Sulfasalazinum

Сульфасалазин Drug photo

The description is actual on 24.05.2016

  • Latin name: Sulfasalazin
  • ATH code: A07EC01
  • Active ingredient: Sulfasalazinum (Sulfasalazine)
  • Producer: Zhejiang Jiuzhou Pharmaceutical Co. (China), KRKA (Slovenia)

Structure

One tablet with a film cover contains 535 mg of active connection — Sulfasalazinum covered with povidone of 3% with water (in recalculation there correspond 500 mg of Sulfasalazinum).

Prezhelatinizirovanny starch, magnesium stearate and colloid anhydrous silicon dioxide are excipients, and a gipromelloza, propylene glycol — a film cover.

Release form

Sulfasalazinum can be found in a powder form, in plastic bags of various weight, beginning from 50 g. Usually, it is tablets in a film cover, a dosage of 500 mg which are sealed in blisters according to 10 tab. and cardboard boxes, packagings happen on 10 or 50 tablets.

Pharmacological action

Antiinflammatory and antimicrobic.

Pharmacodynamics and pharmacokinetics

Sulfasalazinum — anti-inflammatory drug. Has immunosuppressive action in connecting fabric, in the thickness of an intestinal wall and serous liquid (there is its greatest concentration). Thanks to indestinal flora drug breaks up:

  • to the sulphapyridine suppressing proliferation of cells of T-killers and transformation of lymphocytes;
  • to 5-aminosalicylic acid (Mesalazin) — the most significant connection for treatment of inflammatory diseases of a large intestine. Action mechanism: binding of radicals of free oxygen, local inhibition in an intestinal wall of cyclooxygenase and a lipoxygenase that is necessary for the prevention of formation of prostaglandins, leukotrienes and other mediators of an inflammation.

Pharmacokinetics

About 30% of a dose are absorbed in a wall of a small intestine, other 70% — break up under the influence of indestinal flora of a large intestine. Further active agent gets together with bile into intestines, and also in insignificant quantity is emitted in not changed form with urine. Elimination half-life of 5-10 h.

The released sulphapyridine in a liver is metabolized (on the way of acetylation, a hydroxylation, conjugation together with glucuronic acid), removal happens through kidneys. About 30% of a mesalazin are absorbed and acetylated by a liver, removal — kidneys with urine or in not changed form — with a stake.

Indications to use

Drug is effective for treatment of aggravations and carrying out a maintenance therapy at a stage of remissions:

Contraindications

  • blood diseases;
  • the expressed disturbances of work of a liver or kidneys;
  • porphyria;
  • deficit glyukozo-6-fosfatdegidrogenazy;
  • children are younger than 5 years;
  • III trimester of pregnancy, lactation;
  • superreaction to drug components, streptocides, and also derivatives of salicylic acid.
  • With care appoint at bronchial asthma and risk of allergic reactions.

Side effects of Sulfasalazinum

From following systems, bodies of a human body during therapy undesirable side effects can arise Sulfasalazinum:

  • Peripheral and TsNS: attacks of a headache, dizziness, hallucinations, feeling of a sonitus, ataxy, spasm, various sleep disorders, development of a peripheral neuropathy.
  • Urinary system: disturbances of work of kidneys, intersticial nephrite is possible.
  • Alimentary system: nausea, vomiting, diarrhea, abdominal pains, anorexia, development of hepatitis, pancreatitis.
  • Respiratory system: can become the reason of defeat of pulmonary fabric, an intersticial pneumonitis.
  • System of a hemopoiesis: agranulocytosis, anemia, thrombocytopenia, leukopenia.
  • Reproductive system: infertility, passing phenomenon of an oligospermatism.
  • Allergic reactions: fever, skin rash, the acute anaphylaxis is possible.
  • Among others: yellowness of integuments, contact lenses, urine.

Application instruction of Sulfasalazinum (Way and dosage)

Pill should be taken inside orally, after food.

At ulcer colitis and granulematozny enteritis (illness Krone)

The scheme of treatment of adults and children is more senior than 16: the first daily dose — 2 g divided into 4 receptions, the second — 4 g divided into 4 receptions; the third and all the subsequent — on 6-8 g divided into 4 receptions. When subsiding of acute clinical manifestations of rather supporting daily dose — 1,5-2 g divided into 3–4 receptions is observed. The maintenance therapy can proceed several months, however it is not recommended to children till 16 flyings with body weight to 65 kg.

The maximum daily doses depending on age of patients: adult — 8 g, children — 2 g.

At left-side distal localization of the center it is possible to apply microclysters and candles – 2 times a day to enter into a rectum 1 g of Sulfasalazinum from 1,6 g of cocoa butter.

At a pseudorheumatism, including juvenile

The standard scheme of treatment of adults and children is more senior than 16: on the first week of treatment the recommended daily dose makes 500 mg, on the second — 1000 mg, (divided into 2 receptions), on the third — 1500 mg (divided into 3 receptions).

The therapeutic dose fluctuates within 1,5 — 3 g a day. Achievement of clinical effect requires 6–10 weeks, treatment can last more than 6 months.

The instruction on Sulfasalazinum and a dosage when using in pediatrics:

  • children are 6-8 years old, weighing 20-29 kg — 1 tablet 2 times a day;
  • 8-12 years, the weight of 30-39 kg — 1 tablet to 3 times a day;
  • 12 — 16 years, weight — 40–45 kg — 1 tablet 3 times a day or 2 tablets 2 times a day;
  • since 16 flyings weighing over 50 kg — 2 tablets 2 times a day.

At Bekhterev's illness

When it turns out that treatment of NPVP and hormones – is inefficient, apply Sulfasalazinum as basic drug which is capable to slow down inflammatory process in joints. Accept it it is long – 3-6 months before recreational effect and simplification of a condition of the patient, then – use the maximum doses and begin cancellation of other HP, further reduce a dosage and cancel anti-inflammatory drug.

Sulfasalazinum is not capable to stop pathological process at Bekhterev's illness, however the reached effect can remain few months (NPVP in small doses are necessary) and then therapy resuming is required.

Overdose

Symptomatology

Abdominal pains, nausea, vomiting, dizziness.

Purpose of treatment

Gastric lavage, symptomatic therapy, artificial diuresis.

Interaction

  • The concomitant use of Sulfasalazinum with folic acid and Digoxin reduces the level of their absorption.
  • To anticoagulants and derivatives of a sulfonilmochevina — there is a strengthening of their action.
  • With antibiotics efficiency of active agent of this drug as there is an oppression of indestinal flora decreases.

Terms of sale

In a drugstore it is necessary to show the recipe.

Storage conditions

Temperature indicators should not exceed +25 °C.

It is recommended to store in unavailable to children and domestic animals the place.

Period of validity

No more than five years.

Special instructions

During therapy patients are recommended to use big (3-4 l) amount of liquid.

With alcohol

In spite of the fact that alcohol is not contraindication in drug use, it is considered that Sulfasalazinum and alcohol – are incompatible as there is a risk of damage of a liver, and regular or one-time alcohol intake can lead to faster development of complications.

Analogs where active agent — Salazopyrinum of En and Sulfasalazinum of EN matches. There are generics similar on pharmacological action, but active ingredient is – mesalazin, among them are most known:

  • Asakol;
  • Mesakol;
  • Pentasa;
  • Samezil.

That it is better: Sulfasalazinum or EN?

The main difference EN Sulfasalazinum from Sulfasalazinum is a chemical structure of a film cover of tablets. In EN Sulfasalazinum – the film cover special kishechnorastvorimy that gives the best indicators of bioavailability and absorption of active ingredient, for example, at reception of Sulfasalazinum of EN of 90% of a dose reaches a large intestine, and "simple" – only 70%. However, Sulfasalazinum of EN is made by the American firm Pfayzer and therefore is approximately one third more expensive.

About Sulfasalazinum

Responses of patients – only positive, but in 2015 sharply there was a question of lack of drug in drugstores of the Russian Federation. At forums agree about a possibility of transfer by mail of drug from the closest countries of the former CIS.

About Sulfasalazinum at a pseudorheumatism point out its efficiency and that is important – a possibility of treatment of a juvenile form of a disease. However, a course rather long and some note side reactions in the form of rash, worry into the account of a negative impact for work of a liver and kidneys.

Sulfasalazinum price where to buy

The average price of Sulfasalazinum for packaging of 50 tab. a dosage of 500 mg – 310 rub.

Zdravzona

  • Sulfasalazinum of 500 mg No. 50 tabletkikrka
  • Sulfasalazinum HAN of 500 mg No. 50 tabletkikrka

Drugstore of IFC

  • Sulfasalazinum HAN tbl p / about 500 mg No. 50, KRKA, of. It is new a mestosloveniya
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Apteka24

  • Sulfasalazinkrka (Slovenia)
  • Tablet EN Sulfasalazinum coated 500 mg No. 50KPKA (Slovenia)

Paniapteka

  • Tab. EN Sulfasalazinum p / about 500 mg No. 50KPKA
  • Tab. EN Sulfasalazinum p / about 500 mg No. 50KPKA

BIOSPHERE

  • Sulfasalazinum of 500 mg No. 50 tabl.p.o.
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Section: Gastrointestinal
in more detail

Education: Graduated from the Nikolaev national university of V. A. Sukhomlinsky, gained the diploma of the specialist with honors as "An embryologist, a cytologist, a histologist". Also, the human physiology and animals, the teacher of biology" graduated from a magistracy majoring in ". The course on discipline "Pharmacology" is with honors passable.

Experience: Worked as the senior laboratory assistant of department of Physiology and biochemistry of the Nikolaev national university of V. A. Sukhomlinsky in 2010 - 2011.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Sulfasalazinum surely consult with the attending physician.
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