Tevakomb

Тевакомб Drug photo

The description is actual on 18.08.2015

  • Latin name: Tevacomb
  • ATH code: R03AK06
  • Active ingredient: Salmeterol * + Flutikazon *
  • Producer: Tsipla Ltd., India

Structure

Ksinafoat of a salmeterol of 0,025 mg and propionate of a flutikazon of 0,050, 0,125 or 0,250 mg.

Ethanol, tetraftoretan, lecithin — as excipients.

Release form

The dosed aerosol for inhalations in an aluminum cylinder.

Pharmacological action

Bronkhodilatiruyushchy and antiinflammatory (combination of the selection beta of a 2-adrenomimetik + glucocorticosteroid).

Pharmacokinetics and pharmacodynamics

Pharmacodynamics

The combined medicine with two active components: flutikazon (synthetic glucocorticosteroid) and salmeterol (the selection beta 2-adrenomimetik).

Flutikazon possesses antiinflammatory and antiallergic action, interacting with glucocorticoid receptors of respiratory tracts. It reduces products of mediators of an inflammation and other active agents (leukotrienes, a histamine, cytokines and prostaglandins) participating in forming of an allergic sensitization. At its influence permeability of capillaries decreases, slime secretion decreases, exudation is suppressed and it is recovered prokhodimos bronchial tubes.

Salmeterol increases the maintenance of tsAMF in a cell that leads to relaxation of smooth muscles of bronchial tubes. Provides a long bronkhodilatation (not less than 12 h) and prevents emergence of a bronchospasm, increases ZhEL. Salbutamol possesses bigger selectivity to a beta to 2 adrenoceptors, than. Does not influence cardiovascular system.

Pharmacokinetics

Absorption of a flutikazon happens through lungs. The part of an inhalation dose is swallowed, but owing to bad solubility bioavailability makes no more than 1% of a gastrointestinal tract. The maximum concentration in blood is defined in 0,35-1,5 hours. There is a dependence between the size of a dose and its concentration in blood. For 91% contacts proteins of plasma. It Biotransformirutsya in a liver with the assistance of system of P450 cytochrome and an isoenzyme of CYP3A4 therefore the inactive metabolite is formed. The final elimination half-life is removed 5,9 hours by intestines and kidneys.

Salmeterol is absorbed by lungs and gets to a system blood stream, without being exposed to a metabolism. The maximum concentration in blood is defined in 5-10 minutes. Concentration also correlates with a dose.

Indications to use

Contraindications

  • hypersensitivity;
  • age till 4 years.

At tuberculosis, viral and fungal infections, a thyrotoxicosis, a diabetes mellitus, hypopotassemia, arterial hypertension, arrhythmia, osteoporosis, a cataract, glaucoma, pregnancy drug is appointed with care.

Side effects

  • tachycardia, disturbances of a cordial rhythm, myocardium ischemia;
  • headaches, frustration of a dream, hyperreactivity, uneasiness, irritability, tremor;
  • rash, Quincke's edema, allergic rhinitis, asthma and bronchospasm;
  • bleedings from a nose, a nose congestion, hoarseness of a voice, dryness mucous, laryngitis;
  • change of flavoring feelings, reduction of salivation, abdominal pain, gas generation, hemorrhoids, locks;
  • eczema, hemorrhages, dermatitis and dermatosis;
  • joint pains, spasms in muscles;
  • candidiasis of a mucous oral cavity, infection of urinary tract.

At use of drug development of a bronchospasm is possible — drug is cancelled.

Tevakomb, application instruction (Way and dosage)

At bronchial asthma to adults and children since 12 all forms of release with different doses appoint 2 doses 2 times a day. To children of 4 — 12 years Tevakomb of 25 mkg / 50 mkg — 2 doses is appointed twice.

At HOBL apply Tevakomb of 25/250 mkg and 25/125 mkg on 2 doses twice.

At achievement of clinical effect the dose is reduced to minimum effective — pass to a smaller dosage and reduce frequency rate of use. For receiving effect drug is used even in the absence of disease symptoms.

Dose adjustment at patients of advanced age and at pathology of a liver or kidneys is not carried out.

Overdose

At overdose the tremor, tachycardia and a headache appear.

Treatment: use of antidotes (cardioselective beta-blockers). They are appointed with care at patients with a bronchospasm. If treatment by drug is cancelled, then appoint replacement therapy of GKS.

At use of high doses the long time is possible oppression of bark of adrenal glands.

Interaction

Interaction with other inhibitors of an isoenzyme CYP3A4 is possible. It is impossible to appoint at the same time the selection beta adrenoblockers and non-selective at patients with bronchial asthma (risk of development of a bronchospasm).

Simultaneous use of other agonists the beta of 2 adrenoceptors attracts strengthening of effects.

Terms of sale

According to the recipe.

Storage conditions

At a temperature up to 30 °C.

Period of validity

3 years.

Analogs

Coincidence on the ATH code of the 4th level:

Seretid.

About Tevakombe

Tevakomb Seretid is generic of original drug. At cost it is 2,5-3 times cheaper, but there is a prejudice "more expensively — means better". According to results of clinical trials, between these drugs there is no distinction in bioavailability and efficiency. However, patients sometimes note some discomfort, concern and fear upon transition from one drug to another which are connected with change of a form, the size and color of a barrel of an inhaler. Even these psychological aspects at patients with bronchial asthma can lead to destabilization of a state, development of side effects. Are explained by it sometimes meeting negative About efficiency of drug. Often sick it is difficult to break a barrier and to develop the positive relation to generic or new drug.

Parents of children, the suffering patients with bronchial asthma, claim that the difference by efficiency is not noticed and often pass from one drug to another.

Zdravzona

  • Tevakomb aerosol of 25 mkg +250mkg/dose 120 doses No. 1 ballonchikteva Pharmaceutical
  • Tevakomb aerosol of 25 mkg +125mkg/dose 120 doses No. 1 ballonchikteva Pharmaceutical
  • Tevakomb aerosol of 25 mkg +50mkg/dose 120 doses No. 1 ballonchikteva Pharmaceutical
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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