Teralidzhen

Тералиджен Drug photo

The description is actual on 22.05.2014

  • Latin name: Teraligen
  • ATH code: R06AD01
  • Active ingredient: Alimemazina Tartrat (Alimemazine Tartrate)
  • Producer: Pharmaceutical Joint-stock Company of Hauzyang, Vietnam

Structure

5 mg of an alimemazin of tartrate are a part of 1 tablet. In addition in structure there are following auxiliary ingredients: silicon dioxide colloid, lactose (sugar milk), talc, starch wheat, magnesium stearate, sucrose (the sugar refined), tapioca.

Structure of a cover: talc, titanium dioxide, gipromelloz, dye pink, macrogoal 6000.

Release form

Medicine is issued in the form of tablets of dark pink color, coated film. On the one hand there is a strip, with another – the squeezed-out symbol.

Medicine in planimetric packagings is sold, in each packaging there are 10 or 25 tablets, in a cardboard pack there can be 1, 2, 5 packagings.

Pharmacological action

Tablets Teralidzhen render spasmolytic, antiemetic, antihistaminic, somnolent, antibechic and antipsychotic action.

Pharmacodynamics and pharmacokinetics

Teralidzhen is a neuroleptic (antipsychotic means) having serotoninblokiruyushchy, spasmolytic and antihistaminic effect, and also somnolent, antiemetic, antibechic and sedative action.

It is possible to observe effect after reception in 10-15 minutes, duration of its action makes from 6 to 8 hours.

At drug low antipsychotic activity therefore it is ineffective at an acute stage of psychotic states.

It is applied also to therapy of elderly people, also children and teenagers as drug possesses good tolerance.

It is soaked up completely, quickly, it is possible to observe the maximum concentration in plasma after reception in 1-2 hours. Within 2 days it is removed in the form of a metabolite by kidneys (70-80%).

Indications to use

This medicine is applied to treatment of the following diseases:

  • sleep disorders;
  • senestopathetic depressions;
  • at somatopathies condition of alarm and nervousness;
  • psychopathies with psychoasthenic and asthenic frustration;
  • the somatized mental disorders;
  • neurosises and neurosis-like conditions of organic or endogenous genesis with hypochiondrial, psychovegetative, senestopathetic and phobic frustration;
  • allergic reactions;
  • alarming and depressive diseases (at vascular and boundary diseases).

Contraindications

Teralidzhen has a number of contraindications:

Administration of drug it is appointed with care in the following cases: oppression of function of marrow, epilepsy, arterial hypotension, alcoholism, jaundice, predisposition to an ischuria, open angle glaucoma, obstruction of a neck of a bladder.

Side effects

Tablets Teralidzhen possess good tolerance and seldom cause emergence of side effects.

The following side effects are possible:

  • tachycardia, pressure decrease, dizziness;
  • accommodation paresis, ring, sonitus;
  • the increased viscosity of a bronchial secret, dryness in a throat, a nose;
  • slackness, drowsiness, fast fatigue (these symptoms usually arise in the first days, drug withdrawals do not demand), nightmares, concern, irritability, excitement; in rare instances the hypokinesia, confusion of consciousness, a tremor, an akathisia can be observed, children have an increased convulsive activity;
  • ischuria, bladder atony;
  • loss of appetite, lock, gastrointestinal tract atony, dryness in a mouth;
  • muscular relaxation, oppressions of a hemopoiesis in marrow, a photosensitization, allergic reactions, the increased sweating.

Application instruction of Teralidzhen (Way and dosage)

Tablets are intended for intake.

For receiving somnolent effect in days adults need to accept 5-10 mg, anksiolitichesky effect – 60-80 mg, at a psychotic state – 0,2-0,4 g.

The instruction on Tiralidzhen for children (7 years are more senior): for achievement of somnolent effect – 2,5-5 mg, anksiolitichesky effect – 20-40 mg, at treatment of allergic reactions – 5-20 mg. The daily dose at a psychotic state can be increased to 60 mg.

The daily dose should be distributed on 3-4 receptions.

Overdose

At overdose oppression of consciousness, and also strengthened action of side effects is observed.

As there is no special antidote, the symptomatic treatment is applied. In an hour after reception of a high dose of Teralidzhen it is necessary to wash out a stomach and to appoint enterosorbentny means (to reduce absorption of an alimemazin).

Interaction

Drug can strengthen effect of anksiolitichesky, somnolent, antipsychotic means, narcological analgetics, means of the general anesthesia, hypotensive drugs and m-holinoblokatorov. In such cases it is necessary to adjust a dose.

Teralidzhen reduces effectiveness of m-holinostimulyatorov, a dopamine, ephedrine, amphetamine, a levodopa, guanetidin. Considerable oppression of TsNS is observed at a concomitant use with drugs which suppress the TsNS functions and ethanol. The combination to barbiturates and antiepileptic means leads to reduction of the threshold of convulsive readiness.

Increase of concentration in plasma of an alimemazin is caused by beta adrenoblockers that can lead to development of arrhythmia and pressure decrease.

Teralidzhen promotes increase of level of prolactin in blood and reduces efficiency of Bromocriptinum.

M-holinoblokiruyushchaya activity of an alimemazin amplifies during reception of antikholinegichesky means and tricyclic antidepressants.

The risk of emergence of extrapyramidal frustration and arterial hypotension increases at reception of MAO inhibitors and derivatives of a fenotiazin.

Terms of sale

It is possible to get Teralidzhen in a drugstore strictly according to the recipe.

Storage conditions

It is necessary to store tablets in the dark place at a temperature no more than 25 °C.

Period of validity

It is necessary to store drug 3 years.

Special instructions

In cases when it is necessary long therapy, it is necessary to estimate function of a liver and to constantly carry out blood test.

At administration of drug the need for Riboflavinum increases.

During therapy the test for pregnancy can yield a positive take.

During reception drug it is not necessary to take the wheel of the car or to be engaged in the work demanding fast reaction and concentration.

Teralidzhen's analogs

Coincidence on the ATH code of the 4th level:

The following analogs of this drug are at the moment known: Rispolept, Serokvel, Alimemazina Tartrat.

Zdravzona

  • Teralidzhen of 5 mg No. 50 of a tabletkivalent Pharmaceutics of joint stock company
  • Teralidzhen of 5 mg No. 25 of a tabletkivalent Pharmaceutics of joint stock company

Drugstore of IFC

  • Teralidzhen tbl p / about 5 mg No. 50, Hau Giang Pharm.Vyetnam
  • Teralidzhen tbl p / about 5 mg No. 25, Hau Giang Pharm.Vyetnam
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Section: For a nervous system
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