Spazmol

Спазмол Drug photo

The description is actual on 22.07.2016

  • Latin name: Spasmol
  • ATH code: A03AD02
  • Active ingredient: Drotaverinum (Drotaverine)
  • Producer: JSC Farmstandart-Leksredstva, Pharmstandard-UFAVITA (Russia)

Structure

In 1 tablet of 40 mg of Drotaverinum. Lactose, potato starch, povidone, calcium stearate, stearic acid as auxiliary components.

In 1 ml of solution of Drotaverinum of 20 mg.

Release form

Solution for injections of 20 mg/ml in ampoules on 2 ml.

Tablets of 40 mg.

Pharmacological action

Spasmolytic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The myotropic spasmolysant eliminating a spasm of unstriated muscles of bodies of a gastrointestinal tract and an urogenital path. Preferential action on zhelche-and urinary tract, bodies of a gastrointestinal tract, a uterus and less expressed influence on CCC is noted.

The mechanism of action is reduced to accumulation in tsAMF cell that finally promotes reduction of concentration of C2+ in a cell which participates in muscular contraction as its transport in extracellular space is stimulated. Reduces a peristaltics of intestines and reduces a physical activity of internals. Moderately expands vessels. If to compare to a papaverine, then this drug has stronger and long spasmolytic action. It is recommended to use when there are contraindications to use M-holinoblokatorov (glaucoma, prostate adenoma). This drug is used quickly for stopping of a spasm and a pain syndrome.

Pharmacokinetics

After intake it is well absorbed. Bioavailability high — 100%. The maximum concentration is defined in blood in 2 hours. Gets into smooth muscle cells. For 98% contacts proteins of plasma. The elimination half-life makes 8-10 h, and in 3 days is almost completely brought out of an organism, more by kidneys, it is less — with bile.

Indications to use

Treatment of states and pain syndrome which are connected with a spasm of smooth muscles:

  • cholelithiasis;
  • gastroduodenit;
  • cholecystitis and spasms of a gall bladder;
  • peptic ulcer;
  • nephrolithiasis;
  • postcholecystectomy syndrome;
  • kardio-and pylorospasm;
  • proctitis;
  • spastic colitis;
  • postoperative gripes;
  • vasospasm (peripheral and brain);
  • the raised uterus tone;
  • algodismenoreya;
  • uterus pharynx spasm in labor;
  • long disclosure of a pharynx of a uterus;
  • the menacing abortion;
  • puerperal pains;
  • carrying out tool researches.

Contraindications

  • liver/renal failure;
  • arterial hypotension;
  • AV blockade of the II-III degree;
  • heart failure;
  • cardiogenic shock;
  • hypersensitivity.

With care it is appointed at suspicion to atherosclerosis of coronary arteries, hypotonia, a prostate hyperplasia, at pregnancy (the I trimester) and lactations, glaucoma.

Side effects

  • decrease in the ABP;
  • headache;
  • heartbeat;
  • dizziness;
  • sleeplessness;
  • perspiration;
  • lock;
  • nausea;
  • feeling of heat;
  • allergic reactions.

Patients with a lactose intolerance have complaints from a gastrointestinal tract.

Spazmol, application instruction (Way and dosage)

Pill is taken inside, swallowed entirely, washing down with water. The adult — on 40-80 mg to 3 times a day. Maximum dose of 240 mg.

The dose at children decreases according to age: till 6 flyings — 10-20 mg 1-2 times a day, from 6 to 12 flyings — 20 mg. Duration of reception is defined by the doctor, but should not exceed 2 weeks.

Solution is entered intramusculary or subcutaneously 40-80 mg to 3 times a day. At hepatic and renal colic use intravenous administration on 40-80 mg. At in introduction of the patient has to lie as there is a risk of a collapse.

Overdose

Overdose is shown by decrease in excitability of a cardiac muscle, conductivity disturbance. The cardiac standstill and breath is possible. The symptomatic treatment is carried out.

Interaction

Drotaverinum weakens effect of a levodopa. At appointment together with tricyclic antidepressants, procaineamide and quinidine the expressed decrease in the ABP is noted. Strengthens action of Bendazolum, papaverine, Nospanum and other spasmolysants. Reduces ability of morphine to cause a spasm of zhelchevyvodyashchy ways. Phenobarbital strengthens spasmolytic effect of Drotaverinum.

Terms of sale

It is released without recipe of the doctor.

Storage conditions

Temperature is up to 25 °C.

Period of validity

4 years.

Analogs

Coincidence on the ATH code of the 4th level:

Bioshpa, Droverin, Nospanum, Spazoverin, Spazmonet, Vero-Drotaverin, Nicoverinum, Papaverine, Mebeverin.

About Spazmole

Myotropic spasmolysants are also traditionally used long ago in gastroenterology for removal of a pain syndrome. Analyzing responses of patients, it is possible to draw a conclusion that most often a pill Spazmol was taken at diseases of a gall bladder, a spastic colitis, gastritises and a peptic ulcer, painful monthly, and some patients — at a headache. Effect of drug was estimated differently, however there are more positive responses.

  • "… Always used burdens - sing, tried spazmol and found out that in the same way works";
  • "… Successfully replaces burdens-pu!";
  • "… Effective, not expensive, quickly kills pain";
  • "… During monthly always the stomach very much hurts, accidentally bought in a drugstore and is very happy";
  • "… Inexpensive analog of Nospanum. Helps me at a headache and always is in my first-aid kit";
  • "… Found out that spazmol helps also at a dentagra".

Some note that mebeverin is more effective and seldom causes system side reactions, does not give atropinopodobny effects. Besides, the release form providing the prolonged action is had.

For receiving the greatest effect all drugs weakening smooth muscles of bodies of a gastrointestinal tract (which treats and spazmol), it is recommended to accept on an empty stomach. It should be noted lack of selectivity of effect at this drug (in other, as well as at all myotropic spasmolysants which affects all smooth muscles) and ability to cause hypomotor dyskinesia and hypotonia of sphincters of a digestive tract at prolonged use. It is necessary to remember that reception of this drug in high doses can be followed by expansion of brain vessels, reduction of the general peripheric resistance, decrease in the system ABP. Therefore it is necessary to apply it in the therapeutic doses which are not influencing indicators of the central hemodynamics and it is short-term (situationally, or from 5 to 14 days).

Zdravzona

  • Spazmol No. 20 of a tabletkifarmstandart-Leksredstvo of joint stock company
  • Spazmol No. 100 of a tabletkifarmstandart-Leksredstvo of joint stock company
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Apteka24

  • Spazmolak kaps. No. 20 Institute Rosel (Canada)

BIOSPHERE

  • Spazmolizin of 40 mg No. 10 supp.farmaprim SRL (Moldova)
to show still
Section: Gastrointestinal
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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