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Levonorgestrel, ethinylestradiol, monohydrate of lactose, potato starch, talc, sodium edetat, glucose liquid, magnesium stearate, macrogoal, gelatin, magnesium carbonate, sucrose, calcium carbonate, polividon, titanium dioxide, karnaubsky wax, hydrate of iron oxide.
Dragee of red-brown, beige, white flowers in the blister in cardboard packaging No. 21 and 63.
Pharmacodynamics and pharmacokinetics
Drug oppresses secretion of the gonadotropic hormones produced by a hypophysis. Contraceptive action is caused by several mechanisms.
Levonorgestrel — is a gestagenny component, derivative a 19-nortestosterona, possesses high activity, on this indicator exceeds progesterone (hormone of a yellow body). Works without any metabolic transformations, at the level of receptors.
Ethinylestradiol — an oestrogenic component.
Drug has the combined effect. Levonorgestrel blocks release process a rileasing of factors of a hypothalamus, oppresses production of gonadotropic hormones that leads to delay of process of maturing and an ovulation (an exit of the ovum prepared for fertilization). Contraceptive effect of levonorgestrel amplifies ethinylestradiol which maintains high viscosity of slime of a neck of uterus that interferes with hit of active spermatozoa in a cavity of the uterus.
At regular administration of drug at women the menstrual cycle is normalized that warns gynecologic diseases of various genesis.
Actively active ingredients of drug are completely and quickly soaked up in a gastrointestinal tract. Tmax of levonorgestrel makes about 2 hours, ethinylestradiol – one hour. Both substances are emitted with breast milk. Biotransformirutsya in a liver. An elimination half-life – 3-6 hours. Drug with urine and a stake is removed.
Indications to use
- Treatment of functional frustration of a menstrual cycle (premenstrual syndrome, dysmenorrhea, metrorrhagia dysfunctional).
High sensitivity to drug, the period of pregnancy and a lactation, cholecystitis, liver diseases, chronic colitis, diseases of cardiovascular system with the expressed dysfunction, hereditary hyperbilirubinemias, thromboembolisms, malignant new growths of an endometria and a mammary gland, the expressed arterial hypertension, hemolitic anemia, a diabetes mellitus, vaginal bleedings of the obscure genesis, an otosclerosis, to women is more senior than 40 years.
The headache, nagrubaniye of mammary glands, nausea, vomiting, increase in body weight, voice coarsening, intermenstrual bloody allocations, decrease in a libido, is more rare — conjunctivitis, the century, a vision disorder swelled.
At prolonged use of drug increased fatigue, decrease in hearing, jaundice, venous thromboembolisms, spasms of gastrocnemius muscles, skin rashes, a generalized itch, vagina candidiasis, increase of the ABP, increase in quantity of epileptic seizures, a hyperglycemia can be noted.
Triziston, application instruction (Way and dosage)
To accept from the first day of a menstrual cycle on one dragee a day for 3 weeks: the first 6 days — a dragee of red-brown color; from 7 to 12 days — a dragee of white color, from 13 to 21 days — a dragee of beige color. After the end of reception it is necessary to take a week break after which calendar menstrual bleeding begins. For the purpose of maintenance of constant level of hormones in blood it is necessary to observe an interval of reception of the next dose on average at the level of 25 hours and should not exceed 36 hours.
Data are absent.
Antiepileptic drugs, barbiturates, derivatives of pyrazyl ketone and streptocides strengthen process of biotransformation of the steroid hormones which are a part of drug. At joint reception with antimicrobic HP (polymyxin B, ampicillin, tetracyclines, chloramphenicol, rifampicin, streptocides, Neomycinum), disturbance of normal intestinal microflora is resulted by risk of decrease in contraceptive efficiency of drug.
At reception of medicines of gestagen-oestrogenic action there can be a need of behavior correction of dosing of indirect anticoagulants and hypoglycemic means.
Terms of sale
According to the recipe.
At a temperature up to 25 °C.
Period of validity
In general, responses of the women accepting Triziston for the purpose of contraception positive.
"… I take a pill Triziston for five years, in general the health is normal, only sometimes feels sick. However, it was necessary to leave off smoking as the gynecologist advised and to limit itself in reception alcohol of the containing drinks. Insignificant and I it quickly dump increase in weight".
Some women complain of the arising nausea or vomiting after reception of tablets. In that case try to change time of administration of drug (for example, accept in the mornings, instead of evening and vice versa).
Some visitors of forums ask what to choose: Triziston or Trikvilar? There are no basic distinctions between drugs. Both treat the combined low-dosed three-phase is oestrogenic-gestagennym and both provide high contraceptive performance.
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Triziston surely consult with the attending physician.