Tsetirizin

Цетиризин Drug photo

The description is actual on 02.07.2016

  • Latin name: Cetirizine
  • ATH code: R06AE07
  • Active ingredient: Tsetirizin (Cetirizine)
  • Producer: Obolenskoye, VERTEXUM, Ozone of Ltd company, Berezovsky pharmaceutical plant (Russia), Glochem Industries (India)

Structure

In 1 tablet — a tsetirizina dihydrochloride of 10 mg. MKTs, silicon dioxide, lactoses monohydrate, magnesium stearate as auxiliary components.

B1 of ml of drops — a tsetirizina of dihydrochloride of 10 mg. The benzoic acid, propylene glycol, glitserol, water, sodium acetate as excipients.

Release form

  • Tablets in a cover Tsetirizin Teva of 10 mg.
  • Drops Tsetirizin Geksal for intake in bottles on 10 ml or 20 ml.

Pharmacological action

Antiallergenic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Blocker of H1-histamine receptors, competitive antagonist of a histamine. Eliminates manifestations of allergic reactions, possessing antiexudative and antipruritic action. Reduces permeability of capillaries, eliminates a spasm of muscles and skin reaction (at a cold urticaria). Reduces hyperreactivity of bronchopulmonary system at patients with asthma in response to release of a histamine.

Almost has no anticholinergic and sedative effect. The effect is observed in 1 hour, the maximum of action is defined in 4 hours, and duration of 24 hours. Action lasts 3 days after the end of treatment. Against treatment tolerance to effect of drug does not develop.

Pharmacokinetics

At intake it is well soaked up. Cmax is defined in blood by 1 h. Contacts proteins for 93%. Does not kumulirut. It is metabolized to an inactive metabolite, 60% are brought by kidneys for 96 hours and small part of active ingredient (10%) — through intestines. T1/2 makes 7-10 p. T1/2 at children of 6-12 years — 6 h. Increase in T1/2 at a renal failure and a liver is noted.

Indications to use

Symptomatic treatment:

Contraindications

  • hypersensitivity;
  • age till 6 flyings (for tablets);
  • pregnancy;
  • feeding by a breast;
  • the expressed renal failure;
  • glyukozo-galaktozny malabsorption;
  • lactose intolerance.

With care it is appointed at a heavy renal failure, at advanced age, at a concomitant use of barbiturates, ethanol, opioid analgetics, benzodiazepine derivatives. During reception to avoid managements of transport.

Side effects

The met side reactions are more often:

  • diarrhea;
  • paresthesias;
  • excitement;
  • itch, rash;
  • adynamy.

Seldom met side reactions:

Application instruction of Tsetirizin (Way and dosage)

Drops Tsetirizin Geksal, application instruction

To adults and children since 12 appoint 20 drops (that corresponds to 10 mg), it is better in the evening. To children of 6 - 12 years — 20 drops in the evening, from 2 to 6 years — 10 drops in the evening, from 1 to 2 flyings of 5 drops 2 times a day.

To elderly patients the dose is not changed. At a renal failure the recommended dose is reduced twice. At a liver failure the dose is selected individually. Treatment duration at seasonal allergic rhinitis of 3 — 6 weeks. If blossoming of plants not long, and pollen influences quickly – one week.

Application instruction Tsetirizin Teva

Pill is taken inside, entirely, it is better in the evening, considering sedation. To adults and children since 12 appoint 10 mg a day. Children are 6-12 years weighing more than 30 kg old — 10 mg once a day, weighing less than 30 kg — 5 mg once a day.

Overdose

Overdose is shown by drowsiness at adults, at children concern and irritability, an urination delay, a lock, dryness in a mouth, expansion of pupils, tachycardia.

Treatment consists in a gastric lavage and purpose of enterosorbents. The symptomatic treatment is carried out. The antidote is absent. The hemodialysis is not effective.

Interaction

Interaction with Cimetidinum, Erythromycin, Ketokonazol, Diazepam, Azithromycin is not revealed. Use with Theophylline attracts decrease in clearance of a tsetirizin. Myelotoxic drugs strengthen a gematotoksichnost of a tsetirizin. It is necessary to be careful at use of medicines which oppress TsNS.

Drug strengthens effects of alcohol therefore reception it is not admissible during treatment by this drug. Tsetirizin's use needs to be stopped three days before performance of allergy tests.

Terms of sale

It is released without recipe of the doctor.

Storage conditions

Temperature of storage is up to 25 °C.

Period of validity

3 years.

Tsetirizin at pregnancy

In the official instruction it is specified that drug is contraindicated at pregnancy. It is based that appropriate researches of women of this category were not conducted, however researches on animals did not reveal risks of negative impact on a fruit (category of risks for a fruit In on FDA). Also there are no data on allocation it with breast milk therefore you should not apply during feeding of the child.

Nevertheless, according to not numerous researches of drug concerning a possibility of use for pregnant women in the first trimester, it does not increase amount of inborn defects, frequency of misbirths and early childbirth. Also the weight of newborns whose mothers accepted Tsetirizin did not differ.

If there is a need of use of antiallergic drugs during pregnancy, then weighing all risks, it is necessary to prefer as Phencarolum, a tsetirizin and Loratadin which it is better not to appoint in the first trimester.

Tsetirizin's analogs

The analogs having one active ingredient: Zirtek, Tsetrin, Allertek, Zodak, Letizen, Parlazin.

Zdravzona

  • Tsetirizin of 10 mg No. 20 tabletkiverteks closed joint stock company
  • Tsetirizin Geksal of a drop 10mg/ml 20mlsalutas Pharma
  • Tsetirizin Geksal of 10 mg No. 10 tabletkisalutas Pharma
  • Tsetirizin-Tev of 10 mg No. 30 tabletkiteva Pharmaceutical
  • Tsetirizin of 10 mg No. 10 tabletkiverteks closed joint stock company

Drugstore of IFC

  • Tsetirizin-Tev tbl p/pl/o 10 mg No. 30, Tevaizrail
  • Tsetirizin tbl p/pl/o 10 mg No. 10, Zaorossiya's Vertexum
  • Tsetirizin-Akrikhin tbl p/pl/o 10 mg No. 20, Polfa/Warsaw Pharmaceutical Workspolsha
  • Tsetirizin tbl p/pl/o 10 mg No. 10 *, Zaorossiya's Vertexum
  • Levotsetirizin-Tev tbl p / about 5 mg No. 7, Teva/Pharmachemieniderlandy
to show still

Apteka24

  • Tsetirizinastrafarm (Ukraine, Cherry)

Paniapteka

  • Tsetirizin tab. p / about 10 mg No. 20
Section: From an allergy
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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