Sildenafil

• Structure
• Release form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications to use
• Contraindications
• Side effects
• Application instruction of Sildenafil (Way and dosage)
• Overdose
• Interaction
• Terms of sale
• Storage conditions
• Period of validity
• Sildenafil for women
• Analogs
• Responses

Structure

Contains 70,24 mg of a sildenafil of citrate that is equivalent to 50 mg of a sildenafil, or 140,48 mg of a sildenafil of citrate that is equivalent to 100 mg of a sildenafil. From excipients: lactoses monohydrate, cellulose microcrystallic, povidone, magnesium stearate, titanium dioxide macrogoal, indigo carmine.

Release form

Tablets, coated in the blister on 1 or 4 tablets.

Pharmacological action

The means raising an erection.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Drug recovers the lost reaction to sexual excitement. The normal erection is impossible without allocation of an oxide of nitrogen in a cavernous body of a penis which activates enzyme guanylate cyclase. Activation of this enzyme attracts increase in level of a specific nucleotide — a cyclic guanozinmonofosfat (tsGMF). This nucleotide is necessary for relaxation of muscles of a cavernous body therefore the blood stream in a penis raises. Sildenafil — the selection inhibitor of phosphodiesterase 5 under the influence of which there is a disintegration of tsGMF. Thus, Sildenafila citrate influences increase in a krovenapolneniye in a generative organ. At researches 72% of patients had a full sexual intercourse. Effect of this medicine begins in 1 hour and 3-4 hours last.

Pharmacokinetics

Absorption: it is quickly soaked up, bioavailability makes 41%. The maximum concentration in plasma are observed on average in 1 hour after reception on an empty stomach. Alcohol intake and greasy food slows down absorption.

Distribution: contacts proteins of plasma, evenly gets into fabrics.

Metabolism: it is metabolized by liver enzymes. The main metabolites are metabolized further, and the elimination half-life makes them 4 hours.

Removal: metabolites are generally removed with a stake (80%) and urine (13%).

Indications to use

Disturbances of an erection of various genesis (psychogenic, organic or mixed).

Contraindications

• hypersensitivity to drug;
• deformations of a penis;
• simultaneous treatment by nitrates;
• tendency to bleedings;
• renal failure and cirrhosis;
• severe form hypo - and hypertensia;
• unstable stenocardia;
• stroke or myocardial infarction (the first 6 months);
• arrhythmia.

Side effects

Possible side reactions are specified on occurrence frequency.

• headache, inflow to the person;
• vision disorder;
• nose congestion;
• skin rash;
• dyspepsia;
• infections of urinary tract;
• diarrhea;
• dizziness.

Among other by-effects it is possible to note: a faint, a sleep disorder, a ring in ears, a photophobia, hypotension, tachycardia, stenocardia attacks, strengthening of cough, increase in quantity of a phlegm, dryness in a mouth, thirst, rectal bleeding, a frequent urination, hypostasis of generative organs, a mialgiya, arthritis. In researches these reactions were noted at reception of a sildenafil of 100 mg.

Application instruction of Sildenafil (Way and dosage)

Pill is taken inside in one hour prior to intimacy. For adults a single dose — 50 mg a day. Taking into account portability and efficiency of drug, it is possible to reduce a dose to 25 mg or to increase up to 100 mg that is the maximum single dose. For elderly people it is not necessary to change a standard dosage.

The application instruction of Sildenafil for different categories of patients

At a renal failure: in the presence of a renal failure easy and moderate severity the dose does not change. The heavy renal failure needs reduction of a dose to 25 mg.

At an abnormal liver function: at cirrhosis use of drug begin 25 mg with a dose.

At use of other medicines: at use of CYP3A4 inhibitors the dose makes 25 mg. The exception makes ritonavir with which joint reception is not recommended.

At use by patients of blockers of alpha adrenoceptors a dose — 25 mg as there is a danger of development of orthostatic hypotension.

Drug does not provide indications to patients till 18 flyings. To elderly patients the dose does not change.

Overdose

At overdose side effects are shown more obviously. The dose of 200 mg is not more effective, however the frequency of emergence of reactions is higher. Administration of drug by volunteers in a dose of 800 mg led to the fact that the frequency of emergence of side reactions and degree of their weight increased. At treatment apply symptomatic therapy.

Interaction

Erythromycin, ketokonazol and Cimetidinum reduce removal of a sildenafil with increase of its content in blood. Together with Sodium nitroprussidum the antiagregantny effect of the last amplifies.

At a combination to organic nitrates their hypotensive effect amplifies that can lead to a lethal outcome.

The concomitant use with hypoglycemic medicines and beta adrenoblockers is contraindicated that it can also pose hazard to life.

Terms of sale

It is released according to the recipe.

Storage conditions

To store in the dry place. Temperature of storage is not higher 25 ° - 300C.

Period of validity

Period of validity — 2 years.

Sildenafil for women

Drug is made for women under brands: Ladygra, Womenra, Femalegra. Active component of tablets is also the sildenafila the citrate equivalent to 50 mg or 100 mg of a sildenafil.

It is applied to increase of sexual activity and sensitivity during intimacy. A pill on 50 mg is taken in one hour prior to the planned sexual intercourse. Taking into account efficiency the dose increases (100 mg by reception) or decreases (25 mg). At the same time the maximum dose — 100 mg.

Side reactions at administration of drug are possible: headache, dizziness, nausea, nose congestion, photophobia, disturbance of clearness of sight.

It is necessary to consider that drug makes negative impact on a hysteromyoma. In this connection, the issue of its use is resolved by the gynecologist.

Sildenafil's analogs

Viagra, Vigrande, Vizarsin, Dinamiko. Analogs have the same structure: in terms of sildenafit — 25,0 mg, 50,0 mg or 100,0 mg.