Сиган Drug photo

The description is actual on 06.07.2016

  • Latin name: Sigan
  • ATH code: M01AX
  • Active ingredient: Nimesulide + Dicyclomine (Nimesulide + Dicyclomine)
  • Producer: Dzhen Biotek Pvt. Ltd., India


In 1 tablet of Nimesulide of 100 mg and hydrochloride of dicyclomine of 20 mg. Starch corn, lactose, dicalcium phosphate, magnesium stearate, polyvinylpirrolidone, silicon dioxide, krakhmalglikolit sodium, talc as auxiliary components.

Release form

Tablets in a cover No. 4.

Pharmacological action

Anesthetizing and spasmolytic.

Pharmacodynamics and pharmacokinetics


The combined drug having antiinflammatory, analgetic and spasmolytic effect. Nimesulide, inhibiting enzyme of synthesis of prostaglandins, provides analgeziruyushchy effect. Dicyclomine is a spasmolysant, the reducing spasm of muscles of a gastrointestinal tract.


At intake Nimesulide is well soaked up from a gastrointestinal tract. Its concentration in plasma is maximum is defined in 2-3 hours. Communication with proteins of 97,5%. It is metabolized in a liver to active agent of hydroxynimesulide. About 65% of Nimesulide are allocated with urine, other 35% – with a stake. Dicyclomine is also quickly soaked up, and concentration it in blood is reached in 1,5 hours. T1/2 makes 4–5 hours. It is removed mainly by urine (79%) and a stake.

Indications to use


  • Peptic ulcer in an aggravation stage;
  • abnormal liver function and kidneys;
  • impassability of intestines;
  • piloroduodenalny stenosis;
  • acute surgical pathology;
  • cardiospasm;
  • changes of coagulant system of blood;
  • pregnancy;
  • feeding by a breast;
  • alcohol addiction;
  • grippopodobny state;
  • hypersensitivity;
  • age till 6 flyings;
  • tachycardia.

With care it is appointed at glaucoma, adenoma of a prostate, heart failure. At depression of function of kidneys administration of drug is stopped.

Side effects

  • Itch of integuments;
  • erythema;
  • dermatitis;
  • enanthesis;
  • Quincke's edema;
  • the increased perspiration;
  • abdominal pain;
  • meteorism;
  • lock, nausea;
  • drowsiness;
  • dizziness;
  • cholestasia;
  • round ulcer of a stomach;
  • bleeding (rarely);
  • jaundice;
  • dysuria;
  • urination delay;
  • intersticial nephrite (isolated cases);
  • anemia;
  • thrombocytopenia;
  • bronchospasm;
  • asthma attacks;
  • tachycardia;
  • increase of the ABP;
  • feeling of alarm;
  • dreadful dreams;
  • nervousness.

Sigan, application instruction (Way and dosage)

Pill Sigan should be taken after food, with enough water. The recommended doses: adult 100 mg (1 tablet) 2 times a day, to children since 6 on 1/2 tablets 2 times a day. Duration of treatment is up to 15 days.

When developing gastric bleeding administration of drug is immediately stopped. Patients, whose activity is connected with special attention, need to know about a possibility of emergence of dizziness during administration of drug.


Overdose appears drowsiness, nausea, block, pain in epigastriums and a lethargy. Bleeding, arterial hypertension, a renal failure, respiratory depression and a coma can be noted. Dicyclomine overdose at first is shown by excitement, concern, hallucinations, tachycardia, increase of the ABP. Excitement is replaced by oppression of TsNS. The antidote does not exist.


At a concomitant use with acetylsalicylic acid, warfarin and other anticoagulants the risk of bleeding appears. To be careful at purpose of furosemide at patients with renal failures. Drug reduces clearance of drugs of lithium that increases its toxicity. In this regard it is necessary to control lithium level in blood. Sigan increases toxicity of a methotrexate and nephrotoxicity of cyclosporines.

Dicyclomine strengthens action of other holinoblokator (for example, Atropine) that has to be considered at their simultaneous use. Potentiation of effect is not observed at appointment with Digoxin, Glibenclamidum, theophylline, ranitidine or antacids.

Terms of sale

It is released according to the recipe of the doctor.

Storage conditions

Temperature of storage is up to 25 °C.

Period of validity

3 years.

Sigan's analogs

Structural analogs (with the same active agents): Alite, Nanogan, Nigan, Oksigan, Nimuspaz. Maksigan, Kombispazm, Baralginum, Baralgetas, Spazgan, Spazmalgon, Spazmalin have similar effect.

About Sigana

NPVS are well combined with medicines of other pharmacological groups which strengthen action of each other. Efficiency of the combined drugs Renalgan, Kombispazm, Nimuspaz, Spazmalgon containing in addition spasmolysants of various groups is well-known. Among these drugs it is possible to call also tablets Sigan. Judging by responses this drug was often used by patients at painful periods, tension headache, fractures and injuries, diseases of joints and for elimination of a dentagra.

At algodismery many women practiced preliminary reception of this drug in 2 days prior to the beginning of periods and the next 2–3 days. At such mode of reception of pain if appeared, then were expressed much more weakly.

  • "… Mother has a coxarthrosis and for simplification of a state she accepts this drug. Says that reception for the night well anesthetizes it and gives the chance to sleep normally";
  • "... Well kills pain, is in the home first-aid kit just in case — I use them very seldom, situationally";
  • "… When teeth hurt or the head hurts, I take this pill. Efficient, well help".

Patients report also about by-effects of this medicine:

  • "… I have a pseudorheumatism and at severe pains Sigan added a tablet to my continuous treatment. Accepted only 3 times and appeared the century swelled. However, in the childhood I had an allergic reaction to an inoculation";
  • "... Safe tablets do not happen. Personally I have pains in right hypochondrium and bitterness in a mouth after 3-5 days of reception of this drug".


  • Maksigan of 500 mg No. 100 of a tablet
  • Maksigan of 500 mg No. 10 of a tablet
  • Maksigan of 500 mg No. 20 of a tablet
to show still


  • Sigan of a tablet No. 4dzhenom of Biothat (India)


  • Sigan of the tab. No. 4
Section: Anesthetics
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Sigan surely consult with the attending physician.