Tizalud

Тизалуд Drug photo

The description is actual on 27.11.2014

  • Latin name: Tisalud
  • ATH code: M03BX02
  • Active ingredient: Tizanidin (Tizanidine)
  • Producer: JSC Verofarm (Russia)

Structure

One tablet includes: 2 mg or 4 mg of Tizanidin — active ingredient.

Additional substances: sodium carboxymethylstarch, lactose anhydrous, magnesium stearate, cellulose microcrystallic.

Release form

Medicine Tizalud is issued in the form of tablets on 2 and 4 mg, on 30 pieces in one packaging.

Pharmacological action

Myorelaxation, central action.

Pharmacodynamics and pharmacokinetics

Tizalud is the muscle relaxant showing the central action.

Influence of a tizanidin on presynaptic α2-адренорецепторы causes oppression of processes of allocation of spinal interneuronels of exciting amino acids that leads to braking of polisinaptichesky distribution of an impulse in a spinal cord. By means of this mechanism of action the tone of muscular tissue goes down. In parallel with myorelaxation effect tizanidin shows moderately expressed anesthetizing action.

Tizalud's tablets are effective at acute cricks of muscles, and also chronic spasms of a cerebral and spinal etiology. Administration of drug reduces clonic spasms and spasticity of muscles therefore counteraction to the passive movements decreases and the possibility of active actions increases.

Indications to use

The muscular spasms at backbone pathologies which are followed by a pain syndrome including hemiplegia, spondylosis, osteochondrosis, myelosyringosis, lumbar and cervical syndromes.

The post-operational period after surgical intervention concerning an osteoarthritis of a femoral joint and hernias nuclei pulposi.

The pain syndrome and spasticity of muscles provoked by neurologic diseases, including a chronic myelipathy, multiple sclerosis, a cerebral palsy, degenerative changes of a spinal cord, a stroke, disturbances of blood circulation of a brain, craniocereberal injuries, spasms of the central genesis.

Contraindications

  • hypersensitivity to a tizanidin or other making ingredients of tablets Tizalud;
  • heavy pathologies of a liver;
  • periods of breastfeeding and pregnancy;
  • age till 18 years;
  • parallel therapy with reception of Ciprofloxacin, a fluvoksamin and other strong inhibitors of an isoenzyme CYP1A2.

With care:

Side effects

TSNS:

Cardiovascular system:

  • lowering of the ABP;
  • bradycardia.

Alimentary system:

  • dryness in an oral cavity;
  • dyspepsia;
  • nausea;
  • hepatitis;
  • increase of activity of "hepatic" transaminases;
  • liver failure.

Musculoskeletal system:

Others:

  • giperkreatininemiya;
  • increased fatigue.

Sharp cancellation of Tizalud after the combined reception with hypotensive drugs and long therapy and/or use of high doses, can lead to increase of the ABP, tachycardia, and in certain cases to an acute disorder of blood circulation of a brain.

Tablets Tizalud, application instruction

Pill of drug is taken orally (inside), washing down with water, irrespective of food.

The application instruction of Tizalud at the neurologic pathologies causing spastic painful reduction of muscles recommends to begin treatment with the daily dose in 6 mg accepted in three steps. Each next 3-7 days, depending on character of pain and a spasm, increase a dose by 2-4 mg. The maximum therapeutic effect is observed at reception of a daily dose in 12-24 mg. The dose of 36 mg is the most admissible daily dose.

For stopping of a painful spasm of skeletal muscles appoint 3-times daily reception of Tizalud on 2-4 mg. In especially difficult situations recommend additional reception of 2-4 mg for the night.

Duration of reception of Tizalud depends on dynamics of painful and muscular and tonic manifestations. Acute muscular pains usually demand carrying out therapy for 7-21 days. The chronic pain syndrome, depending on an origin and weight, can need carrying out more prolonged treatment which is defined in an individual order and sometimes proceeds on an extent till 1st year.

Overdose

At gross violation of the dosing mode and reception of the raised Tizalud's doses observed: the nausea passing into vomiting, development of hypotension, drowsiness, dizziness, a miosis, breath disturbances, concern, a coma.

Recommend an immediate gastric lavage, cleaning of intestines by means of an enema, reception of absorbent carbon, carrying out an artificial diuresis and further symptomatic therapy.

Interaction

The concomitant use of Tizalud with Ciprofloxacin, Fluvoksamin and other strong inhibitors of an isoenzyme CYP1A2, including Amiodaronum, Propafenon, Meksiletin, Cimetidinum, Enoksatsin, Norfloxacin, Pefloksatsin, Rofekoksib, Tiklopidin and oral contraceptives is not allowed.

Drugs of anti-hypertensive action increase risk of developing of bradycardia and lowering of the ABP.

Sedative drugs and ethanol, can strengthen sedations of a tizanidin.

Terms of sale

Tizalud's tablets are released from drugstores in the presence of the recipe of the doctor.

Storage conditions

Drug Tizalud is stored in the dark dry place, at a surrounding temperature to 25 °C.

Period of validity

Tablets, in original packaging, can remain for 24 months.

Special instructions

When carrying out long treatment by Tizalud, it is necessary to control a condition of a liver at least 1st once a month, in particular for the first 4 months of therapy.

Because of development threat of "a withdrawal ", at refusal of therapy, the dose of a tizanidin is lowered gradually.

At reception of tablets it is better to refuse driving of transport and carrying out exact or dangerous works.

Tizalud's analogs

Coincidence on the ATH code of the 4th level:

Tizalud's analogs, similar in the action, are provided by drugs: Liorezal, Baklosan, Mydocalmum, Tolperisonum, Tolperil and some other.

Zdravzona

  • Tizalud of 2 mg No. 30 tabletkiverofarm joint stock company
  • Tizalud of 4 mg No. 30 tabletkiverofarm joint stock company
to show still

Apteka24

  • Tizalud of a tablet 2 of mg No. 30 Kiev vitamin plant (Ukraine, Kiev)
  • Tizalud of a tablet 4 of mg No. 30 Kiev vitamin plant (Ukraine, Kiev)

Paniapteka

  • Tizalud of the tab. of 2 mg No. 30 Kiev vitamin plant
  • Tizalud of the tab. of 2 mg No. 30 Kiev vitamin plant
Section: For joints Anesthetics
in more detail

Education: Graduated from the Vinnytsia national medical university of N. I. Pirogov, pharmaceutical faculty, the higher pharmaceutical education – the specialty "Pharmacist".

Experience: Work in Koneks and Bios-Media pharmacy chains as "Druggist". Work as "Pharmacist" in Avicenna pharmacy chain of the city of Vinnytsia.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Tizalud surely consult with the attending physician.