Citrulline

Цитруллин Drug photo

The description is actual on 23.09.2015

  • Latin name: Citrulline malate
  • ATH code: A16AA07
  • Active ingredient: Citrulline malate
  • Producer: WIRUD GmbH (Germany), primaFORCE (USA)

Structure

About 57% of L-citrulline and about 43% of DL malate.

Release form

Citrulline malate is implemented in the form of raw materials for production of various dietary supplements. It represents white or almost white color crystal powder with sourish taste which is well dissolved in water. In packaging there can be 100 g, 200 g of raw materials.

Pharmacological action

The expressed all-tonic, anti-asthenic, adaptogenny influence normalizing exchange processes.

Pharmacodynamics and pharmacokinetics

l-citrulline – is replaceable amino acid, it is capable to provide natural production of arginine in an hour after reception and for the subsequent 20 h. Besides:

  • provides a pamping;
  • supports positive nitrogenous balance of an organism, removes ammonia and lactic acid;
  • increases muscular endurance (recovers reserves of ATP and creatine phosphoric acid);
  • strengthens immune system and increases an energy potential of all organism.

Pharmacokinetics

L-citrulline is soaked up mainly in a gastrointestinal tract, the dose of 0,18 g/kg causes doubling of plasma and fabric concentration of arginine, and also increase in plasma concentration of the citrulline at 6-11 times. The metabolism occurs thanks to enzymes arginosuktsinat to synthase and arginosuktsinat to lyase and leads to formation of L-arginine in nearby vessels.

Indications to use

Symptomatic treatment of an adynamy of various type, including functional, sexual, at athletes, and also overfatigue and fatigue.

Besides, the postoperative period is applied in the course of recovery, at pregnancy and at advanced age.

Contraindications

Hypersensitivity to citrulline to malate.

Side effects

Unpleasant feelings in the field of an epigastr at the beginning of therapy, and also allergic reactions are possible.

Citrulline, application instruction (Way and dosage)

For elderly and adult

The one-time dose for oral administration inside makes 200 mg, the frequency of reception should not exceed 1-3 times a day, therapy duration — till 12 days.

For children

Till 5 flyings: a daily dose – 200 mg for 1 reception.

From 5 to 15 years — 400 mg for 2 receptions.

Use in sport and bodybuilding

It is necessary to take 5-10 g with liquid — in time and before training (for 0,5 h), and also before going to bed. It is desirable, on a hungry stomach.

Overdose

There are no data.

Interaction

Data were not provided by the producer.

Terms of sale

Citrulline in a drugstore is on sale without recipe.

Storage conditions

Dry, cool (it is not higher than +25 °tselsiya) the place which has to be out of access for children.

Period of validity

It is possible to apply during 2 flyings of the date specified on bank.

Analogs

The most known structural analog — Stimol.

About Citrulline

The patients ordering the drugs and dietary supplements containing citrulline are concerned first of all by the content of active agent as reception less than 6 g a day can not give the expected positive effect. Therefore experienced specialists before use recommend to get acquainted with amount of active agent in the grams specified on packaging and to define a dose of a one-time portion of the used food additive.

Section: Dietary supplements
in more detail

Education: Graduated from the Nikolaev national university of V. A. Sukhomlinsky, gained the diploma of the specialist with honors as "An embryologist, a cytologist, a histologist". Also, the human physiology and animals, the teacher of biology" graduated from a magistracy majoring in ". The course on discipline "Pharmacology" is with honors passable.

Experience: Worked as the senior laboratory assistant of department of Physiology and biochemistry of the Nikolaev national university of V. A. Sukhomlinsky in 2010 - 2011.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Citrulline surely consult with the attending physician.