Tireotom

Тиреотом Drug photo

The description is actual on 20.07.2016

  • Latin name: Thyreotom
  • ATH code: H03AA03
  • Active ingredient: Sodium left thyroxine + Liothyroninum (Levothyroxine sodium + Liothyronine)
  • Producer: Berlin-Chemie AG/Menarini Group (Germany)

Structure

Sodium left thyroxine, liothyroninum, lactoses monohydrate, silicon dioxide, corn starch, gelatin high-disperse, glycerin, magnesium stearate.

Release form

Tablets of a round form ploskotsilindrichesky, white color, in glass bottles No. 60 in a cardboard pack or in the blister in a cardboard pack No. 50, 100.

Pharmacological action

Compensating for the deficiency of hormones of a thyroid gland.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The drug used in replacement therapy of a lack of hormones of a thyroid gland. Increases need of fabrics for supply with oxygen, stimulates fabric growth and a differentiation, improves processes of a metabolism, activates a lipometabolism, suppresses production of thyritropic hormone. Stimulates power processes, positively influences functions of a liver, kidneys, cardiovascular and nervous systems.

Pharmacokinetics

At reception of left thyroxine of nearly 80% of a dose it is soaked up in thin department of intestines. The food slows down absorption process. After intake the maximum concentration of Levotiroksin in blood is noted in 5-6 hours. About 99% of a dose of drug contact blood proteins (albumine, globulin). In body tissues process of monodeiodinating with formation of triiodothyronine and others pharmacological inactive products is carried out. The metabolism of thyroid hormones occurs in a liver, a brain kidneys and in muscular tissue. An elimination half-life — 6-7 days. Metabolites are removed with bile and urine.

Absorption of a lioteranin at intake makes about 95%. Communication with blood proteins — high. The elimination half-life — is removed 3 days with urine.

Indications to use

  • In therapy of a hypothyroidism, a diffusion toxic craw, euthyroid craw; in a post-operational cancer therapy of a thyroid gland;
  • In replacement therapy and prevention of recurrence of a craw in the postoperative period after a resection of a thyroid gland.

Contraindications

High sensitivity to drug, acute myocarditis, stenocardia of the III-IV degree, a myocardial infarction, a thyrotoxicosis, insufficiency of adrenal glands.

To take with caution at an ischemic heart disease, heart failure, tachycardia, arterial hypertension, a diabetes mellitus, atherosclerosis, to patients of advanced age.

Side effects

In rare instances allergic reactions, progressing of stenocardia, development of heart failure.

Tireotom, application instruction (Way and dosage)

To accept once, without chewing, in 30-60 minutes prior to a breakfast, washing down with water. The daily dose depends on a look and disease severity:

  • Hypothyroidism. An initial dose for adults: 1 tablet a day, increase at 1 tablet every 2-4 week to a dose of 2-5 tablets. For children the recommended average maintenance dose is equal 2-2,5 tablets a day.
  • Euthyroid craw. An initial dose for adults: — 1-2 tablets a day, supporting — 3-6 tablets. For children the daily dose makes 0,5-1 tablet a day.
  • After operational removal of cancer of thyroid gland: 3 tablets a day as an initial dose and 6 tablets — as a maintenance dose.
  • Postoperative prevention of development of a craw: 2-3 tablets a day.

Duration of reception depends on a type of a disease. Most often prolonged treatment, of several months before lifelong administration of drug.

Overdose

It is shown by the symptomatology characteristic of a thyrotoxicosis — heartaches, heartbeat, concern, the increased perspiration, disturbance of a heart rhythm, a tremor, a sleep disorder, a body degrowth, appetite increase, diarrhea.

Interaction

Drug increases efficiency of indirect anticoagulants and reduces efficiency of cardiac glycosides. Tireotom's use with tricyclic antidepressants strengthens effects of antidepressants. At a concomitant use with salicylates, furosemide, Phenytoinum and Clofibratum in doses over 250 mg are noted increase of content of hormones of a thyroid gland, untied with blood proteins. Tireotom accelerates process of closing of epiphyseal regions of growth.

Terms of sale

Prescription issue.

Storage conditions

At a temperature of 15-25 °C.

Period of validity

3 years.

Tireotom's analogs

Coincidence on the ATH code of the 4th level:

Novotiral, L-thyroxine, Bagotiroks, Levotiroksin, Yodtiroks, Thyreocombum, Eutiroks.

About Tireotom

About drug in most cases positive, some patients note that drug Tireotom causes emergence of side effects in the form of sweating, drowsiness, fatigue, irritability and loss of weight.

Section: Hormonal
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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