Цефалексин Drug photo

The description is actual on 02.07.2016

  • Latin name: Cefalexin
  • ATH code: J01DB01
  • Active ingredient: Cefalexin (Cefalexin)
  • Producer: Biochemist, Synthesis, Joint-stock Kurgan company of medical supplies and products of joint stock company, Northern star (Russia); Grindeks (Latvia); Borisovsky plant of medical supplies (Republic of Belarus); Belmedpreparata of RUP (Republic of Belarus); Hemofarm (Serbia)


In 1 capsule of 250 mg or 500 mg of cefalexin. Magnesium stearate, cellulose microcrystallic — as excipients.

In 5 ml of suspension of cefalexin of 250 mg. Sodium saccharinate, citric acid, iron oxide, gum guar, Natrium benzoicum, simetikon, sucrose, fragrance — as excipients.

Release form

Tablets in a cover 0,25g. Capsules of 250 mg and 500 mg. Granules for preparation of suspension of 250 mg / 5 ml in a bottle.

Pharmacological action


Pharmacodynamics and pharmacokinetics


The antibiotic Cefalexin belongs to generation cephalosporins I. Breaks synthesis of a cellular membrane of microorganisms that leads to their death. Shows activity concerning streptococci, escherichias, a protea, klebsiyet. Lower activity concerning Neisseria gonorrhoeae, Shigella spp., Neisseria meningitidis, Salmonella spp., therefore it is not applied in clinic of the diseases caused by these microorganisms.

 Morganella morganii, Clostridium spp is inefficient concerning Enterococcus faecalis Proteus vulgaris., Pseudomonas aeruginosa. He are sensitive to it also metitsillinrezistentny staphylococcus.

Collapses the beta lactamelements allocated by gram-negative microorganisms.


At intake it is well soaked up and bioavailability makes 90–95%. The maximum concentration in blood is defined in 1 hour, and necessary concentration remains 4–6 h. For 10–15% contacts blood proteins. It is evenly distributed in many fabrics and liquids of an organism: badly gets through GEB, passes through a placenta. It is not metabolized. T1/2 makes 0,8–1,2 h. About 89% are brought also insignificant part with bile. At a renal failure time of removal is extended and increases concentration.

Indications to use


This antibiotic cannot be accepted at:

  • the revealed hypersensitivity;
  • pregnancies;
  • feeding by a breast;
  • deficit of invertase;
  • intolerance of fructose.

With care it is appointed at pseudomembranous colitis, a renal failure, aged till 6 months (suspension).

Side effects

Application instruction of Cefalexin (Way and dosage)

Suspension Cefalexin, application instruction

Suspension reception inside is recommended to children till 10 flyings. 1 ml of ready suspension contains 50 mg of cefalexin, and 5 ml 250 mg.

Approximate dose for children:

  • till 1 year — 2,5 ml of suspension 3-4 times a day;
  • from 1 year to 3 flyings — 5 ml 3 times;
  • from 3 to 6 years — 7,5 ml 3 times;
  • from 6 to 10 years — 10 ml 3 times;
  • from 10 flyings to 14 flyings — 10 ml 3 times.

In each case the dose and frequency rate of its reception is specified by the doctor depending on a disease and its weight. In certain cases (not heavy infections of skin, urinary tract, pharyngitises) the dose is divided into 2 receptions, and at a severe disease it is appointed to 6 times a day. 2-3 more days after clinical improvement are recommended to use drug.

For preparation of suspension water to a mark in a bottle is added to a bottle and shaken up. It is possible to store suspension at the room temperature 2 weeks. Before the use it is well shaken up.

Tablets and capsules accept inside in 30 min. prior to food. An average dose for adult 250–500 mg each 6 h, 4 times a day. Thus, the daily dose makes 1–2 g (not less), if necessary it increases to 4 g that corresponds to the maximum SD for adults, also 6 years are more senior than children. Course of treatment from 7 to 14 days.

At a renal failure the maximum SD — 1,5 g, divide it into 2–4 receptions. At treatment positive reaction of urine to glucose can be false. It is not recommended to take alcohol. (Pricks) this drug has no injection forms — only a form for oral administration. The representative of injection cephalosporins I of generation is Cefazolin, the II generations — Tsefuroksim, in their III generation much more — Tsefotaksim, Tseftriakson, Tsefoperazon, the Ceftazidime, Tsefoperazon/sulbaktam.


Overdose is shown: vomiting, nausea, pains in a stomach, diarrhea, emergence of blood in urine.

Treatment: absorbent carbon, monitoring of functions of an organism and electrolytic balance.


Cefalexin strengthens effect of indirect anticoagulants. The risk of damage of kidneys increases at use with Furosemide, phenylbutazone, aminoglycosides, Acidum etacrynicum, polymyxins.

At use with Metforminum correction of its dose is necessary. Salicylates and Indometacin slow down removal of active ingredient.

Terms of sale

It is released according to the recipe of the doctor.

Storage conditions

Temperature of storage is up to 25 °C.

Period of validity

3 years.

Cefalexin for children

In children's practice the peroral way of administration of medicines is the main way of introduction as the least traumatic. For this purpose there are special children's forms — syrups and suspensions. Among antibiotics the leading position is taken by cephalosporins as they have a wide range of bactericidal action, good tolerance, are steady against beta lactamelements, differ in convenience of dosing, seldom found side effects.

Cephalosporins are alternative to penicillin at treatment of respiratory infections, ENT organs. The main area of their use in pediatric practice — not heavy infections. So, Cefalexin to children is applied at quinsies, sinusitis, otitises, cervical lymphadenites, streptococcal or staphylococcal infections of skin. It is noted that penicillin which uses for treatment of quinsy are not so effective as cephalosporins which cause an eradikation of a β-hemolitic streptococcus of group A and effective recovery of the child.

Cephalosporins remain in fabrics of almonds in bactericidal concentration whereas concentration of penicillin quickly decreases. Sinusitis is frequent complication of a SARS and occurs at 10% of sick children. At bacterial sinusitis antibiotics (in this case cephalosporins are more effective) are an obligatory component of therapy. Suspension to children can be appointed since the birth, however the first 6 months with extra care. The recommended doses are stated above, however the doctor, proceeding from a situation, carries out dose adjustment.

Analogs of Cefalexin

Coincidence on the ATH code of the 4th level:

The analogs having similar effect: Zolin, Cefazolin. Drugs with one active ingredient: Keflexum, Leksin, Ospeksin.


  • Cefalexin 500 of mg No. 16 kapsulykhemofarm A.D.
  • Cefalexin 250 of mg No. 16 kapsulykhemofarm A.D.
  • Granule cefalexin for A.D suspension 250mg/5ml 40gkhemofarm.
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  • Granule cefalexin for preparation of suspension 250mg/5ml 100 of ml No. 1khemofarm (Yugoslavia)
  • Tsefaleksinborshchagovsky HFZ (Ukraine, Kiev)


  • Cefalexin gran. for susp. 250mg/5ml 100 ml No. 1borshchagovsky of HFZ
  • Cefalexin gran. for susp. 250mg/5ml 100 ml No. 1borshchagovsky of HFZ
Section: Antibiotics
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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