Spiramitsin-Vero

Спирамицин-Веро Drug photo

The description is actual on 29.03.2015

  • Latin name: Spiramycin-Vero
  • ATH code: J01FA02
  • Active ingredient: Spheromycinum (Spiramycin)
  • Producer: Veropharm of joint stock company (Russia)

Structure

In 1 tablet Spheromycinum of 3 million ME. MKTs, poliplasdon, primogel, povidone, magnesium stearate, silicon dioxide, Opadry II as excipients.

In 1 bottle of Spheromycinum adipate of 1,5 million ME.

Release form

Tablets, lyophilisate for preparation of solution for in/in uses.

Pharmacological action

Antibacterial.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Spheromycinum — an antibiotic a macrolead. Has bacteriostatic action, bactericidal — in high doses. Reversibly contacting subunit 50S of microorganism ribosomes, suppresses synthesis of protein in a cell. More long-term antibacterial effect, unlike other macroleads, is explained by the fact that it connects to three domains of subunit. In high concentration collects in a bacterial cell.

Are sensitive to drug: Staphylococcusspp., Neisseriameningitidis, Listeriamonocytogenes, Neisseriagonorrhoeae, Corynebacteriumdiphtheriae, Streptococcusspp., Bordetellapertussis, Mycoplasmapneumoniae, Legionellapneumophila, Chlamydiaspp., Clostridiumspp., Treponemaspp., Leptospiraspp., Toxoplasmagondii, Campylobacterspp.

Are steady: Pseudomonas spp., Streptococcus pneumonia, Enterobacteriaceae spp.

Pharmacokinetics

Absorption comes from a gastrointestinal tract not completely. After reception of 2 tablets Cmax — 3,3 mkg/ml. Differs low (10%) in linkng with proteins of plasma. Well gets into saliva, lungs, almonds, paranasal sinuses, bones. Does not get through GEB. Gets through a placental barrier — into fruit blood concentration of drug of 50% of concentration in mother's blood. It is metabolized in a liver, its metabolites are active. It is removed mainly with bile and it is insignificant with urine. T1/2 about 8 h after intake of 1 tablet.

Indications to use

Contraindications

  • children's age;
  • feeding period breast;
  • liver failure;
  • deficit glyukozo-6-fosfatdegidrogenazy;
  • hypersensitivity.

Side effects

  • pseudomembranous colitis, nausea, vomiting, ulcer esophagitis, cholestatic hepatitis;
  • passing paresthesias;
  • thrombocytopenia, acute hemolysis;
  • lengthening of an interval of QT;
  • Quincke's edema, rash, itch, it is rare — an acute anaphylaxis.

Application instruction Spiramitsin-Vero (Way and dosage)

Is accepted inside. Adults — 2-3 tab. on 3 million ME the day divided into 2-3 receptions. MS dose of 9 million ME.

For the purpose of prevention of the meningitis caused meningokokky take 1 pill (3 million ME) a day within 5 days.

In/in kapelno only adult: contents of a bottle are dissolved in 4 ml of water for injections + 100 ml of 5% of solution of a dextrose.

At pneumonia each 8 h appoint 1,5 million ME.

The application instruction Spiramitsin-Vero contains information that at a renal failure dose adjustment is not carried out.

Overdose

Cases of overdose are not described. Strengthening of side effects is possible. The antidote does not exist. The symptomatic treatment is recommended.

Interaction

Spheromycinum with care is appointed together with ergot alkaloids.

Does not interact with Cyclosporine or Theophylline.

At purpose of drug together with a combination the Levodopa + Karbidopa is marked out increase in time of semi-removal of the Levodopa.

Terms of sale

It is released according to the recipe.

Storage conditions

It is not higher than 250 Pages.

Period of validity

2 years.

Use at pregnancy

Spiramitsin-Vero according to indications is applied at pregnancy. Teratogenic effect of drug is not revealed. During a lactation it is contraindicated to apply it as it can be allocated with milk. During this period breastfeeding stops.

At hospital pneumonia at pregnant drugs of the choice are cephalosporins of the last generations, clavulanate, from reserve antibiotics: Spheromycinum, Clindamycin, Vancomycinum.

Schemes of purpose of Spheromycinum at this disease are various. It is applied in the form of tablets on 3 million ME 3 r / days, in the form of infusions of 3 million ME 3 r / by days in / century. Appointment in the first 2-4 days in the form of infusions, and then orally 7-10 days is possible. And parenteral (in/in) prescription of antibiotics at treatment of pneumonia has no advantages before peroral.

At pyelonephritis at pregnant women drug is appointed on 1.5-3 million ME 3 times a day. At an ureaplazmenny infection at pregnant women also appoint this drug, however data on identification of mycoplasmas and ureplazm resistant to Spheromycinum appeared.

Treatment of pregnant women with clamidiosis – 3 million ME in 3 times a day 10 days. At treatment of this infection Spheromycinum possesses a bigger therapeutic effectiveness, than Erythromycin.

Analogs Spiramitsin-Vero

Analogs: Rovamycinum, Spiramisar, Spheromycinum Adipate.

Zdravzona

  • Spiramitsin-vero 3 million ME No. 10 tabletkiverofarm joint stock company
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Section: Antibiotics
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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