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In 1 candle — a sertakonazola nitrate of 300 mg. Vitepsol, suppotsir, silicon dioxide — as excipients.
In 1 g of cream — 20 mg of active agent. Ethylene glycol, saturated glycerides, polyethyleneglycol, palmitostearat, glycerin isostearate, oil paraffin, sorbic acid, water — as excipients.
- Candles vaginal 300 mg.
- 2% solution for external use on 15 ml in bottles.
- Cream of 2% 20 mg.
Pharmacodynamics and pharmacokinetics
In therapeutic doses possesses fungicidal and a fungistasis. Efficiency of action provides existence of a double molecule of substance. The Imidazolny part of a molecule causes disturbance of synthesis of the ergosterol which is the main component of a membrane of a cell of mushrooms and provides fungistatic effect. The petrolthiafoehn structure substitutes tryptophane (irreplaceable amino acid) in a mushroom membrane that leads to death of a mushroom — fungicidal action is carried out.
Shows activity concerning mushrooms of Candida, dermatophytes and other causative agents of infections of skin — gram-positive Staphylococcus spp. and Streptococcus spp. It is active concerning Trichomonas vaginalis.
After putting cream or solution on skin medical concentration is reached in 30 min. and 48 h and more remain. Even at use within two weeks active ingredient is not defined in urine and blood.
At intravaginalny use high concentration in a vagina remain a long time. System absorption at such route of administration is absent.
Indications to use
Suppositories vaginal: candidosis vulvovaginitis.
Hypersensitivity to imidazole derivatives. With care it is applied at pregnancy and at children.
At external use:
At intravaginalny use: passing burning and an itch in a vagina.
Sertakonazol, application instruction (Way and dosage)
Candles Sertakonazol (Zalain) apply intravaginalno, only once. Vaginal suppository is entered, lying on spin as it is possible more deeply, before going to bed. If necessary (if clinical symptoms remain) undertake repeated administration of suppository in a week.
Treatment is carried out also during periods. During treatment it is necessary to abstain from sexual contacts. For prevention of reinfection simultaneous treatment of the sexual partner is recommended.
Cream Sertakonazol (Zalain, Sertamikol) is applied on skin with a thin layer twice a day, occupying the area of healthy skin on 1 cm. For the guaranteed clinical and microbiological treatment duration of treatment has to makes 4 weeks.
Overdose is improbable at any way of use of drug. At accidental hit inside carry out a gastric lavage and if necessary a symptomatic treatment.
Terms of sale
It is released without recipe.
Temperature of storage is up to 25 °C.
Period of validity
Coincidence on the ATH code of the 4th level:
- img src="//medicalmed.us/img/Finalgon-1-110x80.jpg" tppabs="medicalmed.us/wp-content/uploads/2016/05/livarol-1-110x80.jpg">Livarol
- Candide B6
- Metrogil Plus
- Gino-Travogen Ovulum
- Klion-D 100
Zalain (cream and candles), Sertamikol (cream and solution for external use).
The first azolovy antifungal means appeared 30 flyings ago, and today it is the biggest class of drugs. The new generation of azoles of "double classes" exceeding classical imidazoles by efficiency is in recent years developed. Among them — Sertakonazol whose one molecule contains azolovy and petrolthiafoehn group which strengthen action of each other. Drug passed clinical tests and is approved for topical treatment of an epidermophitia of feet, allowed for use for children 12 years are more senior.
Use of topical drug (topical treatment) — the main stage of treatment of mycosis of feet also lasts it till 4 weeks. This drug differs in high activity concerning forms of mushrooms, resistant to classical drugs. Considerably exceeds other anti-mycotic means: Miconazolum, Bifonazol, Ketokonazol, Clotrimazolum. Usually in 1 week at patients symptoms of diseases disappear and about it testify To drug.
- "… In the left armpit candidiasis develops. I always in the first-aid kit have cream Zalain. If to use it at once, without starting a disease, then for couple of days there will be no spot".
- "… Me appointed it at a chromophytosis — on a neck there were brown spots with the shelled skin, they expanded and extended further. It was treated month, everything passed".
- "… Sertakonazol applied ointment at a foot fungus. Helped quickly — the itch, and stratifying of skin disappeared. But for fixing of result the doctor told to use ointment till 1 month".
- "… I use this cream once before visit of a gym and the pool. The doctor recommended to apply preventively".
It is considered that for treatment of the milkwoman means from group of azoles are most effective. In this plan win drugs on the basis of the sertakonazol containing a double molecule therefore they are effective for fast and complex fight against the milkwoman.
- "… I was helped only by candles Sertakonazol, but completed a course of 14 days, that is used 2 candles. There are no problems".
- "… All treatment individually, but very much helped me. Only it also helped, suffered all pregnancy and was treated by different drugs. After the delivery applied 1 candle and all!!".
However also negative responses meet:
- "… Juicy candle. Itch and burning intolerable".
- "… This drug worsened my state! After treatment I had all signs of the milkwoman".
- "… I had an aggravation too".
Gynecologists explain an aggravation of symptoms and strengthening of allocations with the fact that there is a death of a fungus and products of their disintegration "are actively taken out" from a vagina, and in a case to their chronic milkwoman can be very much. At the chronic milkwoman treatment by triple introduction of candles with an interval of week is carried out.
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Sertakonazol surely consult with the attending physician.