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In 1 tablet Spheromycinum of 3 million ME. MKTs, poliplasdon, primogel, povidone, magnesium stearate, silicon dioxide, Opadry II as excipients.
In 1 bottle of Spheromycinum adipate of 1,5 million ME.
Tablets, lyophilisate for preparation of solution for in/in uses.
Pharmacodynamics and pharmacokinetics
Spheromycinum — an antibiotic a macrolead. Has bacteriostatic action, bactericidal — in high doses. Reversibly contacting subunit 50S of microorganism ribosomes, suppresses synthesis of protein in a cell. More long-term antibacterial effect, unlike other macroleads, is explained by the fact that it connects to three domains of subunit. In high concentration collects in a bacterial cell.
Are sensitive to drug: Staphylococcusspp., Neisseriameningitidis, Listeriamonocytogenes, Neisseriagonorrhoeae, Corynebacteriumdiphtheriae, Streptococcusspp., Bordetellapertussis, Mycoplasmapneumoniae, Legionellapneumophila, Chlamydiaspp., Clostridiumspp., Treponemaspp., Leptospiraspp., Toxoplasmagondii, Campylobacterspp.
Are steady: Pseudomonas spp., Streptococcus pneumonia, Enterobacteriaceae spp.
Absorption comes from a gastrointestinal tract not completely. After reception of 2 tablets Cmax — 3,3 mkg/ml. Differs low (10%) in linkng with proteins of plasma. Well gets into saliva, lungs, almonds, paranasal sinuses, bones. Does not get through GEB. Gets through a placental barrier — into fruit blood concentration of drug of 50% of concentration in mother's blood. It is metabolized in a liver, its metabolites are active. It is removed mainly with bile and it is insignificant with urine. T1/2 about 8 h after intake of 1 tablet.
Indications to use
- toxoplasmosis (including during pregnancy);
- community-acquired pneumonia (Chlamidia, mycoplasmal and caused by aerobic gram-negative bacteria);
- exacerbation of chronic bronchitis;
- the rheumatism which is not specified;
- acute bronchitis;
- acute tonsillitis, sinusitis, otitis;
- diseases, sexually transmitted;
- skin infections;
- prevention of the meningitis caused meningokokky (at the persons which had contact with patients);
- bacteriocarrier of whooping cough and diphtheria.
- children's age;
- feeding period breast;
- liver failure;
- deficit glyukozo-6-fosfatdegidrogenazy;
- pseudomembranous colitis, nausea, vomiting, ulcer esophagitis, cholestatic hepatitis;
- passing paresthesias;
- thrombocytopenia, acute hemolysis;
- lengthening of an interval of QT;
- Quincke's edema, rash, itch, it is rare — an acute anaphylaxis.
Application instruction Spiramitsin-Vero (Way and dosage)
Is accepted inside. Adults — 2-3 tab. on 3 million ME the day divided into 2-3 receptions. MS dose of 9 million ME.
For the purpose of prevention of the meningitis caused meningokokky take 1 pill (3 million ME) a day within 5 days.
In/in kapelno only adult: contents of a bottle are dissolved in 4 ml of water for injections + 100 ml of 5% of solution of a dextrose.
At pneumonia each 8 h appoint 1,5 million ME.
The application instruction Spiramitsin-Vero contains information that at a renal failure dose adjustment is not carried out.
Cases of overdose are not described. Strengthening of side effects is possible. The antidote does not exist. The symptomatic treatment is recommended.
Spheromycinum with care is appointed together with ergot alkaloids.
At purpose of drug together with a combination the Levodopa + Karbidopa is marked out increase in time of semi-removal of the Levodopa.
Terms of sale
It is released according to the recipe.
It is not higher than 250 Pages.
Period of validity
Use at pregnancy
Spiramitsin-Vero according to indications is applied at pregnancy. Teratogenic effect of drug is not revealed. During a lactation it is contraindicated to apply it as it can be allocated with milk. During this period breastfeeding stops.
Schemes of purpose of Spheromycinum at this disease are various. It is applied in the form of tablets on 3 million ME 3 r / days, in the form of infusions of 3 million ME 3 r / by days in / century. Appointment in the first 2-4 days in the form of infusions, and then orally 7-10 days is possible. And parenteral (in/in) prescription of antibiotics at treatment of pneumonia has no advantages before peroral.
At pyelonephritis at pregnant women drug is appointed on 1.5-3 million ME 3 times a day. At an ureaplazmenny infection at pregnant women also appoint this drug, however data on identification of mycoplasmas and ureplazm resistant to Spheromycinum appeared.
Treatment of pregnant women with clamidiosis – 3 million ME in 3 times a day 10 days. At treatment of this infection Spheromycinum possesses a bigger therapeutic effectiveness, than Erythromycin.
Coincidence on the ATH code of the 4th level:
Analogs: Rovamycinum, Spiramisar, Spheromycinum Adipate.
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