: Seknizol 500, Tagera Forte.
About drug good. Most of patients note its high performance.
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