Cimetidinum

Циметидин Drug photo

The description is actual on 15.03.2015

  • Latin name: Cimetidine
  • ATH code: A02BA01
  • Active ingredient: Cimetidinum (Cimetidine)
  • Producer: Gedeon Richter (Hungary), LLC Farmlend (Belarus)

Structure

Active component Cimetidinum is a part of drug.

Additional components: magnesium stearate, povidone, starch corn, cellulose microcrystallic, talc and so on.

Release form

Cimetidinum in the form of tablets, capsules and solution for injections is issued.

Tablets and capsules are packaged on 10 pieces in strip packagings, on 10 packagings in a pack. Solution for injections is offered in ampoules.

Pharmacological action

Antiulcerous action is characteristic of Cimetidinum.

Pharmacodynamics and pharmacokinetics

This medicine is a blocker histamine H2 receptors of the I generation. At its reception production of hydrochloric acid is suppressed, increases rn that allows to reduce activity of pepsin.

Treatment by Cimetidinum promotes recovery of protective mechanisms mucous a stomach and to healing of various damages caused by influence of hydrochloric acid. There is it thanks to increase of production of gastric slime, increase in contents in it in glycoproteins, additional stimulation of secretion of a hydrocarbonate mucous a stomach and so on.

Besides, reduction of concentration of the recovered P450 cytochrome, considerable suppression of anilingidroksilazny activity of microsomal enzymes of a liver is noted. At the same time drug does not make impact on adrenoceptors, does not show mestnoanesteziruyushchy effect.

During treatment of the small tortoiseshell there is a blocking histamine H2 receptors in blood vessels of the integuments which are partially responsible for manifestation of inflammatory reactions. Also the anti-androgenic effect blocking dihydrotestosterone is characteristic of Cimetidinum that leads to tranzitorny increase of concentration of Prolactin – when the drug is administered struyno in / century.

Development of therapeutic action is noted an hour later, on condition of use of 300 mg of medicine, not less than 4-5 h remain.

In an organism there is a full absorption from a gastrointestinal tract. The metabolism occurs mainly in a liver therefore metabolites are formed: sulphoxide and hydroxymethyl Cimetidinum.

Distribution of Cimetidinum covers rather wide space in fabrics, communication with proteins of plasma makes nearly 20%. Removal of drug happens by means of kidneys, in not changed look.

Indications to use

As a rule, Cimetidinum is appointed at:

  • aggravations of a peptic ulcer of a stomach and 12-perstny gut;
  • symptomatic ulcers;
  • erosive and reflux esophagitis;
  • Zollingera-Ellison's syndrome;
  • to the heartburn connected with a hyperacidity;
  • prevention of ulcer aggravations, erosive cankers of upper parts of a gastrointestinal tract, recurrence of bleedings of this area, postoperative complications, system mastocytosis, polyendocrine adenomatosis.

Also drug can be appointed as additional therapy, for example: at insufficiency of enzymes of a pancreas, acute forms of the small tortoiseshell, a pseudorheumatism.

Contraindications to use

The main contraindication to purpose of Cimetidinum is existence of hypersensitivity to it and its components.

Side effects

At treatment the negative phenomena mentioning various bodies and systems, for example can arise Cimetidinum: digestive, nervous, endocrine, cardiovascular, urinary, musculoskeletal and hemopoiesis.

Therefore development is possible: nausea, vomitings, diarrheas, hepatitis, pancreatitis, jaundice, drowsiness, fatigue, depression, dizziness, nervousness, headache, gynecomastia, tachycardia, bradycardia, nephrite, mialgiya and so on.

Besides, different types of allergic reactions, for example, in a look can be shown: skin rash, itch, hyperemia, Quincke's disease, mnogoformny erythema, exfoliative dermatitis. Hair loss cases are also noted.

Application instruction of Cimetidinum (Way and dosage)

As the application instruction of Cimetidinum reports, the therapeutic scheme is established individually.

To adult patients of a tablet and capsule appoint 100-800 mg in an average one-time dosage.

The drug dosage in injections makes 200-400 mg. At long in infusions appoint 50-100 mg/h.

Anyway, irrespective of a type of introduction, the most admissible daily dose makes up to 2,4 g – to adult patients.

To children of 1 year the daily dosage of Cimetidinum is calculated taking into account body weight – 25-30 mg/kg, about one year – 20 mg/kg.

Overdose

It is established that use of drug in a dosage does not lead less than 20 g to development of adverse effects.

In other cases can arise: drowsiness, nausea, bradycardia, dryness in a mouth.

Treatment includes a gastric lavage – in the first 4 h if it is necessary to carry out a hemodialysis. Patients need continuous supervision and symptomatic therapy.

Interaction

During use of Cimetidinum with other medicines numerous medicinal interactions are shown.

It is especially necessary to refrain from a combination to analgetics, antiepileptic meansthe Carbamazepine, Phenytoinum and Valproatum, drugs influencing activity of cardiovascular system – Amiodaronum, Flekanid, Lignocainum, Prokainamid, Propafenon, Quinidine, beta-blockers, some blockers of calcium channels, antibacterial agentsMetronidazole and Erythromycin as Cimetidinum is capable to increase their plasma concentration.

Reception with anticoagulants increases anticoagulative effect of Warfarin and Nicoumalonum. Also this drug increases plasma concentration of Theophylline and Cyclosporine.

Terms of sale

In a drugstore Cimetidinum can be got according to the recipe issued by the doctor.

Storage conditions

Medicine is allowed to be stored, in the cool, dark and dry place unavailable to children.

Period of validity

4 years.

Analogs of Cimetidinum

Coincidence on the ATH code of the 4th level:

The main analogs of Cimetidinum are provided by drugs:

  • Cinametum, Tagametum, Belometum, Primamet, Altramet, Tsimetiget, Bezidin, Tsimedal, Gastromet, Simetidin, Tsimetar, Supramet, Tametin, Ultsedon, Ultseratil, Ulkomet, Zagastrol, Ximiesang, Neytronorm, Ulkometin, Tsimegeksal.

Alcohol

At treatment by Cimetidinum it is necessary to refuse the use of any alkogolsoderzhashchy means. Similar combinations are capable to strengthen effect of alcohol and to increase its keeping in composition of blood.

Section: Gastrointestinal
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