Силибор Drug photo

The description is actual on 02.10.2015

  • Latin name: Siliborum
  • ATH code: A05BA03
  • Active ingredient: Mix of flavonoids (Silibininum, silikristin, silidianin) from extract of a thistle of spotty Silybum marianum
  • Producer: Health (Ukraine)


Siliborum max. contains in one capsule 35, 70 or 140 mg of Siliborum. When using Silymarinum its quantity undertakes in terms of 100% the maintenance of a bag of flavolignan (Silymarinum). Calcium stearate stearate and monohydrate of lactose monohydrate acts as excipients krospovidon, and also.

Potato starch acts as excipients in tablets, sodium starch is glikolit, calcium stearate, monohydrate of lactose, a gipromelloz, titanium dioxide, dye of yellow Sunset color (E110).

Release form

Siliborum 35, 70 i140 is issued in capsules which on physical properties are firm and gelatinous, have caramel color. In capsules there is a mix from granules and powder which usually light yellow or brownish color, accumulation of agglomerates of particles is possible. There can be at one of the parties of a capsule a trademark — ZT.

Also drug is issued in tablets of orange or brownish color with admissible marble impregnations. They have a cover and in cross in a section 2 layers are visible.

Pharmacological action

Gepatoprotektorny properties, and also antioxidant activity are characteristic of drug, it is capable to stimulate synthesis of protein and to normalize an exchange of phospholipids.

Pharmacodynamics and pharmacokinetics

Gepatoprotektorny influence is based antioxidant and a membrane of the stabilizing activity of drug. Improvement of a metabolism in hepatocytes goes on the way of normalization an exchange of phospholipids and stimulation of synthesis of structural and functional proteins, a glycogen and RNA. Protection against penetration of gepatotoksichny substances into hepatocytes accelerates recovery processes of a liver.

Characteristic of pharmacokinetics of drug

Process of absorption of a digestive tract happens slowly, the period of semi-absorption makes about 130 minutes. The metabolism is carried out in a liver on means of conjugation. About 40% of Silymarinum which is allocated together with bile pass into a cycle of portal and biliary circulation of bile acids. Removal mainly with bile in the form of sulfates and glucuronides, the rest — with urine. In an organism and fabrics does not collect. A drug elimination half-life — till 6 o'clock.

Indications to use

The tablets Siliborum are usually appointed:

  • at chronic hepatitises, and also cirrhosis of various origin (in complex therapy);
  • at a steatogepatoza;
  • for prevention of threat of negative external impact of hepatotoxic substances and prolonged use of medicines which worsen a functional condition of a liver.


  • hypersensitivity to active and auxiliary components of drug;
  • the children's age – patients is younger than 6 years.

Side effects

  • dispepsichesky frustration: diarrhea;
  • allergic reactions: skin rash, itch;
  • increase in diuresis;
  • dizziness (most often — at prolonged treatment).

Attention! If any of undesirable collateral symptoms is found, then it is necessary to see a doctor for dose adjustment or full drug withdrawal.

Siliborum, application instruction (Way and dosage)

Siliborum should be accepted to food, and not to chew and wash down with the small volume of water. The dosage for various groups of patients at treatment of various diseases of a liver differs:

  • adults and children of 12 flyings — on 210 mg for 3 receptions during the day;
  • patients with severe forms of diseases: the daily dose if necessary can be increased to 420 mg for 3 receptions;
  • children at the age of 6 - 9: 70 mg at one time in days;
  • children of 9-12 years – 140 mg for 2 receptions during the day.

The standard course of treatment has to last not less than 1 month, to destination the attending physician can last till 3 months. It is allowed to repeat therapy 1-2 months later.

As a prophylactic

Daily dose — 70 mg 1-2 times a day. Reception duration – till 1 month.


Earlier cases of reception of superdoses of Siliborum were not registered and described.

The first measures at overdose by drug

At first it is necessary to cause vomiting, to accept Absorbent carbon, if necessary — to carry out symptomatic therapy.


Clinically significant reactions of medicinal interaction with other known drugs are not revealed.

Terms of sale

It is released without recipe.

Storage conditions

It is recommended to store in the dry cool place protected from sunshine (temperature within 8 ˚ - 25tselsiya). Besides, it is necessary to find the place out of access for children.

Period of validity

Expected period of validity – two years.

At pregnancy and a lactation

Therapy can be carried out only on condition of potentially bigger advantage for mother, than presumable negative impact on the child or a fruit. In addition, control of the doctor since increase in diuresis which is caused by insignificant diuretic influence, inherent for flavonoids, is possible is necessary.


  • Silimar;
  • Silibininum;
  • Rosilimarin.


  • Siliborum of the 140th capsule of 140 mg No. 20 Health (Ukraine, Kharkiv)
  • Tablet Siliborum coated 35 mg No. 25 Health (Ukraine, Kharkiv)
  • Siliborum of the 70th capsule of 70 mg No. 20 Health (Ukraine, Kharkiv)


  • Siliborum 140 kaps.140mg No. 20 Health
  • Siliborum 140 kaps.140mg No. 20 Health
  • Siliborum 140 kaps.140mg No. 20 Health
Section: For a liver
in more detail

Education: Graduated from the Nikolaev national university of V. A. Sukhomlinsky, gained the diploma of the specialist with honors as "An embryologist, a cytologist, a histologist". Also, the human physiology and animals, the teacher of biology" graduated from a magistracy majoring in ". The course on discipline "Pharmacology" is with honors passable.

Experience: Worked as the senior laboratory assistant of department of Physiology and biochemistry of the Nikolaev national university of V. A. Sukhomlinsky in 2010 - 2011.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Siliborum surely consult with the attending physician.