Semaks

Семакс Drug photo

The description is actual on 19.05.2016

  • Latin name: Semax
  • ATH code: N06BX
  • Active ingredient: Метионил-глутамил-гистидил-фенилаланил-пролил-глицил-пролин (Methionyl-glutamyl-histidil-phenylalanyl-prolyl-glycyl-proline)
  • Producer: PEPTOGEN the Innovation research and production center (Russia)

Structure

  • Drops of Semaks of 1% of 1 ml include 10 mg of the active ingredient of the same name. Additional components: methylparahydroxybenzoate, water.
  • Drops of Semaks of 0.1% of 1 ml include 1 mg of the active ingredient of the same name. Additional components: methylparahydroxybenzoate, water.

Release form

Transparent drops of 1% without color and a smell.

  • 3 ml of drops of 1% in a bottle — 1 bottle with a cover pipette in a box from a cardboard.

Transparent drops of 0,1% without color and a smell.

  • 3 ml of drops of 0,1% in a bottle — 1 bottle with a cover pipette in a box from a cardboard.

Pharmacological action

Nootropic, anti-hypoxemic, tserebroprotektivny, antioxidant action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Drug possesses neurospecific action on a nervous system.

Drops in a nose of Semaks (Semax) have the expressed neurometabolic effect even at use them in small doses. High doses make in addition expressed anti-hypoxemic, antioxidant, neurotrophic and angioprotektivny effect. 4 minutes later at intranasal introduction passes through a blood-brain barrier, and medical action lasts till 24 o'clock at single use.

Influences the processes connected with training and functioning of memory. Strengthens attention in the analysis and training, improves organism adaptation to cerebral ischemia, an anesthesia and other damaging actions. Renders the stimulating effect on bazalnoyaderny cholinergic neurons of a neoncephalon.

Drug also influences the processes of neyronalny death caused by release of nitrogen oxide, a local inflammation, an oxidatic stress and disturbance of food of fabrics. At the gene level activates synthesis of neyrotrofin (the substances responsible for growth and development of nervous tissue).

Makes direct impact on regulation of balance of cytokines and on increase in level of anti-inflammatory factors, causing delay of peroxide oxidation of fats, activation of allocation of a superoxide scavenger and reduction of maintenance of a tsikloguazinmonofosfat.

Drug is almost not toxic and does not show embriotoksichesky, local irritative allergic, mutagen and teratogenic properties.

Pharmacokinetics

It is adsorbed from a mucous nasal cavity, at the same time about 60-65% of active agent are acquired. It is actively distributed in fabrics. In a blood channel is exposed to fast degradation and it is evacuated from an organism by kidneys.

Indications to use

Indications to use of drops of Semaks of 0,1%:

  • states after neurosurgical operations, a craniocereberal injury, an anesthesia;
  • dysmnesia and intellectual processes at damages of a brain of vascular genesis;
  • distsirkulyatorny encephalopathy;
  • the recovery period after a stroke;
  • temporary disorders of cerebral blood circulation and neurotic frustration of a various origin, including radiative effects;
  • improvement of adaptation opportunities in extreme situations;
  • atrophy of an optic nerve;
  • the prevention of mental exhaustion at uniform camerawork during its most intense periods;
  • as nootropic medicine at children for 5 flyings at therapy of weak brain dysfunctions;
  • toksiko-allergic and inflammatory neuritis.

Semaks's use is proved by 1% at the acute period of a stroke of ischemic type.

Contraindications

Contraindications to Semaks's use 0,1%:

  • acute psychoses;
  • the age is younger than 5 years;
  • allergy to drug components;
  • alarming frustration;
  • pregnancy and lactation;
  • spasms in the anamnesis.

Contraindications to use of drops of Semaks of 1%:

  • acute psychoses;
  • allergy to drug components;
  • alarming frustration;
  • spasms in the anamnesis;
  • lactation and pregnancy.

Side effects

At long use emergence of weak irritation mucous nasal cavities is not excluded.

Application instruction of Semaks (Way and dosage)

Medicine is applied intranazalno. It is necessary to store a bottle with the closed cap.

0,1% of a drop in a nose of Semaks, the application instruction

1 drop of solution drug includes 50 mkg of active agent. By means of a stopper pipette no more than 2-3 drops of solution are entered into nasal passes. Increase in a dosage is carried out by introduction of drops several times with intervals 12–15 minutes.

The single dose can dostigat2000 mkg (it is calculated at the rate of 4–30 mkg/kg of weight). The general day dose can reach 5000 mkg (it is calculated at the rate of 8–70 mkg/kg of weight).

The drug is administered daily for 3–5 days, if necessary treatment is prolonged about 2 weeks.

At defeats of an optic nerve of a drop about 3-2 drops are entered into both nasal passes to 3 times a day. The general day dose at this type of pathology makes 600–900 mkg, and treatment duration — 8-10 days.

Also it is authorized to enter solution of drug by method of an intra nasal electrophoresis.

Drops nasal Semaks of 1%

One drop of 1% of solution of drug contains 500 mkg of active ingredient.

At treatment of a stroke of moderate severity for once 3-2 drops of means are entered into each nostril. Similar procedures are carried out to 4 times a day, with a break between instillations at 4 o'clock. The cumulative day dose is equal to 6000-12000 mkg.

At treatment of a heavy stroke for once 4 drops of means are entered into each nostril. Similar procedures are carried out to 5 times a day, with a break between instillations at 3 o'clock. The cumulative day dose is equal to 12000-20000 mkg.

Duration of treatment makes 10 days.

Overdose

Symptoms of overdose did not come to light even at substantial increase of a dosage.

Interaction

Simultaneous use of the intranasal means having local vasoconstrictive effect is undesirable.

Terms of sale

According to the recipe.

Storage conditions

To store in the dark place at a temperature less than 10 °C. To protect from children. Not to freeze.

Period of validity

2 years.

Semaks's analogs

The most widespread analogs of Semaks are given below: Cerebrolysinum, Amilonosar, Ginos, Glycine, Gliatilin, Aminalonum, Deletsit, Biotropil, Intellan, Lutsetam, Priratsetam, Omaron, Bifren, Stamin, Noofen, Fezam, Tserebril, Vinpocetine, Encephabolum, Eskotropil.

To children

At insignificant brain dysfunctions at children of 5 flyings appoint to dig in on 1–2 drops in both nasal passes twice a day. The general day dose makes 200–400 mkg. Treatment duration at children — 1 month.

Zdravzona

  • Semaks 0,1% 3 ml of a drop in nosimgran
  • Semaks 1% 3 ml of a drop in a nose

Drugstore of IFC

  • Semaks drops nazaln. 0.1% of 3 ml, Peptogen INPTS Zaorossiya
  • Semaks drops nazaln. 1% 3 ml, Peptogen INPTS Zaorossiya
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Section: For a nervous system
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Education: Graduated from the Vitebsk state medical university majoring in "Surgery". At university headed Council of students' scientific society. Professional development in 2010 - in "Oncology" and in 2011 - in "A mammology, visual forms of oncology".

Experience: Work in an all-medical network 3 years the surgeon (The Vitebsk hospital of an emergency medical service, Lioznensky TsRB) and in combination the regional oncologist and the traumatologist. Work farm the representative within a year in the Rubicon company.

Provided 3 improvement suggestions on the subject "Optimization of an Antibioticotherapia depending on Species Composition of Microflora", 2 works took prizes in a republican competition review of student's scientific works (1 and 3 categories).
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