Ципринол Drug photo

The description is actual on 30.07.2014

  • Latin name: Ciprinol
  • ATH code: J01MA02
  • Active ingredient: Ciprofloxacin (Ciprofloxacin)
  • Producer: KRKA (Slovenia)


Tablets Tsiprinol monohydrate, silicon dioxide, croscarmellose sodium, sodium carboxymethylstarch, magnesium stearate, povidone, microcrystallic cellulose, propylene glycol, dioxide of titanium, talc have as a part of ciprofloxacin a hydrochloride.

As a part of solution Tsiprinol the following substances contain: ciprofloxacin lactate, sodium chloride, sodium lactate, Acidum hydrochloricum, water,

Release form

Drug is issued in the form of infusion solution. It is the transparent liquid having a yellowish-green shade.

Also the concentrate which is used for solution preparation is implemented. It is transparent or yellowish-greenish solution.

Tablets Tsiprinol 250 mg biconvex, have the round form, white color, slanted edges. They are covered by a film cover, on one party of a tablet there is a notch.

Tablets Tsiprinol 500 mg biconvex, have the oval form, white color. The tablet is covered by a film cover, on the one hand there is a notch.

Tablets Tsiprinol 750 mg have the oval form, have a film cover of white color, the notch is on both sides of a tablet.

Pharmacological action

Tsiprinol (ciprofloxacin) has antibacterial effect on an organism. It is monofluorinated ftorkhinolon the second generation. Under its influence topoisomerase II, enzyme which defines replication and biosynthesis of deoxyribonucleic acid of bacteria is inhibited. He takes active part in process of cell fission of bacteria and in biosynthesis of proteins.

Tsiprinol has bactericidal effect, he is most effective in relation to gram-negative bacteria. Therefore drug is used at treatment of the diseases caused by these bacteria.

Also some number of gram-positive bacteria are sensitive to Tsiprinol: Staphylococcus spp., Streptococcus spp. It influences also a number of intracellular microorganisms.

High performance of drug is noted at treatment of the infectious diseases provoked by a pyocyanic stick. Tsiprinol maloaktiven concerning chlamydias, anaerobe bacterias, mycoplasmas. Mushrooms, viruses, protozoa generally show resistance to effect of drug.

Pharmacodynamics and pharmacokinetics

Ciprinol in the form of tablets is quickly soaked up, getting into a gastrointestinal tract. Its absorption is not influenced by the use of food, its bioavailability at the same time does not decrease. Bioavailability equals 50–85%. The maximum concentration of active agent in blood of the patient is noted approximately in 1-1,5 hours after reception of tablets. After absorption active ingredient is distributed in fabrics urinogenital and respiratory tracts, in synovial fluid, muscles, skin, fatty tissues, in saliva, a phlegm, cerebrospinal liquid. Also it gets to cells (macrophages, neutrophils) that defines its efficiency at therapy of infectious diseases at which activators are localized intracellularly.

As a result of the biotransformation occurring in a liver low-active metabolites appear. Drug is removed from an organism through kidneys, and also by operation of extrarenal mechanisms (with excrements, with bile). Time of semi-removal of drug from an organism makes from 5 to 9 hours. Therefore, for effective therapy two times a day are enough to accept means.

After carrying out infusion intravenously of Tsiprinol's solution the maximum concentration is reached 1 hour later. At introduction active distribution in body tissues in which higher concentration of active ingredient in comparison with a blood plasma is noted is intravenously noted. Ciprofloxacin well gets through a placenta.

At people with normal functions of kidneys the elimination half-life of drug makes from 3 to 5 hours. At the patients having a renal failure, time of semi-removal increases till 12 o'clock.

After carrying out infusion drug is removed through kidneys. In an invariable look about 50-70% of drug are removed, another 10% are brought in the form of metabolites other quantity – through a digestive tract. With breast milk the small percent of active ingredient is allocated.

Indications to Tsiprinol's use

Ciprinol is appointed in need of treatment of infections which were provoked by microorganisms with high sensitivity to ciprofloxacin, from what at the person and a certain disease develops. Therefore, indications to medicine use the following:

  • infectious diseases of respiratory tracts: bronchitis, pneumonia, mucoviscidosis, bronchoectatic disease, etc.;
  • infectious LOR-diseases: otitis, mastoiditis, sinusitis;
  • infectious diseases of urinary tract and kidneys: cystitis, urethritis, pyelonephritis;
  • infectious illnesses of generative organs, and also other bodies of a small pelvis: prostatitis, epididymite, endometritis, clamidiosis, salpingitis, etc.;
  • infectious illnesses of abdominal organs: cholecystitis, a cholangitis, intraperitoneal abscess, the diarrhea developing owing to an infection, etc.;
  • infections of integuments and soft tissues: ulcers, burns and wounds of an infectious origin, phlegmon, abscesses;
  • infectious diseases of a musculoskeletal system: septic arthritis, osteomyelitis;
  • development of sepsis, infections in people with the broken immunity;
  • preventive measures for the prevention of development of infections at surgical and orthopedic operations;
  • therapy and prevention of a pulmonary form of a malignant anthrax.


It is impossible to appoint Tsiprinol at the following diseases and states:

  • high level of sensitivity to the ciprofloxacin, other HP relating to group of ftorkhinolon or to any other components of means.
  • pregnancy and time of feeding;
  • age till 18 flyings (except for treatment of the complications provoked by Pseudomonas aeruginosa children have from 5 to 17 years which are ill a mucoviscidosis of lungs; also it is used for therapy and prevention of a malignant anthrax at children);
  • it is impossible to use drug in at one time with Tizanidin.

With care Tsiprinol sick with the expressed atherosclerosis of vessels of a brain, disturbances of a blood-groove in a brain, and also to the people having epilepsy, mental diseases, a renal or liver failure is appointed. It is necessary to control accurately a condition of elderly people who receive medical treatment for drug, and also those at whom the lack of a glyukozo-6-phosphate-dehydrogenase is noted.

Side effects

  • Alimentary system: complex of the dispepsichesky phenomena, anorexia, gepatonekroz, hepatitis, cholestatic jaundice, pseudomembranous colitis.
  • Central nervous system: headache, migraine, high level of fatigue and uneasiness, faints, spasms, tremor, excitement, increase of VChD, depression, disturbances of consciousness, hallucination, other psychotic reactions.
  • Sense bodys: vision disorders, sense of smell, hearing, periodic emergence of a sonitus.
  • Cardiovascular system: problems with a heart rhythm, tachycardia, lowering of arterial pressure, periodic rushes of blood to the person.
  • System of a hemopoiesis: anemia, leukopenia, thrombocytopenia, granulocytopenia, thrombocytosis, leukocytosis.
  • Urinary system: crystalluria, hamaturia, glomerulonephritis, polyuria, dysuria, albuminuria, bleedings, nephrite, decrease in azotovydelitelny functions of kidneys.
  • Displays of an allergy: urticaria, itch of skin, emergence of blisters and bleeding, dot hemorrhages, medicinal fever, hypostases, vasculitis, nodal erythema, dieback, etc.
  • Musculoskeletal system: arthritis, arthralgia, ruptures of sinews, tendovaginitis, mialgiya, hypostases.
  • Other manifestations: candidiasis, light sensitivity, perspiration, condition of the general weakness.
  • On laboratory indicators: increase in activity of hepatic transaminases and ShchF, prothrombinopenia, hyperuricemia, giperkreatininemiya, hyperbilirubinemia, hyperglycemia.
  • At infuzivny introduction local reactions can appear.

Application instruction of Tsiprinol (Way and dosage)

Both intravenous administration of solution Tsiprinol, and Ciprinol 500 mg (in tablets) is appointed two times a day. At easy forms of infectious diseases urinary or respiratory tracts, and also at diarrhea the single dose of drug of 250 mg is appointed. At severe forms of diseases or at the complicated infections of the patient has to accept 500 or 750 mg of drug.

The instruction on Tsiprinol of 500 mg provides that at gonorrhea drug is accepted in this dose once. If intravenous administration of means practices, it is necessary to carry out slow infusion, at the same time the dose of drug is equal to 200-400 mg. If acute gonorrhea is diagnosed for the patient, to him 100 mg of Tsiprinol are once intravenously entered. For the purpose of prevention of postoperative infectious complications approximately for 1 h prior to the beginning of surgical intervention to the patient 200-400 mg of Tsiprinol are entered.

If at the patient disturbance in work of kidneys is noted, then the daily dose of HP for oral administration is reduced twice.

It is necessary to drink tablets before food, at the same time it is important to wash down drug with a large amount of water.


At overdose manifestation of a number of symptoms can be noted: dizziness, headache, vomiting, nausea, diarrhea. In case of strong overdose disturbances of consciousness, a tremor, spasms, display of hallucinations are possible.

Symptomatic therapy is carried out, it is important to provide to the patient receipt of enough liquid, to carry out a gastric lavage. Also purgatives, absorbent carbon are appointed.


If at the same time to carry out treatment by Tsiprinol and Didanozin, then decrease in absorption of ciprofloxacin is noted.

Under the influence of ciprofloxacin concentration increases and the elimination half-life from an organism of theophylline and other xanthines increases.

At parallel treatment by ciprofloxacin and peroral hypoglycemic means, and also indirect anticoagulants the prothrombin ratio decreases.

Development of spasms at a concomitant use of ciprofloxacin and NPVS is possible.

Absorption of ciprofloxacin can decrease at parallel treatment antacids, in HP which contain ions of aluminum, iron, zinc, magnesium. It is important to provide the interval between reception of these drugs making not less than 4 hours.

If ciprofloxacin and cyclosporine is at the same time applied, then nephrotoxic influence of the last amplifies.

Metoclopramidum activates ciprofloxacin absorption. As a result, the period of achievement of its greatest concentration in plasma decreases.

At treatment ciprofloxacin and uricosuric drugs slow down removal of ciprofloxacin and its concentration in plasma increases.

At a concomitant use with other drugs having antimicrobic effect, as a rule, the synergism is noted.

Terms of sale

Tsiprinol is implemented in drugstores according to the recipe.

Storage conditions

It is necessary to store HP in the dry, dark place, at the same time temperature should not be above 25 °C.

Period of validity

5 years can be stored.

Special instructions

To the people having spasms, epilepsy, diseases of vessels and organic diseases of a brain, ciprofloxacin can be appointed only in the presence of vital indicators.

If in the course of therapy long diarrhea in a severe form is noted it is necessary to exclude pseudomembranous colitis. At confirmation of such diagnosis it is necessary to cancel urgently drug and to carry out treatment of the patient.

If sinew pains are noted, and also the first symptoms of a tendovaginitis, the course of treatment stops as at treatment of a ftorkhinolonama cases of an inflammation and a rupture of sinews were noted.

It is not necessary to practice serious exercise stresses during therapy by ciprofloxacin.

It is impossible to exceed an admissible daily dosage as the risk of manifestation of a crystalluria increases. To support the normal level of diuresis, it is important to accept enough liquid during treatment.

At treatment by drug it is impossible to allow strong UF-radiation.

At the people suffering from deficit of a glyukozo-6-phosphate-dehydrogenase at Tsiprinol's appointment hemolitic anemia can be shown.

At treatment by an antibiotic it is necessary to drive carefully transport and to make other operations connected with special attention.


Tseprova, Tsiprobay, Kvintor, Tsiploks, Tsiprobid, Tsiprolet, Tsifran, Tatsip.

The analogs having similar action it is drugs Tsiprovin, Tsiprrosan, Tsiprolon, Tsipropan, Tsiprokvin, Tariferid, Sifloks, Perti, Renor, Oflomak, Norilet, Oflotsid, Negafloks, Norfatsin, etc. All listed analogs can be appointed only after approval of the doctor. About what drug it is reasonable to choose, and also an antibiotic it or not, it is necessary to ask the treating specialist surely.

With antibiotics

Tsiprinol's combination with a ceftazidime and azlotsilliny is allowed at treatment of the diseases provoked by Pseudomonas spp. at treatment of streptococcal infections the combination with mezlotsilliny, azlotsilliny, others beta laktamnymi antibiotics is allowed. At treatment of staphylococcal infections means is combined with Vancomycinum and izoksazolpenitsillina. At therapy of mephitic gangrenes the combination with metronidazole and clindamycin is allowed.

With alcohol

It is forbidden to take alcoholic beverages in the course of treatment by Tsiprinol.

To children

Drug can be appointed for treatment of children and teenagers till 18 flyings only in need of therapy and prevention of a malignant anthrax, and also at treatment of the complications provoked by Pseudomonas aeruginosa at the children who are ill a mucoviscidosis of lungs.

At pregnancy and a lactation

It is impossible to appoint Tsiprinol for treatment of pregnant women, and also nursing mothers. Breastfeeding needs to be stopped at once.

About Tsiprinole

Responses of patients demonstrate that by means of Tsiprinol they managed to overcome an infection which provoked a disease. Nevertheless, there are many reviews of manifestation of side effects in the course of therapy. In particular, it is mentioned dysbacteriosis, fungal infections, deterioration in laboratory indicators of blood. It is noted that the antibiotic needs to be accepted throughout that period which was appointed by the doctor.

Tsiprinol's price where to buy

The cost of tablets Tsiprinol of 250 mg averages 70 rub for 10 pieces. The price Tsiprinol of 500 mg averages 120 rub for 10 pieces. The price Tsiprinol solution for infusions – from 90 to 100 rub for 100 ml.


  • Tsiprinol a concentrate for solution 100mg/10ml 10 of ml No. 5 ampulykrka
  • Tsiprinol of 500 mg No. 10 tabletkikrka
  • Tsiprinol of 250 mg No. 10 tabletkikrka
  • Tsiprinol solution for infusions 2mg/ml 100mlkrka
  • Tsiprinol of 750 mg No. 10 tabletkikrka

Drugstore of IFC

  • Tsiprinol tbl p / about 500 mg No. 10, Krkasloveniya
  • Tsiprinol tbl p / about 250 mg No. 10, Krkasloveniya
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  • Tsiprinolkrka (Slovenia)
  • Tsiprinolkrka (Slovenia)
  • Tsiprinolkrka (Slovenia)
  • Tsiprinolkrka (Slovenia)
  • Tsiprinol of a tablet 750 of mg No. 10KPKA (Slovenia)


  • Tsiprinol solution d/in.100mg/10ml amp. No. 5KPKA
  • Tsiprinol solution d/in.100mg/10ml amp. No. 5KPKA
  • Tsiprinol solution d/in.100mg/10ml amp. No. 5KPKA
  • Tsiprinol solution d/in.100mg/10ml amp. No. 5KPKA
  • Tsiprinol solution d/in.100mg/10ml amp. No. 5KPKA
Section: Antibiotics
in more detail

Education: "Pharmacy" graduated from the Rovno state basic medical college majoring in. Graduated from the Vinnytsia state medical university of M. I. Pirogov and internship on its base.

Experience: From 2003 to 2013 – worked at positions of the pharmacist and manager of a pharmaceutical booth. It is awarded by diplomas and distinctions for long-term and honest work. Articles on medical subject were published in local editions (newspaper) and on various Internet portals.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Tsiprinol surely consult with the attending physician.