Thyreocombum

Тиреокомб Drug photo

The description is actual on 30.06.2016

  • Latin name: Thyreocomb
  • ATH code: H03AA03
  • Active ingredient: Sodium left thyroxine + Liothyroninum + Potassium iodide (Levothyroxine sodium + Liothyronine + Potassium chloride)
  • Producer: Berlin-Chemie AG, Menarini Group Glienicker (Germany)

Structure

Left thyroxine, liothyroninum, potassium iodide, monohydrate of lactose, corn starch, magnesium stearate, methylparahydroxybenzoate gelatin, silicon dioxide colloid, propilparagidroksibenzoat, sodium hydroxide, glycerin, talc.

Release form

Tablets of a round, ploskotsilindrichesky form of white color, in the blister No. 25 or in bottles No. 40 in a cardboard box.

Pharmacological action

Thyroid.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The drug containing synthetic hormones of liothyroninum and the left thyroxines which are a part of hormones of a thyroid gland and potassium of iodide, the being structural element in the course of synthesis of thyroxine and triiodothyronine. A basic purpose — completion of a lack of an organism of hormones of a thyroid gland.

Thyreocombum stimulates their growth and a differentiation of fabrics, increases their oxygen requirement, increases the level of the main metabolism. In high doses renders catabolic effect, in insignificant — anabolic effect. Suppresses synthesis of thyritropic hormone. Increases power processes, positively influences cardiovascular and nervous systems, functions of kidneys and a liver.

Pharmacokinetics

Left thyroxine at intake is soaked up in an upper part of a small intestine (to 80% of the accepted dose). The maximum concentration in blood comes in 6 hours. About 99% of drug contact blood proteins. The therapeutic effect is shown for 3-6 day after the beginning of reception.

Levotiroksin in a liver, muscles, kidneys, brain tissues is metabolized. Metabolites are pharmacological not active, are removed with urine and bile. A left thyroxine elimination half-life — one week.

Liothyroninum is also mainly soaked up in a small bowel (78-95% of a dose). The maximum concentration in blood comes for 2-3 day. In 7-9 days after the end of reception drug is terminated. During pregnancy increase in the connecting ability with blood proteins is observed. at a hypoproteinemia ability to binding decreases. It is metabolized in a liver, muscles, brain tissues, kidneys. The elimination half-life of liothyroninum makes one days.
Inorganic iodine is almost completely soaked up in a small bowel. It is removed with urine.

Indications to use

Contraindications

High sensitivity to drug, a myocardial infarction, a thyrotoxicosis, myocarditis, stenocardia at patients is more senior than 60 years, functional disturbances in bark of adrenal glands.

Side effects

Are shown by thyrotoxicosis symptoms (tachycardia, a tremor, sleeplessness, stenocardia, arrhythmias, decrease in body weight, diarrhea, uneasiness) and allergic reactions.

Thyreocombum, application instruction (Way and dosage)

The dose of drug is individual and is selected the doctor taking into account clinic and data of laboratory inspection. All daily dose should be accepted once, in the morning, in 30-45 min. prior to a breakfast, not to chew, wash down a tablet with water. Administration of drug has to be regular. As a rule, begin with a dose 1/2 tablets of drug a day. Depending on requirement, it is possible to increase an initial dose to the level of a maintenance dose (1-2 tablets) each 1-2 weeks.

To the patients of advanced age having cardiovascular diseases, having epilepsy and the patient with insufficiency of bark of adrenal glands, the period of selection of an effective dose of Thyreocombum, and adaptation to it it is necessary to increase to 1-1,5 months and more. Duration of administration of drug is defined for each patient separately. It is forbidden to change a dose or to stop treatment independently.

Overdose

In cases at too fast increase in an initial dose at the beginning of therapy thyrotoxicosis symptoms can be observed: heartbeat, disturbance of a cordial rhythm, a tremor of fingers, internal concern, sleeplessness, the increased perspiration, decrease in body weight, diarrhea.

Interaction

Thyreocombum increases efficiency of indirect anticoagulants that can demand correction of their dose. At a concomitant use of drug with Phenytoinum, dikumaroly, Clofibratum, salicylates or furosemide in a dosage higher than 250 mg action of Thyreocombum amplifies. Reception of tricyclic antidepressants together with Thyreocombum can increase efficiency of antidepressants.

At a concomitant use of Thyreocombum with kaliysberegayushchy diuretics can potassium level in blood will increase. Effect of cardiac glycosides at reception of Thyreocombum decreases. At a concomitant use with anabolic steroids, Tamoxifenum pharmacokinetic interaction of drugs at the level of protein-binding can take place.

Reception of carbamazepine, rifampicin and phenobarbital increases clearance of left thyroxine and there can be a requirement of increase in a dose of Thyreocombum. Drug at simultaneous use with Somatropin, accelerates process of closing of epiphyseal regions of growth.

Terms of sale

According to the recipe.

Storage conditions

At a temperature not above 25 °C.

Period of validity

3 years.

Analogs of Thyreocombum

Coincidence on the ATH code of the 4th level:

L-thyroxine, Novotiral, Eutiroks, Bagotiroks, Tireoty.

About Thyreocombum

Thyroid hormones raise standard metabolism, stimulate disintegration of fats, proteins and carbohydrates. This action is the cornerstone of use of hormones for weight loss. In this regard also Thyreocombum is quite often applied to weight loss. Responses, questions and reasonings at the forums devoted to this subject testify to it.

It has justification if drug is appointed by the doctor after research of level of hormones. At their insufficient products and a clinical picture of a hypothyroidism of different severity for the purpose of replacement therapy reception of this drug is shown. The specialist appoints drug in doses which are necessary for compensation of this state.

And it is absolutely unreasonable and just dangerous to accept hormones independently to accelerate weight reduction process. Uncontrolled reception of hormones leads to heavy endocrine disturbances – to a hyperthyroidism from the thyrotoxicosis phenomenon: tachycardia, excitement and sleeplessness. Considering that drug contains potassium iodide, and in it there is no requirement of an organism, it will depress secretion of thyritropic hormone. It turns out that it is method of controlling hazardous to health with extra kilos.

As for use of this drug at a hypothyroidism. The combined drugs which contain synthetic hormones (Thyreocombum, Tireotom, Novotiral) are practically not applied now by endocrinologists. They were succeeded by monopreparta drugs with L-thyroxine T4 absolutely identical to natural hormone of the person — Eutiroks and L-thyroxine who provide maintenance of level of the general thyroxine in an organism.

The combined drugs except left thyroxine (analog of T4) contain liothyroninum (analog of T3) which reception creates peaks of concentration in blood, renders negative effects on an organism. Peaks of concentration are less desirable for an organism, than their absence. In the combined drugs the ratio of hormones not physiological, advantages of the combined drugs before monotherapy is not revealed, and they were forced out by monodrugs for treatment of a hypothyroidism. Absence in pharmacy chain of Thyreocombum, Tireotoma and others since 2011 is explained by it.

Zdravzona

  • Tablet Thyreocombum No. 40
to show still
Section: Hormonal
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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