Trayfed

Трайфед Drug photo

The description is actual on 20.07.2016

  • Latin name: Trifed
  • ATH code: R01BA52
  • Active ingredient: Pseudoephedrine hydrochloride + triprolidina hydrochloride (Pseudoephedrine hydrochloride + Triprolidine hydrochloride)
  • Producer: "Al-Hikma Farmasyyutikalz", Jordan

Structure

In 1 tablet of a hydrochloride of pseudoephedrine of 60 mg, hydrochloride of a triprolidin of 2,5 mg. Magnesium stearate, silicon dioxide lactose, starch, MKTs, sodium of a kroskarmelloz, as excipients.

In 5 ml of syrup of a hydrochloride of pseudoephedrine of 30 mg, hydrochloride of a triprolidin of 1,25 mg. Sucrose, glitserol, Natrium benzoicum, sorbitol, dye, fragrance, water, excipients.

Release form

Tablets.

Syrup in bottles.

Pharmacological action

Antiedematous.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Antihistaminic drug which is used for treatment of the diseases of a nasal cavity which are followed by hypostasis mucous and a congestion, the allergic states connected with hyperproduction of a histamine.

Triprolidin is the antagonist of H1 receptors, suppresses a hyperemia and an itch which arise at development of a histamine in an organism.

Pseudoephedrine renders alpha adrenostimuliruyushchee (narrows vessels mucous respiratory tracts), the bronkhodilatiruyushchy and cardiopromoting effect, also stimulates TsNS. Reduces a hyperemia and puffiness of fabrics, a nose congestion, passability of bronchial ways improves. Promotes drainage of nasal bosoms and an Eustachian tube. Possesses the prolonged action. Trayfed-ekspektorant syrup in addition to a triprolidin, pseudoephedrine, contains also guayfenezin, having mucolytic effect — reduces viscosity of a phlegm and facilitates expectoration.

Pharmacokinetics

Active agents are quickly soaked up from a gastrointestinal tract. Pseudoephedrine shows the action in 15-20 min., and duration of his 3-4 h. Active ingredients are removed with a stake and urine. T1/2 period — 4-6 hours.

Indications to use

  • treatment of cough (bronchitis, obstructive bronchitis, bronchial pneumonia);
  • symptomatic treatment of rhinitises (vasculomotor, allergic, against cold) and sinusitis;
  • effects of endonozalny interventions.

Contraindications

  • arterial hypertension;
  • Ischemic heart disease, stenocardia;
  • hypersensitivity;
  • age till 6 months;
  • pregnancy, feeding by a breast;
  • joint reception with monoaminoxidase drugs (not to apply 2 weeks after their reception).

With care it is appointed at a diabetes mellitus, a prostate hypertrophy, a hyperthyroidism, an abnormal liver function and kidneys, the increased intraocular pressure. With extra care to appoint sick, accepting tricyclic antidepressants. Drivers and operators of cars should consider that drug can cause drowsiness.

Side effects

Trayfed, application instruction (Way and dosage)

Syrup Trayfed is applied at children from the 6th monthly age. To adults and children since 12 — 10 ml 3 times a day.

  • 6-12 years — 1 teaspoon three times a day;
  • 2-5 years — 1/2 teaspoon three times a day;
  • 6 months — 2 years — 1/4 teaspoons three times a day.

Trayfed-ekspektorant syrup can also be accepted from 6 months and in the dosage described above.

Trayfed children can only take a pill since 12 and the adult — on 1 tablet 3 a day.

At administration of drug alcohol intake is excluded.

Overdose

Overdose is shown by heartbeat, expansion of pupils, arrhythmia, increase of pressure, sleeplessness, vomiting, nausea, hallucinations (at children), a muscular tremor. It is recommended to wash out a stomach, to accept adsorbents.

Maintenance of important functions of an organism is carried out, at dominance of a convulsive syndrome antikonvulsant apply. It is possible to accelerate pseudoephedrine removal by the created diuresis or a hemodialysis.

Interaction

With care to use combinations with hypotensive drugs, inhibitors of monoaminoxidase and tricyclic antidepressants.

Terms of sale

It is released without recipe.

Storage conditions

Temperature is up to 20 °C.

Period of validity

2 years.

Trayfed's analogs

Terosim, Terofun, Zestra, Aktifed.

About Trayfeda

The main strategy in treatment of rhinitis, an inflammation of okolonosovy bosoms and respiratory tracts — elimination of hypostasis mucous a nose, recovery of a drainage of okolonosovy bosoms, optimization of process of an otkhozhdeniye of a phlegm and adjustment of motility of a ciliary epithelium of bronchial tubes.

The combination of two and three components in drug leads to the fact that in general it influences all links of a pathogeny at diseases of a respiratory path. Pseudoephedrine quickly eliminates a congestion of a nose and the complicated breath, renders less undesirable effects, in comparison with ephedrine. Nevertheless, it is necessary to remember that it has systemic vasoconstrictive action, often causes sleeplessness, drying mucous a nose, dryness in a mouth. All these undesirable effects are noted in responses.

  • "… Drug helped, but worked excitingly, could not put to bed in the evening. Probably for the night it is not necessary to give. And how to be if cough is more at night?".
  • "… On Trayfed in syrup there was a reaction — block and dryness in a mouth. Not to recognize the child. Stopped giving — everything was normalized".
  • "… Well helps my son, the lazolvana is much better".
  • "… Syrup well removes cough and obstruction for the second day. We are not fond of drug very much, in 3 days we pass to others (more often vegetable)".
  • "… For me Trayfed was rescue, coughed more than a month and tried everything that is possible. After syrup for the second day there came the simplification".

Parents are afraid to give to children drug as it contains pseudoephedrine and dependence is possible. It is not excluded if to accept constantly for this reason more than a week it is not recommended to accept. Especially, drug is not suitable for continuous treatment of bronchial asthma.

Section: For cough
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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