Tobreks

Тобрекс Drug photo

The description is actual on 12.05.2014

  • Latin name: Tobrex
  • ATH code: S01AA12
  • Active ingredient: Tobramycinum (Tobramycin)
  • Producer: Alcon-Couvreur N.V. S.A.; Riyksveg 14, B-2870 Puurs, Belgium

Structure

1 ml of solution contains 3 mg of Tobramycinum as the main substance, and also as excipients chloride, boric acid, sodium sulfate, sodium hydroxide or sulphuric acid (for stabilization of the pH level), tilaksopol, the water purified are a part a benzalkoniya.

Release form

"Drop Teyner" on 5 ml with a possibility of dosing is issued in the form of transparent colourless or with a straw shade of solution in bottles droppers. 1 bottle in a cardboard pack.

Pharmacological action

Tobramycinum – the antibiotic operating on a wide range of activators and relating to group of aminoglycosides. In low concentration bacteriostatic action (inhibits 30S subunit of ribosomes and stops synthesis of a protein) is shown, in high concentration bactericidal action is more expressed (changes permeability of cellular membranes, causing a cytolysis).

Antibacterial activity is high on the relation: Staphylococcus spp. (including Staphylococcus epidermidis, Staphylococcus aureus and their penitsillinazaprodutsiruyushchy, koagulazanegativny and koagulazapozitivny strains), Streptococcus spp. (including beta and hemolitic strains of group "A", some not hemolitic strains, Streptococcus pneumoniae), Enterococcus spp., Escherichia coli, Proteus spp. (including Proteus vulgaris, Proteus mirabilis, indolpositive and indolnegative strains), Serratia spp., Enterobacter spp. (Enterobacter aerogenes), Providencia spp., Citrobacter spp., Haemophilus aegyptius, Morganella morganii, Acinetobacter calcoaceticus (Herellea vaginacola), Moraxella lacunata, some representatives of Neisseria spp. (including Neisseria gonorrhoeae).

Tobramycinum in an action spectrum is similar to gentamycin, but the first is more active concerning gentamitsinorezistentny strains and can be applied as choice drug at small efficiency of neomitsinsoderzhashchy eye drops.

Tobramycinum is allocated with high performance in relation to the infections caused by Pseudomonas aeruginosa.

Tobramycinum has a low performance concerning the most part of strains of the streptococci relating to group D.

Pharmacodynamics and pharmacokinetics

Absorption in a system blood stream is practically absent if drug is used locally.

Indications to use

Eye drops as well as oculentum of Tobreks, are applied to treatment of infectious and inflammatory damages of an eye and the fabrics surrounding it:

Tobreks's use at barley is also reasonable (meibomitis) and prevention of complications before ophthalmologic interventions.

Contraindications

Individual hypersensitivity to drug and its components.

Side effects of Tobreks

In 1,5% of cases the allergic reactions which are shown an itch, a slezootdeleniye, reddening of a conjunctiva are revealed.

In 1% of cases swelling and reddening a century, swelling of a conjunctiva, discomfort in an eye are revealed.
Less than in 1% of cases (chemosis), a blepharitis (an inflammation of edges a century), the keratitis (a cornea inflammation), eye pain, single ulcerations are revealed hemoz.

At prolonged treatment accession of fungal superinfection is possible.

Application instruction (Way and dosage)

The instruction on eye drops Tobreks and the instruction on eye drops of Tobreks 2kh differ in frequency rate of administration of drug: the first recommends to dig in on 1 drop 4-5 times a day, the second advises to apply on 1 drop 2-3 times a day; ointment of Tobreks is applied on 1 cm of a column 2 times a day.

Difference of Tobreks and Tobreks 2x in frequency rate of use is caused by more dense consistence of the last drug. This feature allows active ingredient to keep longer in a conjunctival sac and, therefore, to reduce the frequency of administration of drug without prejudice to therapeutic effect. The course of treatment makes 7-10 days.

It is possible to practice an instillation in special cases each hour, however after decrease in sharpness of symptoms it is necessary to return to the above-mentioned scheme. At night days it is recommended to supplement treatment with use of ointment of Tobreks for prolongation of contact with drug.

Overdose

Characteristics of this drug do not assume emergence of any symptoms of poisoning at its correct use, and also at accidental swallowing contents of one bottle.

Complaints in case of overdose by drug can be similar to side effects, observed at some patients (a dot keratitis, the raised slezootdeleniye, reddening, hypostasis and an itch a century).

If at topical administration overdose by drug of Tobreks nevertheless happened, it is recommended to wash out an eye warm water.

Interaction

It is necessary to exclude combined use of Tobreks with the following drugs:

Also it is not necessary to allow simultaneous use of Tobreks with the drugs having tetracycline in structure (because of contents in the first a tiloksapola).

Terms of sale

In Russia Tobreks is released without recipe, in Ukraine only according to the recipe.

Storage conditions

To store in protected from children and the place, unavailable to light, at a temperature of 17-27 °C, the open bottle needs to be used within 30 days.

Period of validity

3 years, on condition of tightness of packaging.

Special instructions

Unreasonable increase in frequency rate of reception and duration of use of drug can lead to emergence of microorganisms, insensitive to components of drug, including to a fungal infection of an eye. At emergence of symptoms of superinfection it is recommended to see a doctor.

Tobreks's analogs

Coincidence on the ATH code of the 4th level:

Tobreks 2x, Tobrosopt and Tobrimed are full analogs of Tobreks in a form of release and structure. From 51 to 34 hryvnias — such is in Ukraine the price of these analogs of eye drops, in Russia it fluctuates from 126 to 221 rubles.

Zdravzona

  • Tobreks 2X 0,3% of a drop eye 5 ml S.A bottle-kapelnitsaalcon-Cusi
  • Tobreks 0,3% of a drop eye 5 ml bottle-kapelnitsaalcon-Couvreur

Drugstore of IFC

  • Tobreks 2X of an eye. cap of 0.3% fl-cap of 5 ml, Alcon-Couvreurbelgiya
  • Tobreks eye. cap of 0.3% fl-cap of 5 ml, Alcon-Couvreurbelgiya
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Apteka24

  • Tobreks 2X eye drops 5mlalkon Kuzi S. A. (Spain)
  • Tobreksalcon-Couvreur (Belgium)

Paniapteka

  • Tobreks 2X of hot-smoked 0.3%-5mlalkon of Kuzi
  • Tobreks 2X of hot-smoked 0.3%-5mlalkon of Kuzi
  • Tobreks 2X of hot-smoked 0.3%-5mlalkon of Kuzi

BIOSPHERE

  • Tobreks 0,3% 5 ml of a drop glazn.
  • Tobreks 0,3% 3,5 g ointment glazn.
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Section: Antibiotics For eyes
in more detail

Education: Graduated from the Vitebsk state medical university majoring in "Surgery". At university headed Council of students' scientific society. Professional development in 2010 - in "Oncology" and in 2011 - in "A mammology, visual forms of oncology".

Experience: Work in an all-medical network 3 years the surgeon (The Vitebsk hospital of an emergency medical service, Lioznensky TsRB) and in combination the regional oncologist and the traumatologist. Work farm the representative within a year in the Rubicon company.

Provided 3 improvement suggestions on the subject "Optimization of an Antibioticotherapia depending on Species Composition of Microflora", 2 works took prizes in a republican competition review of student's scientific works (1 and 3 categories).
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