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Drug Sulperazon is let out in the form of powder on 2 g, in bottles No. 1.
Pharmacodynamics and pharmacokinetics
Sulperazon – the combined antibiotic drug where inhibitor β-лактамаз – to sulbakta protects also supplements generation cephalosporin III influence – a tsefoperazon.
Thanks to the ability to suppression in a cell wall of bacteria of biosynthesis of a mukopeptid, tsefoperazon interferes with a reproduction of microorganisms in a phase of their active reproduction.
Sulbaktam, though in itself not possessing clinically significant antibacterial influence, except for Acinetobacter and Neisseriaceae, is inhibitor (irreversible) of the most part of the main β-лактамаз, developed by bacteria and showing resistance to a beta laktamnym to antibiotics.
The combination of these two medicines, in relation to bacteria moderately sensitive to effects of a tsefoperazon, much more exceeds efficiency of the last at its use in monotherapy.
At parenteral administration of Sulperazon of T1/2 of a tsefoperazon it is equal 1,7 hour, and a sulbaktama to about 60 minutes. Removal of a tsefoperazon for 25% it is carried out with urine and for 75% with bile.
Sulbaktam is generally brought by kidneys. Both active ingredients of drug in an organism do not kumulirut.
At serious pathologies of kidneys (KK less than 30 ml/min.) need of correction of doses of Sulperazon, because of directly proportional ratio of clearance of a sulbaktam to clearance of creatinine exists.
Indications to use
The diseases of an infectious and inflammatory etiology caused by microorganisms, sensitive to a complex of active ingredients of drug:
- respiratory infections;
- intraabdominal infections (including a cholangitis, cholecystitis, peritonitis);
- infections of urinary tract;
- infections of joints and bones;
- infections of soft tissues and integuments;
- painful conditions of bodies of a small pelvis of an inflammatory origin (including an endometritis).
Hypersensitivity to a tsefoperazon, a sulbaktam, and also penicillin or cephalosporins.
System of a hemopoiesis and cardiovascular system:
- lowering of a hemoglobin content and hematocrit;
- change of duration of coagulability of blood;
- arterial hypertension.
Bodies gastrointestinal tract and liver:
- disturbance of a chair;
- pseudomembranous colitis;
- activation of liver enzymes;
- diarrhea (it is possible because of influence of Clostridium difficile what demands purpose of adequate treatment).
- makulopapulezny rash;
- itch of integuments;
- Stephens-Johnson's syndrome;
- small tortoiseshell;
- acute anaphylaxis.
- positive test of Koombs;
- development of phlebitis (at in introduction);
- morbidity (at in oil and in injections).
Application instruction of Sulperazon
The application instruction of Sulperazon in the form of powder, assumes its use for preparation of injection solution which depending on indications and recommendations of the doctor, it is possible to enter in oil, in/in and infusionally.
Before the first administration of drug test for portability is obligatory. In independence of a way, all introductions has to carry out the qualified medical personnel.
For injections in oil it is necessary to dissolve powder in water for infection then it is possible to add 2% Lidocaine solution, having preposted its portability test.
For in/in introductions powder can be dissolved in the appropriate volume of water for infection, 5% solution of glucose or solution of sodium chloride.
Infusions with Sulperazon, carry usually out for 15-60 minutes. Jet in/in introduction takes on average 3 minutes.
The dosage, the mode of introduction and duration of treatment have to correspond to the diagnosed disease and are defined by the doctor.
The adult dosage, as a rule, equals 1-2 g (0,5-1 bottle) with frequency at 12 o'clock and a possibility of its increase, at a severe disease, to 4 g (2 bottles) with the same interval of introduction. This dosage (4 g of Sulperazon) is greatest possible. At pathologies of kidneys and a liver, the maximum dosage should not exceed 2 g (1 bottle).
At disturbance of renal function with KK of 15-30 ml/min., the daily dosage has to be no more than 2 g (one bottle), at KK it is less than 15 ml/min. – 1 g (0,5 bottles), when passing a hemodialysis Sulperazon's introduction should be carried out depending on his sessions (according to the recommendation of the nephrologist).
The children's dosage usually decides by a ratio of 10 mg/kg, on frequency of introduction of 6, 8 or 12 hours. In the first week after the birth the interval between introductions has to be not less than 12 hours. The most admissible daily children's dosage equals 80 mg/kg and is applied exclusively in case of need at treatment of extremely heavy infections.
At overdose by Sulperazon development of side negative effects or their strengthening is possible. Also, high content in cerebrospinal liquid beta laktamnykh antibiotics can cause neurologic disturbances, including spasms.
The symptomatic treatment with a possibility of carrying out a hemodialysis which in particular is effective at patients with pathologies of kidneys is shown.
In case of need Sulperazon's appointments the patient needing artificial nutrition (parenterally or inside), it is necessary to refuse use of etanolsoderzhashchy solutions.
Sulperazon's solutions and aminoglycosides pharmaceutical are incompatible therefore their direct mixing is inadmissible.
In case of need such combination of HP, it is necessary to enter them consistently using individual secondary catheters, obligatory washing of primary catheter and with as it is possible big intervals.
Terms of sale
Medicine Sulperazon is sold according to the recipe.
Bottles with powder can be stored at a temperature up to 25 °C.
Period of validity
The closed bottles are stored for 24 months.
At the patients using beta laktamnye antibiotics episodes of reactions of hypersensitivity of serious character were noted (anaphylactic) and even cases of a lethal outcome are recorded. The risk of development of these reactions is much higher at patients in whose anamnesis cases of manifestations of hypersensitivity are noted.
In case of suspicion on allergic reactions of such character it is necessary to cancel right there Sulperazon's introduction and to appoint the corresponding treatment. At serious anaphylactic manifestations in/in enter Epinephrinum (adrenaline), glucocorticoids, and also watch passability of ways of breath.
Heavy obstruction of zhelchevyvodyashchy ways, serious pathologists of a liver, and also functional disturbances of kidneys can be required corrections of doses and the mode of introduction.
At parallel disturbance of functions of kidneys and a liver it is necessary to monitor the serumal maintenance of a tsefoperazon and, in case of need to modify its dose in time. At impossibility of carrying out such control, the daily dose of a tsefoperazon should not be higher than 2 g (2 bottles).
In rare instances, at therapy by Sulperazon, observed insufficiency of vitamin K, it is probable because of oppression of the intestinal microflora producing this vitamin.
Risk group of forming of deficit of vitamin K are patients with malabsorption, defective or artificial nutrition, and also the sick receiving anticoagulants. In such cases it is necessary to watch a prothrombin time and at need to appoint vitamin K.
Long therapy by Sulperazon can lead to the excess growth of microorganisms, insensitive to its ingredients, that demands careful supervision during therapy.
At long-term use of Sulperazon systems of a hemopoiesis, in particular at newborns and children recommend to watch periodically indicators of functionality of internals also.
Coincidence on the ATH code of the 4th level:
- Medical axon;
- Fortum, etc.
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