Sofradeks

Софрадекс Drug photo

The description is actual on 30.05.2016

  • Latin name: Sofradex
  • ATH code: S03CA01
  • Active ingredient: Gramicidin C, Dexamethasone, Framycetinum (Gramicidin S, Dexamethasone, Framycetin)
  • Producer: Aventis Pharma (India), Sanofi India Limited (India)

Structure

0,05 mg of gramicidin, 0,5 mg of dexamethasone, 5 mg of Framycetinum are a part of drops (1 ml). Auxiliary connections: lithium chloride, sodium citrate, monohydrate of citric acid, ethanol of 99.5%, feniletanol, polysorbate 80, for and water.

Release form

Ear drops of Sofradeks are issued in the bottles having a dropper and made of dark glass of 5 ml.

Sofradeks eye drops are also issued in bottles with a dropper of dark glass, of 5 ml.

Pharmacological action

Medicine has antipruritic, antiallergic, antibacterial and antiinflammatory effect.

Pharmacodynamics and pharmacokinetics

Medicine of Sofradeks has bactericidal and antibacterial effect of a wide range at the expense of gramicidin and Framycetinum, shows activity in relation to such gram-positive and gram-negative microorganisms as:

  • Staphylococcus epidermidis and aureus;
  • Streptococcus pyogenes, pneumoniae and faecalis;
  • Escherichia coli;
  • Proteus spp.;
  • Klebsiella spp.;
  • Pseudomonas spp., etc.

Antiinflammatory, antiallergic and antipruritic impact is exerted by a glucocorticoid dexamethasone. As a result of an instillation in an eye pain, burning decrease, there is a photophobia, dacryagogue and other symptoms characteristic of the pathological processes caused by the corresponding activators. Besides, it is also effective at adenoides.

Pharmacokinetics

  • Topical administration leads to low system absorption.
  • Framycetinum sulfate is soaked up by the inflamed skin or through open wounds. Coming to a system blood stream, 2-3 hours are exposed to fast removal by kidneys with half-life in not changed look.
  • Dexamethasone is quickly absorbed from a gastrointestinal tract, half-life — 3,16(6) hours.

Indications to use

Drops for eyes of Sofradeks usually appoint at superficial bacterial infections of eyes with an inflammatory or allergic component, and also at a blepharitis, the infected eczema a century, barley, allergic conjunctivitis, rosacea keratitis, a sclerite, an episcleritis, an iridocyclitis, an iritis.

Ear-drops are effective at acute or chronic outside otitis.

Contraindications

  • virus, for example, herpes infections;
  • fungal infections;
  • tuberculosis;
  • glaucoma;
  • purulent inflammation of tissues of eye;
  • hyperemia of an eye of an unknown etiology;
  • supersensitivity;
  • perforated tympanic membrane (for ear drops).

Side effects

  • irritation, burning, itch, pain, dermatitis in the place of application;
  • the increased intraocular pressure;
  • subkapsulyarny cataract (it is possible at long use);
  • thinning of a cornea – is more often at diseases of a cornea, sclera.

Ear and eye drops of Sofradeks, application instruction (Way and dosage)

In ophthalmology

It is necessary to use drops for eyes 6 times and more (in day) on 1–2 drops. On 2–3 drops dig in in an ear 3–4 times a day. The application instruction of Sofradeks assumes a 7-midnevny course of treatment.

Attention! For children of chest or younger age the dosage has to be selected individually and drug has to be used with extra care as high doses and long therapy can cause undesirable system effects.

Use in the LOR-expert

It is necessary to dig in 2-3 cap in outside department of acoustical pass. 3-4 times a day, or — it is possible to put the gauze tampon moistened with solution.

Drops in ears of Sofradeks apply no more than 7 days, an exception – cases of visible positive dynamics. It is necessary to remember that GKS mask the masked proceeding infections, long use of antimicrobic drugs promotes development of steady flora and superinfections.

Use at adenoides

Scheme of treatment: it is necessary to dig in drops in a nose within 4-6 days on 6-8 cap. Then to clean a long viral infection long therapy by Tsikloferon (10-15 days) in the form of inhalations via the nebulizer is necessary.

Overdose

At prolonged topical administration of high doses emergence of system effects is possible, in that case – the symptomatic treatment is necessary.

If it was accepted orally in 10 ml of solution (contents of 2 bottles), then emergence of side reactions is improbable.

Interaction

It is not necessary to combine Framycetinum sulfate with other antibiotic means having ototoksichesky and nephrotoxic effects (for example: Streptomycin, Gentamycin, Monomycinum, Kanamycinum).

Terms of sale

In a drugstore it is necessary to show the recipe.

Storage conditions

Temperature which is not exceeding +25 °C. Out of access for children.

Period of validity

24 months. After packaging opening – less than 1 month.

Special instructions

Due to the temporary loss of clearness of sight, it is not necessary to take right after procedure of an instillation the wheel of a car, to get to work with a difficult technique or machines.

To children

For children 7 years are younger drug is contraindicated as oppression of function of epinephral glands is possible.

The child can dig in Sofradeks in a nose at adenoides, remembering that therapy by antiviral drugs will be required further.

There are analogs differing in the list of active agents:

  • Drops glaz./ushn. Dexonum (is absent — gramicidin);
  • Drops glaz./ushn. Dzhenodeks (only dexamethasone, additional active connections — polymyxin B, chloramphenicol matches);
  • Drops glaz./ushn. Kombinil Duo (only dexamethasone, additional active agent — ciprofloxacin matches).

About Sofradeks

About Sofradeks positive, the people applying it at infectious-inflammatory diseases especially praise drug. Eye drops in 4-5 days cope with a barley problem, and ear – with acute and chronic outside otitis. There are of course also shortcomings – possible tingling and an itch, increase of intraocular pressure.

Sofradeks's price where to buy

Medical portals offer the best options where to find eye and ear drops of Sofradeks which price will be most available. The price in Ukraine fluctuates within 30-43 UAH, in the Russian Federation it is possible to buy drug approximately for 310 rub.

Zdravzona

  • Sofradeks 5 ml of a drop eye/ear

Drugstore of IFC

  • Sofradeks kap.gl/ushn. 5 ml, Aventis/Hoechst Marion Rousselindiya
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Apteka24

  • Sofradeksaventis Pharma (France)

BIOSPHERE

  • Sofradeks 5 ml of a drop glazn./ushn.
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Section: For eyes For ears
in more detail

Education: Graduated from the Nikolaev national university of V. A. Sukhomlinsky, gained the diploma of the specialist with honors as "An embryologist, a cytologist, a histologist". Also, the human physiology and animals, the teacher of biology" graduated from a magistracy majoring in ". The course on discipline "Pharmacology" is with honors passable.

Experience: Worked as the senior laboratory assistant of department of Physiology and biochemistry of the Nikolaev national university of V. A. Sukhomlinsky in 2010 - 2011.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before use of medicine of Sofradeks surely consult with the attending physician.
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