Signitsef

Сигницеф Drug photo

The description is actual on 16.02.2015

  • Latin name: Signicef
  • ATH code: S01AX19
  • Active ingredient: Levofloxacin (Levofloxacin)
  • Producer: Pro-honey of Exports Pvt. Ltd. (India)

Structure

Active agent – a gemigidrata levofloxacin.

Additional components: sodium chloride, benzalkoniya chloride, Acidum hydrochloricum, sodium hydroxide, gipromelloza, water.

Release form

Solution for infusions and eye drops is on sale in the form of special.

Pharmacological action

Antimicrobic and antibacterial agent.

Pharmacodynamics and pharmacokinetics

Solution for infusions and eye drops Signitsef represent antibacterial and antimicrobic drug. Its active ingredient inhibits DNK-girazu and topoisomerase IV, synthesis of DNA oppresses, interferes with superspiralling and a stitching of ruptures of DNA. Besides, it provokes morphological changes in membranes of bacteria, cytoplasm and a cell wall.

Medicine affects gram-negative and gram-positive aerobes. Also actively influences Chlamydia trachomatis.

Active component of drug in the form of eye drops accumulates in the lacrimal film. Concentration in the lacrimal liquid quickly reaches high rates and keeps for 6 hours.

At use inside quickly and almost it is completely absorbed from a gastrointestinal tract. Well comes to bodies and fabrics: easy, polymorphonuclear leukocytes, mucous bronchial tubes, bodies of urinogenital system, alveolar macrophages. Some part is oxidized or dezatsetilirutsya. It is excreted by kidneys by means of canalicular secretion and glomerular filtering.

Indications to use

Indications to drug use the following:

  • therapy of infections of the adnexal device and front piece of an eye which are provoked by the organisms sensitive to a levofloksatsin;
  • need of prevention of complications after operations in the eyes;
  • local therapy of infections of eyes which are provoked by the microorganisms susceptible to a levofloksatsin.

Contraindications

It is not recommended to use solution for infusions and eye drops Signitsef in case of hypersensitivity to components of drug, damages of sinews at earlier carried out therapy of a hinolonama, and also during the breastfeeding, pregnancy, epilepsy. With care medicine is appointed at children's age.

Side effects

Side reactions are observed only in rare instances. As a rule, they are characterized by weak or moderate severity and pass over time.

The following ophthalmologic frustration are possible: burning in eyes, deterioration in visual acuity, a matting the century, papillary reaction of a conjunctiva, eye pain, conjunctival follicles, an erythema a century, hemoz, swelled a century, an itch, a conjunctival infection, dryness in eyes, photophobia.

In rare instances from immune system allergic and anaphylactic reactions were observed.

From TsNS it is reported about such side effects as dizziness, a headache, drowsiness, paresthesias, fear, confusion of consciousness, motive frustration, weakness, sleeplessness, alarm, hallucinations, a depression, spasms.

From bodies of respiratory system mediastinal and thoracic disturbances, rhinitis are possible.

Besides, it is known of the following probable side reactions:

  • increase of activity of transaminases of a liver;
  • nausea;
  • diarrhea;
  • abdominal pains;
  • hepatitis;
  • vomiting;
  • anorexia;
  • pseudomembranous coloenteritis;
  • hyperbilirubinemia;
  • dysbacteriosis;
  • pressure decrease;
  • tachycardia;
  • vascular collapse;
  • hypoglycemia;
  • hearing disorder, taste, sense of smell and tactile sensitivity;
  • arthralgia;
  • rupture of sinews;
  • tendinitis;
  • mialgiya;
  • muscular weakness;
  • giperkreatininemiya;
  • intersticial nephrite;
  • eosinophilia;
  • leukopenia;
  • agranulocytosis;
  • pancytopenia;
  • hemolitic anemia;
  • neutropenia;
  • thrombocytopenia;
  • hemorrhages;
  • porphyria aggravation;
  • Lyell's disease;
  • persistent fever;
  • rabdomioliz;
  • development of superinfection.

Application instruction (Way and dosage)

The instruction on eye drops Signitsef reports that they are applied during the first two days after emergence of a disease. Medicine is dug in on 1-2 drops in the eye affected with an infection with an interval at 2 o'clock. At most 8 times a day. 2 days later drug begins to be used in the same dose to 4 times a day.

How many therapy lasts, directly depends on weight and features of a disease. As a rule, treatment continues only 5 days.

The patient has to reject the head back, delay a lower eyelid, dig medicine and close eyes. That it did not get to the lacrimal canal and a system blood stream, the inner edge of an eye needs to be pressed for 1-2 minutes a finger. It is impossible to blink. The remains of eye drops are removed a pure napkin without contact with eyes.

The dropper tip when using drug should not touch by centuries or sites near eyes.

If the patient also applies other means to eyes, the interval between their use has to be not less than 15 minutes.

The drug in the form of solution for infusions is administered intravenously kapelno. It is necessary to do it slowly, it is not less than an hour. A dosage – 250-500 mg every day 1-2 times. The exact amount of drug depends on character and disease severity.

Doses for patients with normal work of kidneys:

  • acute antritis: 500 mg daily for 10-14 days;
  • exacerbation of chronic bronchitis: it is necessary to accept 250-500 mg daily for 7-10 days;
  • the complicated and uncomplicated infections of urinary tract: it is necessary to accept 250 mg daily for 7-10 days, if necessary the dosage can be raised;
  • infectious diseases of soft tissues and skin: it is necessary to accept 500 mg twice a day, a course – 1-2 weeks;
  • intraabdominal infection: it is necessary to accept 500 mg daily, a course – 1-2 weeks;
  • community-acquired pneumonia: it is necessary to accept 500 mg daily 1-2 times, a course – 1-2 weeks;
  • bacterial chronic prostatitis: it is necessary to accept 500 mg daily for 28 days;
  • septicaemia/bacteremia: it is necessary to accept 500 mg daily 1-2 times, a course – 1-2 weeks;
  • complex treatment of the forms of tuberculosis steady against drugs, – it is necessary to accept 500 mg daily 1-2 times, a course – till 3 months.

For people with problems of function of kidneys of a dosage decrease according to severity of a disease:

  • – it is necessary to accept indicators of KK of 20-50 ml/min. on 125-250 mg daily 1-2 times;
  • — it is necessary to accept indicators of KK of 10-19 ml/min. on 125 mg every day 1-2 times;
  • KK indicators to 10 ml/min. – need to be accepted on 125 mg in 1-2 days.

Overdose

Toxic action after accidental use in eye drops is excluded as the quantity of a levofloksatsin in a bottle is not enough. And at overdose in case of topical administration manifestations of side reactions can amplify.

Reception of this medicine should be stopped immediately. When using drops of an eye to wash out warm water. In case of overdose at internal use the supporting events are held.

Interaction

Drug increases Cyclosporine semi-removal time.

Signitsef's action is reduced by the means inhibiting motility of intestines, and also magniysoderzhashchy and aluminum-bearing antiacid HP, sukralfat and iron salts. So between their reception it is necessary to observe the minimum interval at two o'clock.

The combination to NPVS and Theophylline increases convulsive readiness, and at interaction with GKS the risk of a rupture of sinews increases.

Removal of a levofloksatsin from an organism is slowed down at the reception of Cimetidinum and drugs inhibiting canalicular secretion.

Terms of sale

Is on sale in all forms of release only according to the recipe.

Storage conditions

Optimum temperature is up to 30 °C. To keep in the dark place, to protect from small children, not to freeze.

Period of validity

The period of validity makes 2 years in the corked bottle. After its opening it is possible to use means at most 1 month.

Signitsef's analogs

Coincidence on the ATH code of the 4th level:

The following analogs of Signitsef are known:

  • Left;
  • Oftakviks;
  • Abifloks;
  • Glevo;
  • Zevotsin;
  • Zolev;
  • Lebel;
  • Levasept;
  • Left dollar;
  • Levokatsin;
  • Levobakt;
  • Levokilz;
  • Levogrin;
  • Levoksa;
  • Left nickname;
  • Left xyhoney;
  • Left phlox;
  • Levolet;
  • Levofloxacin;
  • Left poppy;
  • Left herds;
  • Levofloksatsin-Zdorovye;
  • Left Torahs;
  • Levofloksatsin-Kredofarm;
  • Levofast;
  • Levoflotsin;
  • Left-FC;
  • Levotsel;
  • Leflotsin;
  • Levotsin;
  • Lefsan;
  • Levotsin-N;
  • Loksof;
  • Leflok;
  • L-phlox;
  • Leflok-Darnitsa;
  • Novoks;
  • Leflokad;
  • Potant-Sanovel;
  • Remediya;
  • Taygeron;
  • Floksium.

The majority of the specified drugs are on sale in the form of tablets and special solution for infusions.

About Signitsef

About eye drops and solution for infusions, as a rule, positive. Patients note efficiency of this drug. Among the negative moments About Signitsef call only a few high price, and also the fact that it cannot be applied at pregnancy and feeding by a breast.

Zdravzona

  • Signitsef of 0,5% of a drop eye 5 ml bottle-kapelnitsapromed of Exports/Sentiss of Farm

Drugstore of IFC

  • Signitsef of a gl.kapla of 0,5% 5 ml, Oooindiya's Pro-honey
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Apteka24

  • Signitsef

BIOSPHERE

  • Signitsef of 0,5% 5 ml of a drop glazn.sentiss Pharma Private Limited (India)
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Section: For eyes Antimicrobic
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Signitsef surely consult with the attending physician.