Tsefutil

Цефутил Drug photo

The description is actual on 02.08.2016

  • Latin name: Cefutil
  • ATH code: J01DC02
  • Active ingredient: Tsefuroksim (Cefuroxime)
  • Producer: Pharma International (Jordan); Megalump of Ltd company (Ukraine)

Structure

In 1 tablet of a tsefuroksim of an aksetil of 500 mg 250 mg or 125 mg. MKTs, silicon dioxide, sodium lauryl sulfate and kroskarmelloz, magnesium stearate, dye as excipients.

Release form

Tablets in a cover on 125, 250 and 500 mg.

Pharmacological action

Antibacterial.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The antibiotic of a tsefalosporinovy row, is steady against β-lactamelements. Its bactericidal action is connected with oppression of synthesis of a cellular membrane of microorganisms. It is highly effective concerning stafilokokk (including penitsillinrezistentny strains), streptococci, an escherichia, a clostridium, a salmonella, a protea, Haemophilus influenzae and parainfluenzae, Moraxella, Neisseria gonorrhoeae. Are not sensitive to the drug Clostridium difficile, Acinetobacter calcoaceticus, Campylobacter spp., Listeria monocytogenes.

Pharmacokinetics

At intake it is absorbed in intestines on which mucous membrane it is hydrolyzed and gets to a blood stream. The maximum concentration in plasma is defined in 2–3 hours. Well gets into all fabrics, through a placental barrier and GEB. T½ is 1–1,5 h. Linkng with blood proteins reaches 35–55%. It is during the day removed by kidneys. At a dialysis the level of a tsefuroksim decreases.

Indications to use

Contraindications

With care it is appointed at pregnancy in the I trimester.

Side effects

Tsefutil, application instruction (Way and dosage)

Pill Tsefutil is taken inside after food for the best assimilation. At the majority of uncomplicated infections (bronchitis, pyelonephritis) appoint Tsefutil 250 mg 2 times a day. At heavy infections the dose is raised to 1 g a day, having divided into two receptions. Cystitis — 125 mg 2 times a day. Duration of a course is from 5 to 7 days.

At treatment of pneumonia begin treatment with intramuscular injections within 3 days with the subsequent transition to administration of drug inside — 500 mg twice a day. At uncomplicated gonorrhea — 1 g of drug once. At Lyme's illness accept 500 mg 2 times a day. To patients of advanced age and patients with a renal failure appoint usual doses and no more than 1 g a day.

The tableted form is applied also at children since 3. At the majority of infections appoint Tsefutil 125 mg twice a day. At heavy infections — on 250 mg twice. Since 12 doses of adults are recommended.

Overdose

It is shown by psychomotor excitement and spasms. The gastric lavage, reception of sorbents is undertaken and symptomatic therapy is carried out. Active ingredient is removed at a hemodialysis.

Interaction

The drugs reducing acidity reduce bioavailability of a tsefuroksim. Use with phenylbutazone and probenetsidy leads to increase of concentration of active ingredient in plasma. Tsefuroksim reduces efficiency of oral contraceptives.

Use with diuretics (furosemide, Acidum etacrynicum), aminoglycosides, colistin, polymyxin, Amphotericinum increases risk of emergence of a renal failure. Reception with antibiotics aminoglycosides also causes a renal failure. Simultaneous use with macroleads, tetracyclines and chloramphenicol is not recommended.

At a combination to erythromycin antibacterial action can be weakened. It is impossible to accept with NPVS in a type of the increased risk of bleeding.

Terms of sale

According to the recipe.

Storage conditions

Temperature is up to 25 °C.

Period of validity

Tablets of 125 mg and 250 mg — 3 years.

Tablets of 500 mg — 4 years.

Tsefutil's analogs

Coincidence on the ATH code of the 4th level:

Tsefuroksim, Kimatsef, Zinatsef, Taksotsef, Aksetin, Ketotsef.

About Tsefutile

Advantage of tsefalosporinovy antibiotics of the II generation is the high speed of bactericidal effect, high activity at purulent processes and post-operating rooms is purulent - septic complications that is explained by ability well to get through a membrane of abscesses. This drug differs in simplicity of use, the minimum toxicity moderated by the cost and low frequency of side reactions.

Separately taken generation cephalosporins I and II, are considered as effective and safe remedies at pregnant women at pyelonephritises and pneumonia. Choice antibiotics at pneumonia at all other patients are macroleads in a combination with cephalosporins of the II generation. If at the same time it is applied karbotsistein or AZZ, then they strengthen penetration of a tsefuroksim into a bronchial secret, increasing its efficiency. Efficiency and convenience of use of drug in out-patient conditions explain its wide use. However responses inconsistent that is possibly connected with disease severity and nonsensitivity of microorganisms to this antibiotic.

  • "… There was an obstructive purulent bronchitis. Spent on drink 7 days. The antibiotic helped — it became much easier. Did not notice side reactions".
  • "… Tsefutil helped me from cystitis".
  • "… It was pleasant to me, treated an angina follicularis. In the evening Tsefutil drank 500 mg — it was already easier in the morning".
  • "… There was otitis, appointed this antibiotic. Spent on drink a full course, but in recent days in the evenings there was a feeling of fear and a fever, think that from it".
  • "… Appointed at quinsy. Spent on drink week, effect — zero".
  • "… Tsefutil weak drug, drank at bronchitis, but effect was a little".
  • "… Effect any, from side reactions severe candidiasis. I cannot already cure month".

Apteka24

  • Tsefutil of a tablet coated 125 mg No. 10farma Interneshenal (Jordan)
  • Tsefutil of a tablet coated 250 mg No. 10farma Interneshenal (Jordan)
  • Tsefutil of a tablet coated 500 mg No. 10farma Interneshenal (Jordan)

Paniapteka

  • Tsefutil of the tab. p / about 125 mg No. 10farma Interneshenal
  • Tsefutil of the tab. p / about 125 mg No. 10farma Interneshenal
  • Tsefutil of the tab. p / about 125 mg No. 10farma Interneshenal
Section: Antibiotics
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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