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Finasterid's tablets — finasterid, magnesium stearate, talc, sodium carboxymethylstarch, gelated starch, MKTs, monohydrate of lactose, titanium dioxide, a macrogoal, monohydrate of lactose, a gipromelloz.
Tamsulozin's capsules — a tamsulozina a hydrochloride, calcium stearate, copolymer of ethyl acrylate of methacrylic acid, triethyl citrate, talc, titanium dioxide, gelatin, iron dye.
Finasterid's tablets of 5 mg in a film cover in the form of a triangle of white color, with the rounded-off ends, inodorous.
Tamsulozin's capsules of 0,4 mg in a gelatinous cover to a capsule with modified fulvous color, the size No. 2. Lid: opaque, brown color.
Set of tablets and capsules in the blister packaging on 5 pieces in a cardboard pack No. 30 and 60.
Anti-androgenic, alpha and adrenoceptor blocking.
Pharmacodynamics and pharmacokinetics
Tamsulozin competitively and selektivno blocks the postsynaptic adrenoceptors which are located in smooth muscles of a neck of a bladder, prostate and part of an urethra and body of a bladder that allows to lower a tone of smooth muscles of these bodies and to improve functions of a detruzor of a bladder. As a result of it the symptoms of irritation and obstruction connected with high-quality growth of ferruterous tissue of prostate gland decrease. The medical effect comes in 2 weeks of regular administration of drug. Thanks to sharp selectivity drug does not cause in patients of clinically significant change of the ABP.
Finasterid — specific inhibitor of enzyme of reductase which actively participates in transformation of testosterone in an active androgen — dihydrotestosterone (DGT). Functioning and growth of a prostate (hypertrophied fabric including), is defined directly by process of transformation of testosterone into DGT. Treatment by Finasterid for the short period reduces concentration of DGT in blood almost by 70% that promotes reduction of volume of a prostate. One-time administration of drug in a dose of 5 mg reduces concentration of DGT in blood in 24 hours by 75% which returns to initial level within 7 days.
It is actively soaked up in a small intestine, meal slows down absorption. Possesses high bioavailability (okolo100%). The maximum concentration in blood at a single dose is reached in 6 hours. Equilibrium concentration at a multiple dose of capsules of Tamsoluzin is reached for the fifth day, at the same time, its maximum concentration 2-3 times higher, than in case of a single dose. Communication with blood proteins high (about 99%).
Tamsulozin slowly is metabolized, biotransformation happens in a liver to formation of the active metabolites possessing selectivity to A-adrenoceptors. The considerable part of active agent is in blood in not changed look. Tamsulozin and the formed metabolites are removed by kidneys. An elimination half-life — 10-13 hours.
It is quickly soaked up from a gastrointestinal tract, at the same time, meal influences Finasterid's absorption does not render. Reaches the maximum concentration in blood in 2 hours. Absorption in a gastrointestinal tract after reception comes to the end in 6 hours. Finasterid's bioavailability makes about 80%.
Gets through GEB. Finasterid biotransformirutsya in a liver by oxidation to a number of metabolites. Removal happens through kidneys (about 40%) and intestines (50-60%). An elimination half-life — 6 hours.
Indications to use
Treatment of a benign hyperplasia of a prostate.
High sensitivity to drug, in the anamnesis postural hypotension, a renal failure, the expressed liver failure, intolerance of a galactose.
To take with caution at a liver disease, high risk of development of an uropathy, when planning operational removal of a cataract.
Women of reproductive age and especially pregnant need to avoid any contact with the crushed Finasterid's tablets and with semen of the man at which treatment there is Finasterid.
Collateral manifestations at Tamsulozin's reception: hypersensitivity, dizziness, headache, tachycardia, postural hypotension, rhinitis, nausea, abdominal pain, vomiting, diarrhea, lock, skin itch, rash.
Collateral manifestations at Finasterid's reception: decrease in a libido, erectile dysfunction, increase in mammary glands, disturbance of an ejaculation, pain in testicles.
Sonirid Duo, application instruction (Way and dosage)
Both drugs are intended for daily reception in a dose 1 capsules of Tamsulozin and 1 tablet, Finasterida once a day after food, time is desirable in one and too. Not to chew, swallow of a capsule entirely. Drug is accepted is long. At emergence of side reactions of the patient it is necessary to transfer to mono treatment by Finasterid and to return to the combined reception mode when strengthening symptoms of DGPZh.
There are no clinically expressed symptoms of overdose by Tamsulozin. Theoretically, in case of a single dose of a dose, therapeutic considerably exceeding, arterial hypotension can be observed.
Joint reception of Tamsulozin with Cimetidinum can increase Tamsulozin's concentration in blood, and reception with furosemide reduces it. Warfarin and Diclofenac increase the speed of removal of Tamsulozin. Joint reception of Tamsulozin with HP for the general anesthesia or other drugs - α1-адреноблокаторами can strengthen hypotensive effect of these HP.
Terms of sale
According to the recipe.
At a temperature not above 25 °C.
Period of validity
Sonirid Duo's analogs
Coincidence on the ATH code of the 4th level:
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