Тиорил Drug photo

The description is actual on 25.07.2016

  • Latin name: Thioril
  • ATH code: N05AC02
  • Active ingredient: Thioridazine (Thioridazine)
  • Producer: Torrent Pharmaceuticals (India)


In 1 tablet of thioridazine of 25 mg. Calcium hydrophosphate, starch, magnesium stearate, PVP K-30, talc as excipients.

Release form

Tablets in a cover of 25 mg.

Pharmacological action

Sedative, antipsychotic.

Pharmacodynamics and pharmacokinetics


Active ingredient is derivative a fenotiazina. Oppresses dofaminergichesky and adrenergic transfer. Reduces activity of a vegetative nervous system. In small doses shows anksiolitichesky action, at the same time intensity and alarm decreases. Oppresses psychomotor functions therefore it is effective at superexcitation, the affective tension, hypermotility and agitation. The antipsychotic effect is combined with sedative without development of block, slackness and emotional indifference. Antiemetic action is expressed poorly, sedative — is moderate, extrapyramidal and kataleptogenny — is minimum. Renders hypotensive (different degree) and moderate antidepressive action.


At intake it is completely soaked up in a gastrointestinal tractCmax in blood is defined by 1–4 h by Biotransformiruyetsya in a liver with the participation of CYP2D6, active metabolites are as a result formed. T1/2 is from 6 to 40 hours old. It is removed by kidneys. The metabolite mezoridazin is more active, has бóльший an elimination half-life.

Indications to use

  • neurosises with persuasive states, fear, agitation, tension;
  • maniac-depressive psychosis;
  • psychomotor excitement;
  • schizophrenia;
  • tics;
  • abstinence syndrome at alcoholism and toxicomanias.


  • heart failure in a decompensation stage;
  • the expressed arterial hypertension or hypotension;
  • hypersensitivity;
  • arrhythmia;
  • comas;
  • CHMT;
  • pregnancy;
  • feeding by a breast;
  • age (till 2 flyings);
  • porphyria;
  • reception with the drugs extending QT.

With care it is appointed at hemopoiesis disturbance, alcoholism with hepatotoxic manifestations, at a breast cancer, glaucoma, a hyperplasia of a prostate, a peptic ulcer, tendency to tromboembolic episodes, epilepsy, a syndrome to Reja.

Side effects

  • drowsiness (at reception of high doses);
  • unconscious states;
  • late dyskinesia, excitement;
  • confusion of consciousness, hallucination, sleep disorder;
  • extrapyramidal disturbances;
  • decrease in a convulsive threshold;
  • vision disorder;
  • hypoptyalism, appetite decrease/increase, nausea, vomiting, cholestatic hepatitis;
  • lock/diarrhea;
  • amenorrhea, dysmenorrhea, gynecomastia;
  • increase in weight;
  • decrease in the ABP, ventricular disturbances of a rhythm, tachycardia;
  • bronchospasm;
  • dysuria, ischuria;
  • skin rash, Quincke's disease;
  • peripheral hypostases.

Thioryl, application instruction (Way and dosage)

Drug is accepted inside. The dose for adults and children since 12 varies with the broad range — from 25 mg to 600 mg a day (the maximum 800 mg) that depends on a disease and expressiveness of symptoms. Frequency rate of use of drug from one to four times a day. Treatments high doses spend no more than a month. To children of 5 years drug is appointed by 75 mg the day divided into 2-4 receptions.


Overdose is shown by drowsiness, orientation disturbance, confusion of consciousness, an ischuria, an areflexia, dryness in a mouth, hypotension, spasms and oppression of a respiratory center. The specific antidote does not exist. Symptomatic therapy is carried out.


Active agent strengthens action of somnolent, narcotic and analgeziruyushchy means, weakens action of a levodopa. The action synergism with the general anesthetics is noted. Atropine strengthens anticholinergic action, and antidiabetic drugs increase risk of abnormal liver functions. Reduces efficiency of action of Apomorphinum. Increases concentration of prolactin.

Reduces effect of antiepileptic drugs. At a combination to beta adrenoblockers hypotensive action amplifies. Probucol, astemizol, Disopyramidum, tsizaprid, Pimozidum, procaineamide, quinidine and erythromycin promote lengthening of an interval of QT. Aritmogenny action amplifies at a concomitant use of adrenostimulyator. Ephedrine causes paradoxical decrease in the ABP.

At use with antidepressants,  MAO inhibitors, Maprotilinum, antihistaminic drugs strengthening of sedation and strengthening of a hyponatremia at reception of thiazide diuretics is noted. Strengthening of extrapyramidal disturbances is noticed at co-administration of drugs of lithium. The risk of a miyelosupressiya at joint administration of drugs increases, oppressing a hemopoiesis.

Terms of sale

It is released according to the recipe.

Storage conditions

Temperature is up to 30 °C.

Period of validity

3 years.

Analogs of Thioryl

Coincidence on the ATH code of the 4th level:

Tiodazin, Sonapaks, Thioridazine, Ridazin, Tison, Melleril.

About Thioryl

Drugs on the basis of thioridazine are used more than 50 years in psychiatric practice. It is close to is close on pharmacological action to other fenotiazinovy derivatives, but feature is lack of extrapyramidal frustration at its reception. It is a "average" neuroleptic with weak antipsychotic action and moderate sedative. If to compare to aminazine and Tisercinum antipsychotic action is weaker. The tablets Thioryl the most part are appointed at a condition of alarm, intensity and fear which are combined with phobias, morbid depression and persistence. Important the fact that it does not cause block — just has the calming effect.

It is mainly appointed to patients with somatoformny vegetative dysfunction (existence of numerous complaints in the absence of objective confirmations of a disease), at alarming frustration, and to children at alarm, motive concern, fears, existence of tics.

  • "… Appointed this drug when I had an alarm. Saws on 1/2 tablets 3 times month. Helped well".
  • "… At panic attacks and alarm Thioryl helped me".
  • "… Thioryl helps me even better, than antidepressants — cleans alarm, improves a dream, I quietly react to everything".
  • "… A saw the whole year at neurosis. It was pleasant to me — concerns nothing, everything is good. Only tachycardia from it 100".
  • "… Helps me a dose of 25 mg for the night — cleans alarm and improves a dream what antidepressants did not cope with".
  • "… Personally did not help me — the dream did not improve, did not remove alarm. Sharply lowers pressure".


  • Thioryl 25 of mg No. 100tab
to show still


  • Tab. thioryl p / about 25мг№30
Section: For a nervous system
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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