Trazodonum

Тразодон Constitutional formula

The description is actual on 03.11.2015

  • Latin name: Trazodonum
  • ATH code: N06AX05
  • Chemical formula: C19H22ClN5O
  • CAS code: 19794-93-5

Chemical name

2-(3-[4-(3 chlorophenyl) piperazin-1-silt] spent on drink) - [1,2,4] triazoles [4,3-a] pyridine-3 (2H) - it

Chemical properties

This substance – antidepressant, the antagonist of the return serotonin reuptake, derivative thiazolopyridine. The chemical compound has an appearance of the white crystal powder which does not have a specific smell, medicine is well dissolved in water (hydrochloride). The molecular mass of substance of about 371,9 grams on mol. Means is let out in the form of tablets for oral administration.

Pharmacological action

Antidepressive.

Pharmacodynamics and pharmacokinetics

The mechanism of effect of drug is not up to the end studied. Means has the expressed antidepressive effect, has tranquilizing and anksiolitichesky effect. However on the pharmacological properties medicine differs from typical representatives of this row. Substance does not inhibit a monoaminooxidase, does not stimulate the central nervous system, and blocks alfa1-adrenoceptors.

The drug Trazodonum possesses ability to selectively inhibit the return serotonin reuptake in a head brain, medicine acts as the antagonist 5-HT2A/2C of receptors. Active ingredient eliminates sleeplessness, fear, affective intensity, a mialgiya, a headache and heartbeat, reduces perspiration, eliminates uneasiness. At patients with a depression during treatment means observed improvement of quality and duration of a dream, recovery of physiological structure of process.

After reception of tablets inside within 30 minutes — 2 hours drug reaches the maximum concentration in blood. At parallel meal absorption speed decreases a little, substance is longer removed and its concentration is lower, than after reception on an empty stomach. Medicine breaks gistogematichesky barriers, well gets into biological liquids and fabrics (breast milk, bile, saliva and slime).

At medicine high extent of linkng with proteins of a blood plasma – about 87-96%. The metabolism of means proceeds in a liver, at the same time the active metabolite 1-m-hlorofenilpiperazin is formed. An elimination half-life of Trazodonum from 3 to 6 hours at single and till 9 o'clock at systematic reception. About 20% of drug are removed in not changed view with bile, 75% are allocated from an organism by means of kidneys. Completely substance is removed in 98 hours.

Indications to use

Drugs on the basis of Trazodonum appoint:

  • for treatment of a psychotic, neurotic, endogenous, somatogenic depression if the disease is followed by uneasiness, loss of appetite, a dream, agitation or block, decrease a libido, fatigue, suicide thoughts;
  • at bulimia;
  • for treatment of kleptomania;
  • to patients with phobias, panic attacks and uneasiness;
  • at benzodiazepine medicinal dependence;
  • for elimination of acute alcoholic abstinence;
  • at impotence, decrease in a sexual inclination;
  • as a prophylactic at migraine;
  • for elimination of a pain syndrome at a diabetic neuropathy.

Contraindications

Tablets cannot be applied:

  • at an allergy to Trazodonum;
  • to children till 6 flyings;
  • at intoxication sleeping pill or alcohol;
  • to pregnant women;
  • during a lactation.

It is recommended to be careful:

  • during recovery after a myocardial infarction;
  • with the lowered arterial pressure;
  • to patients with AV blockade;
  • at ventricular arrhythmia;
  • if earlier at the patient the priapism was observed;
  • at diseases of a liver and kidneys;
  • aged till 18 flyings;
  • at parallel reception of MAO inhibitors.

Side effects

Use of Trazodonum can provoke:

  • headaches, sleeplessness, psychosis, increased fatigue, dizziness;
  • weakness, drowsiness, hallucinations, confusion of consciousness;
  • dryness of mucous membranes, unpleasant smell and taste in a mouth, the raised salivation;
  • decrease in the ABP, cardiac arrhythmia, bradycardia or tachycardia, congestive heart failure;
  • tremor, spasms and attacks, spontaneous twitchings of muscles, paresthesias, diplopia, dyskinesia, hypomania;
  • caries, defeat of an oral cavity fungus Candida, various diseases of gums;
  • increase of level of amylase and bilirubin in blood;
  • liver diseases, jaundice;
  • increase of sexual activity, impotence, priapism, hit of an eakulyant in a bladder;
  • leukocytosis, leukopenia, hemolitic anemia, neutropenia;
  • the increased gas generation, nausea, diarrhea or lock, vomiting, cholestasia;
  • hamaturia, disturbance of a menstrual cycle, urination delay, hirsutism;
  • allergic enanthesis, itch, urticaria, mialgiya;
  • puffiness, psoriasis, painful feelings in a thorax, an alopecia.

Trazodonum, application instruction (Way and dosage)

Pill is taken inside, it is desirable before going to bed. It is sometimes reasonable to distribute a daily dosage on 3 receptions.

The initial dose makes 100 mg a day. Further it is possible to raise a dosage gradually each 3-4 days on 50 mg, the desirable therapeutic effect will not be reached yet. The maximum daily dosage – 450 mg of means. In the conditions of a hospital use of 0,6 grams of substance a day is admissible.

The average supporting dosage at an easy and moderate form of a depression makes 0,15 grams a day.

When using medicine as anxiolytic appoint 75 mg of substance a day, for 3 receptions.

Patients at the age of more than 65 years or the weakened patient can appoint no more than 0,3 grams of Trazodonum a day.

For children aged from 6 flyings the daily dosage is calculated from a ratio of 1,5-2 mg of funds for one kg of weight a day. At an urgent need it is possible to increase a dose to 6 mg by weight kg a day.

The course of treatment is defined by the attending physician.

Overdose

At overdose arise: vomiting and nausea, dizziness, incoordination, drowsiness and weakness, lowering of arterial pressure, spasms and attacks similar to epilepsy. Also characteristic changes on the electrocardiogram, strengthening and increases of frequency of emergence of side reactions are observed, up to an apnoea.

As therapy wash out a stomach, carry out an artificial diuresis, give to the patient absorbent carbon or other enterosorbents, carry out the supporting treatment, eliminate life-threatening symptoms. Medicine has no specific antidote.

Interaction

Pseudoephedrine at a combination to means can cause panic, alarm, depersonalization and opacification of mind.

Special cases of development of cardiac arrhythmia at a drug combination to Amiodaronum are described and decrease in antikoagulyatny activity of warfarin.

Reception of means with digoxin can lead to increase of its plasma concentration and development of intoxication by cardiac glycoside.

Medicine increases plasma concentration of carbamazepine.

The combination of reception of Trazodonum to salts of lithium can cause a tremor, neurotoxic effects.

Drug is not recommended to be combined with ethanol, it strengthens oppression of TsNS.

The concomitant use of substance and thioridazine leads to growth of plasma concentration of the last.

Tryptophane at a combination to medicine can cause psychosis, a hypomania, disgust for food.

Isolated cases of strengthening of side effects from reception of Phenytoinum and fluoxetine at parallel use of Trazodonum are described.

Trifluoperazin and Chlorpromazinum can strengthen arterial hypotension.

Terms of sale

The recipe is required.

Special instructions

To avoid development neytro-and the general blood test is recommended to carry out leukopenias periodically. Also during therapy by medicine it is desirable to do an ECG, especially patients with the increased risk have developments of arrhythmia.

In the course of treatment it is necessary to watch closely the patients having suicide bents, especially a pas the first stages of carrying out therapy.

If the patient taking a pill had a priapism, a leukopenia or a neutropenia, then medicine needs to be cancelled immediately. In other cases drug withdrawal has to be made gradually.

During treatment it is impossible to steer the car or to carry out the dangerous, demanding high concentration of attention types of activity.

When using drug expansion of pupils is often noted, it can promote development of closed-angle glaucoma in patients, with anatomically narrow corner of an anterior chamber of an eye.

During treatment the probability of development bleeding, ventricular tachycardia and sudden death is available means. However experimentally the interrelation between administration of drug and development of such reactions was not proved.

To children

Extra care is required from children aged from 6 till 18 flyings at treatment by antidepressants.

Elderly

To persons 65 years are more senior it is necessary to be careful, correction of a dosage can be required.

With alcohol

Drug cannot be combined with alcohol.

Trade names of this substance: Trittico, Azona.

About Trazodonum

Responses on medicine demonstrate that antidepressants need to be drunk only according to the recommendation and after consultation with the attending physician. Patients, at successfully picked up dosage, are happy with result of treatment, the psychological state is normalized, the depression recedes, fears cease to disturb. Side reactions are shown not more often than it is declared in the instruction, most often complain of drowsiness, weakness, headaches and lowered by the ABP. At some patients difficulties with awakening are observed in the morning if the pill was taken before going to bed.

Trazodonum price where to buy

It is possible to buy Trazodonum as a part of Azon's drug. The cost of tablets fluctuates from 40 (30 tablets on 100 mg) to 500 (100 tablets on 100 mg) rubles. It will be possible to buy medicine with a trade name Trittico approximately for 600-700 rubles, 20 tablets on 150 mg.

Section: Active ingredients
PAY ATTENTION! Information on active ingredients on the website is help generalizing, collected from public sources and can form the basis for making decision on use of these substances it is not aware of treatment. Before substance Trazodonum use surely consult with the attending physician.