Tsitikolin

Цитиколин Constitutional formula

The description is actual on 19.12.2015

  • Latin name: Citicolinum
  • ATH code: N06BX06
  • Chemical formula: C14H27N4O11P2
  • CAS code: 987-78-0

Chemical name

5 ′-O-[hydroxy ({ hydroxy [2-(trimetilammonio) etoks] phosphoryl } oks) phosphoryl] cytidine

Chemical properties

Tsitikolin – nootrop and the psychostimulant increasing density of dopamine and atsetilkholinovy receptors. This substance is an intermediate link in reaction of formation of phosphatidylsincaline from sincaline. The molecular mass of connection = 489,3 grams on mol. Medicine is let out in the form of solution for intravenous or intramuscular administration or liquid for intake.

Pharmacological action

Neurometabolic, nootropic.

Pharmacodynamics and pharmacokinetics

Tsitikolin, being a predecessor of ultrastructural components of a cellular membrane, namely – phospholipids, possesses enough broad spectrum of activity. Drug recovers the damaged membranes of cells, inhibits effect of enzymes phospholipases, prevents excessive education of free radicals. Thanks to this medicine it is possible to prevent or to considerably reduce intensity of death of cells, exerting impact on apoptosis mechanisms.

At use of drug in the acute period of a stroke, it reduces the volume of the damaged fabric, stimulates cholinergic transfer. Drug promotes fast recovery after craniocereberal injuries, reduces duration of a posttraumatic coma, neurologic symptoms are shown with smaller intensity.

At patients with a chronic hypoxia of a brain drug is rather effective at treatment of cognitive frustration, deteriorations in processes of storing and difficulties with self-service. Under the influence of this substance the level of consciousness and attention increases, to the patient memory returns. Also substance is rather effective at treatment of motive and neurologic disturbances of a vascular or degenerative etiology.

Tsitikolin has a good absorbing capacity, both at injection, and at oral administration. Medicine possesses high biological availability. The metabolism of means is carried out in liver tissues, with formation of cytidine and sincaline. Substance is evenly distributed on various structures of a brain, actively built in membranes of mitochondrions, cells, cytoplasms with formation of parts of fractions of structural phospholipids.

About 15% of the means accepted or entered by means of an injection are brought out of an organism. Allocation happens by means of kidneys, however, mainly – to the exhaled carbon dioxide. The first phase of excretion through kidneys occurs within 36 hours, practically all medicine is during this time removed. For breath this indicator makes 15 hours.

Indications to use

Tsitikolin of sodium appoint:

  • in the acute period of an ischemic stroke;
  • at recovery after the had hemorrhagic or ischemic stroke;
  • to patients with craniocereberal injuries during the recovery and acute periods;
  • for elimination of cognitive disturbances at vascular and degenerative diseases of a brain.

Contraindications

Means is not used:

  • in pediatric practice;
  • in the presence of reactions of hypersensitivity to Tsitikolin;
  • if at the patient the tone of parasympathetic part of a vegetative nervous system prevails (vagotonik).

Side effects

Side reactions when using drug arise seldom.

Can be shown:

  • disturbances of a sleep pattern, dizziness, tremor, headaches, overexcitement;
  • numbness of extremities, appetite loss, nausea, growth of activity of enzymes of a liver;
  • anaphylactic reactions, enanthesis, allergic itch;
  • seldom – hypotension or hypertensia, hyper stimulation of a parasympathetic nervous system.

If the specified side reactions are aggravated, there are unusual symptoms and side effects, then it is recommended to consult with the attending physician.

Application instruction of Tsitikolin (Way and dosage)

Solution for intravenous or intramuscular administration is used in the dosage depending on indications.

Intravenous injections make not less than 3 minutes, it is better to pour in medicine kapelno with a speed from 40 to 60 thaws a minute. The intramuscular way of introduction is used less often. At such injections medicine it is necessary to enter every time into the new place.

The application instruction of Tsitikolin in the acute period of a craniocereberal injury or ischemic stroke

Enter on 1 gram of drug each 12 hours, at once after the diagnosis was made. It is necessary to carry out treatment not less than 6 weeks. If at the patient normal deglutitory function remained, it is recommended to pass to a peroral form of medicine within 3-5 days after the beginning of therapy.

During the recovery period appoint from 0,5 to 2 grams of drug a day. The mode of dosing and duration of treatment are defined in an individual order by the attending physician.

Correction of a dosage for elderly persons is not required. After opening of an ampoule its contents needs to be used immediately. Medicine can be implicated in one syringe or infusional system with all types isotonic a ditch and dextrose solution.

The instruction on solution for peroral use

Medicine can be parted in a small amount of water. It is recommended to drink means to food or during meal. As a rule, appoint from 200 to 300 mg of medicine 3 times a day. The course of treatment is defined depending on efficiency of therapy and a condition of the patient.

Overdose

Tsitikolin possesses a hypotoxicity, his overdose is improbable.

Interaction

Substance is not recommended to be combined with the medicines incorporating Meclofenoxatum.

Drug strengthens effects of L-dihydroxyphenylalanin.

Terms of sale

The recipe is necessary.

Storage conditions

Store medicine at a temperature not higher than 30 degrees, far from small children.

Period of validity

2 or 3 years, depending on the producer.

Special instructions

During treatment it is necessary to be careful when driving or other vehicles.

If in the course of storage at low temperatures in solution crystals, drug, after full dissolution of crystals were formed, it is possible to use for injection introduction.

To children

Medicine is not used in pediatric practice.

Widespread analogs of Tsitikolin: Tserakson, Lira, Tsitikolina monosodium salt, Neypilept, Tsitikolin of sodium.

Responses

Some About drug:

  • "… The father after a stroke began to take medicine. Propyl its about 3 months. Now noticeable improvements in a state are visible, numbness of a hand took place, small motility, memory improved and a physical activity increased. Good drug, however, it was sometimes complex to be got and costs expensive";
  • "… After mine the uncle had an accident, received ChMT and it was discharged from hospital, to it appointed Tsitikolin's course to a month. At first in pricks, then – in syrup. The uncle well transferred treatment, now he feels much better. Drug expensive, but effective";
  • "… Solution for intake was appointed by the neurologist to my child (an inborn injury, a cyst in a brain). The daughter transferred drug badly, did not sleep at night, there was a hyper tone of legs and a back, the child constantly was capricious. As a result, after visit of other doctor passed to other medicine".

Tsitikolin's price where to buy

Tsitikolin's price in the form of solution for intake Tserakson makes about 700-800 rubles for 30 ml a bottle, a dosage of 100 mg on 1 ml. Tserakson's cost for intravenous administration – about 1100-1200 rubles, 5 ampoules on 4 ml (1 gram of active ingredient).

Section: Active ingredients
PAY ATTENTION! Information on active ingredients on the website is help generalizing, collected from public sources and can form the basis for making decision on use of these substances it is not aware of treatment. Before substance use Tsitikolin surely consult with the attending physician.