Cefazolin

Цефазолин Drug photo

The description is actual on 30.11.2015

  • Latin name: Cefazolin
  • ATH code: J01DB04
  • Active ingredient: Cefazolin (Cefazolin)
  • Producer: CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. (China), Serena Pharma Pvt. Ltd., M.J.Biopharm, Jodas Expoim Pvt. (India), LEKKO of closed joint stock company, DEKO company, Biosynthesis, Ruzfarm, Krasfarm, Farmasintez of joint stock company (Russia), Belmedpreparata of RUP (Belarus)

Structure

The recipe on Latin reports that rolled into one means cefazolin without impurity of additional components contains.

Release form

The medicine is issued in the form of ochroleucous or white powder which is dissolved for carrying out intramuscular or intravenous injections. Drug is packed into bottles. Such form of release as Cefazolin in tablets is not on sale.

Pharmacological action

This medicine is a semi-synthetic antibiotic with antibacterial action of a wide range.

Pharmacodynamics and pharmacokinetics

Pharmacological effect of drug is based on blocking of biosynthesis of cell walls of microbes. The antibiotic Cefazolin is active in relation to gram-positive (Streptococcus spp., Staphylococcus spp.) and to gram-negative bacteria (to Klebsiella spp., Escherichia coli, Treponema spp., Haemophilus influenzae, Proteus mirabilis, Neisseria gonorrhoeae, Enterobacter aerogenes).

Drug is badly soaked up from a gastrointestinal tract at internal use therefore it is used for intravenous and intramuscular injections. After intramuscular pricks in a dosage of 0,5 g the maximum concentration is observed 1-2 hours later. Communication with proteins of plasma – about 85%.

Active agent of drug gets into a bone tissue, and also pleural, ascitic and synovial liquids, but is not defined in a nervous system.

Time of semi-removal of medicine makes about 1,8 hours. Drug is excreted with urine in an invariable look.

At intramuscular pricks about 80% of a dose are removed days later. In case of dysfunction of kidneys time of semi-removal from plasma increases.

Indications to Cefazolin use

Indications to use Cefazolin has the following:

  • infections of zhelchevyvodyashchy and urinary tract;
  • infectious diseases of respiratory tracts;
  • inflammations in the field of an abdominal cavity and bodies of a small pelvis;
  • blood poisoning;
  • peritonitis and sepsis;
  • skin infections after burns, surgical interventions and wounds;
  • heart cover inflammation;
  • infections of bones and joints;
  • venereal diseases;
  • infectious skin diseases;
  • mastitis.

From what drug will be effective in each separate case, it is necessary to consult at the specialist. Exact indications to use of Cefazolin are known only by the doctor. For example, it can recommend drug at quinsy, skin infections or blood poisoning.

Medicine is also applied in veterinary practice to cats. Pricks help at blood poisoning, peritonitis, meningitis, and also many infectious diseases.

Contraindications

The main contraindications to use of medicine: individual intolerance and age till 1 month.

Side effects

Use of a medicine can cause the following side effects:

Tranzitorny increase in activity of transaminases of a liver, acute anaphylaxis, arthralgias, Quincke's disease, leukopenia (in a reversible form), thrombocytopenia, a neutropenia, dysfunction of kidneys is in rare instances noted.

Application instruction of pricks of Cefazolin (Way and dosage)

When appoint Cefazolin pricks, the application instruction reports that dosages and duration of a course can be different depending on a disease and individual sensitivity of patients. A day dosage for adults from 1 to 6 g. Injections do 2-3 times daily. Therapy is expected at most 7-10 days.

The drug is administered in oil or in / century. Depending on it solve, than to dissolve Cefazolin. At intramuscular introduction medicine gets divorced water or solution of sodium of chloride. For intravenous pricks sodium chloride is used generally. At the same time the drug is administered slowly. Time of introduction of about 5 minutes.

If to the patient put a dropper, as a rule, part an antibiotic with glucose, and sodium use chloride only in rare instances.

For therapy of an inflammation of a cover of heart, joints, purulent pleurisy, bones, an abdominal cavity, blood poisoning 3 times enter every day 1 g of medicine. At dysfunction of kidneys the dosage needs to be reduced twice.

Drug cannot be integrated in one syringe with other antibiotics.

In addition to water and sodium of chloride medicine also sometimes is parted with Novocaine. It is anesthetic for topical administration by means of which it is possible to reduce painful feelings at introduction. In medical practice this drug is used for a long time so there is a settled scheme how to dissolve Cefazolin with Novocaine. The last take 0,25% in concentration. Before dissolving with Novocaine this medicine, no additional manipulations are required. It is only enough to enter 2-3 ml to an antibiotic, and then it is good to shake up. As a result ready solution for disposable turns out.

According to some indications drug are also used in veterinary practice instead of applying tablets. In this case it is parted in Lidocaine or Novocaine. The dosage for cats depends on the pet's weight, it is calculated so that 10 mg were on 1 kg. Therapy lasts 5-10 days. Before use of medicine it is necessary to consult at the veterinarian.

Often as the analog of drug for people is used Tsefazolin Akos. It is also entered by means of intramuscular and intravenous pricks (struyno and kapelno). The application instruction Cefazolin of Akos reports that the average daily dosage for adults makes 1 g. It is necessary to enter them 2 times a day. The maximum dose in days should not exceed 6 g. If necessary it is possible to increase frequency rate of use to 3-4 times a day. The average duration of therapy – 7-10 days.

The average daily dosage for children makes 25-30 mg/kg, and in case of heavy infections – 100 mg/kg.

At dysfunction of kidneys of a dose are adjusted.

For intramuscular injections the antibiotic in a dose of 500 mg is mixed from 2 ml of water, 1 g part in 2,5 ml of water. For intravenous administration medicine is mixed from 5 ml of water and entered 3-5 minutes.

Overdose

Administration of drug in the raised doses can cause dizziness, a headache and paresthesias. People with a renal failure in a chronic form can have neurotoxic phenomena. Spasms, tachycardia and vomiting are noted.

In case of toxic reactions and signs of overdose removal of medicine can be accelerated by means of use of a hemodialysis.

Interaction

At a drug combination to aminoglycosides, Rifampicin, Vancomycinum the synergism of antimicrobic action is noted. Aminoglycosides increase probability of emergence of damage of kidneys. Drug is incompatible with them.

It is undesirable to combine a medicine with anticoagulants and diuretics.

Interaction with means which inhibit canalicular secretion increases the level of active agent of drug in blood, increases probability of emergence of toxic reactions and slows down removal time.

Terms of sale

The medicine is on sale only according to the recipe of the specialist.

Storage conditions

Optimal conditions of storage – the dry and dark place. Temperature is no more than 5 °C.

Period of validity

2 years.

Analogs of Cefazolin

Coincidence on the ATH code of the 4th level:

    The following analogs of Cefazolin are known:

    • Tsefazeks;
    • Tsefazolin-Astrafarm;
    • Cefazolin of Akos;
    • Reflin;
    • Tsezolin;
    • Tsefazolin-Farmeks;
    • Cefamezinum.

    All listed medicines are on sale in the form of powder. Widespread analogs in tablets are not issued.

    Cefazolin to children

    Cefazolin to children gets divorced only in solutions of Novocaine or Lidocaine depending on individual portability. As a rule, more expressed analgesic effect renders Lidocaine.

    Solution is prepared just before use. The Cefazolin dosage to children is calculated, proceeding from character of a disease and individual portability of medicine.

    Zdravzona

    • Tsefazolin-AKOS powder for solution 500 of mg No. 50 flakonysintez joint stock company
    • Tsefazolin-AKOS powder for solution 500 of mg No. 1 flakonsintez joint stock company
    • Tsefazolin-AKOS powder for solution 500 of mg No. 1 a bottle/double /
    • Cefazolin powder for solution 1 of No. 1 of joint stock company of bottle/Krasfarma/Krasfarm
    • Tsefazolin-AKOS powder for solution 1 of No. 10 flakonysintez joint stock company

    Drugstore of IFC

    • Na-salt cefazolin of a time for in in/in, 1 g No. 1 in oil, Biosynthesis (Penza) Russia
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    Apteka24

    • Tsefazolinborshchagovsky HFZ (Ukraine, Kiev)
    • Tsefazolinkiyevmedpreparat (Ukraine, Kiev)
    • Tsefazolinkiyevmedpreparat (Ukraine, Kiev)
    • Cefazolin powder for injections 0.5g a bottle No. 5darnitsa (Ukraine, Kiev)
    • Cefazolin powder for injections of 1 g a bottle No. 5darnitsa (Ukraine, Kiev)

    Paniapteka

    • Cefazolin of a time. for infection. 1 g fl. No. 5
    • Cefazolin of a time. for infection. 1 g fl. No. 5
    • Cefazolin of a time. for infection. 1 g fl. No. 5

    BIOSPHERE

    • Tsefazolin-AKOS 1 g No. 1 por.d / solution for in.flak. Synthesis of joint stock company (Russia)
    • Cefazolin sodium salt of 1 g No. 1 of a time. for in.fl. Borisovsky ZMP (Belarus)
    • Cefazolin sodium salt of 1 g No. 1 of a time. for in.fl. Krasfarm (Russia)
    • Cefazolin sodium salt of 1 g No. 1 of a time. for in.fl. Biosynthesis (Russia)
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    Section: Antibiotics Antimicrobic
    PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Cefazolin surely consult with the attending physician.