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1 sparkling tablet contains in the structure active agent acetylsalicylic acid in number of 500 mg, and also additional components: citric acid, aspartame, carbonate and hydrosodium carbonate, povidone, krospovidon, sodium citrate, fragrance.
Non-steroidal anti-inflammatory drug.
Pharmacodynamics and pharmacokinetics
The principle of action Upsarin is based by UPSA on not selective decrease of the activity of the cyclooxygenases 1 and 2 taking active part in synthesis of prostaglandins (create a pain syndrome and puffiness in an inflammation zone).
The medicine possesses anesthetic, antiinflammatory, moderately expressed febrifugal by effects.
Active agent is acetylsalicylic acid. At decrease in concentration of prostaglandins in the field of thermal control body temperature due to the strengthened sweating and expansion of a gleam of blood vessels decreases. The Analgeziruyushchy effect is reached central and peripheral by effects of acetylsalicylic acid. Medicine suppresses synthesis of A2 thromboxane in platelet cells, reducing a thrombogenesis, adhesion and aggregation of thrombocytes. After a single dose of Upsarin Ups the reached antiagregantny effect can remain for seven days (expressiveness of this effect stronger at males in comparison with women).
The medicine reduces risk of development of a myocardial infarction and an indicator of a lethality when diagnosing an unstable form of stenocardia. It is effectively applied at predisposed persons to primary and secondary prevention of a myocardial infarction. In a dose of 6 grams a day raises an indicator of a prothrombin time and at the same time suppresses formation of a prothrombin in hepatic system.
Upsarin UPSA is capable to reduce level vitamin of K-dependent coagulant factors (2,7,9,10), raises an indicator of fibrinolitic activity of plasma. Against treatment by a medicine the risk of bleedings and hemorrhagic complications when carrying out operative measures considerably increases.
Due to disturbance of a reabsorption of uric acid acetylsalicylic acid stimulates its removal in tubules of renal system.
Medicine reduces activity of gastroprotektorny (protective) prostaglandins, blocks cyclooxygenase-1 that can be the cause for an ulceration of a mucous wall of a stomach with the subsequent bleeding. The preference is recommended to be given to dosage forms which contain a special kishechnorastvorimy cover, buffer substances.
The additional form of a medicine – Upsarin of UPSA with vitamin C is issued. It is complex drug which contains ascorbic and acetilsalicylic acids. Vitamin C takes active part with oxidizing and recovery processes, regulates coagulability of blood, process of synthesizing of various substances and carbohydrate metabolism. Ascorbic acid makes the expressed antioxidant impact and raises regenerative opportunities of fabrics.
Indications to use Upsarin UPSA
From what tablets are appointed?
Medicine Upsarin is used by UPSA for stopping of moderately expressed feverish syndrome which accompanies many diseases of infectious and inflammatory character.
At an unstable form of stenocardia, a bezbolevy form of ischemia of a myocardium, at a myocardial infarction, when diagnosing at once of several risk factors of coronary heart disease, after prosthetics of heart valves, after coronary balloon angioplasty, after installation of a special stent, at an aortoarteriita, at defeats of coronary arteries of not atherosclerotic genesis, at a prolapse of the mitral valve, Dressler's syndrome, acute thrombophlebitis, a heart attack easy Upsarin UPSA is appointed as antiagregantny means in a daily dose to 300 mg.
Various hemorrhagic diathesis (Werlhof's disease, hemophilia, prothrombinopenia, teleangiectasia, angiohemophilia), existence of "an aspirinovy triad" (simultaneous diagnosing of a recurrent form polypose of a nose and adjacent bosoms, bronchial asthma and intolerance of drugs of a pyrazolon row, acetylsalicylic acid).
Medicine is not appointed at erosive and ulcer pathology of mucous walls of a digestive tract (an acute stage, an aggravation), at intolerance of active component, deficit of vitamin K, incubation of the pregnancy expressed to pathology of a liver and renal system.
Use Upsarin UPSA when feeding by a breast contraindicated.
At cankers of the alimentary system in the anamnesis, at the HSN dekompensirovanny form, gout, a hyperuricemia, a nefrourolitiaza (an uratny form) Upsarin UPSA apply with care (additional consultation of specialists is required), estimating possible risks and the remote effects.
As a result of the gaptenovy mechanism "aspirinovy asthma" and "an aspirinovy triad" forms (includes a simultaneous combination a polypose of a nose, adjacent bosoms, bronchial asthma and intolerance of drugs of a pyrazolon row and acetylsalicylic acid).
Medicine can cause disturbances in work of kidneys and hepatic system. Long therapy causes vomiting, dizzinesses, hypocoagulation, intersticial nephrite, a bronchospasm, erosive cankers of the alimentary system (a stomach, a duodenum), a sonitus, disturbances of visual and acoustical perception, a papillary necrosis, a prerenalny azotemia with a hypercalcemia and the increased content of creatinine, strengthening of expressiveness of clinical symptomatology HSN, aseptic meningitis, a nephrotic syndrome, puffiness.
Upsarin UPSA, application instruction (Way and dosage)
Treatment of acute rheumatism: the daily dose is calculated according to the scheme of 100 mg on 1 kg of weight a day, frequency rate of reception of 5-6 times a day.
Pain and feverish syndrome: 500-100 mg a day divided into three receptions. Therapy course no more than two weeks.
How to accept Upsarin UPSA: a sparkling pill is recommended to be taken after meal, previously having dissolved in water (100-200ml), 3-4 times a day. Duration of therapy can vary from 1 day to several months. Accept 150-250 mg of acetylsalicylic acid a day from what rheological properties of blood improve.
According to the application instruction Upsarin UPSA, to the patients who had a myocardial infarction and also for secondary prevention is recommended to accept daily 40-325 mg of drug (the average dose makes 160 mg). For inhibition of aggregation of platelet cells appoint 300-325 mg of a medicine daily.
Route of administration Upsarin UPSA at cerebral thromboembolisms, at dynamic changes in cerebral circulation: the initial dose – 325 mg a day, further is recommended gradual increase in amount of drug up to 1000 mg a day. Reception of 125-300 mg a day provides prevention of recurrence. Reception of 325 mg of acetylsalicylic acid through a special gastric tube (is established intranazalno) provides each seven hours prevention of occlusion of the aortal shunt and its thrombosis. Further it is recommended to pass to peroral forms of a medicine: three times a day in a dose of 325 mg in complex therapy with Dipiridamolum within a week.
It is shown by the central hyperventilation of lungs, bleedings, an anury, a respiratory alkalosis, a collapse, drowsiness, a metabolic acidosis and confusion of consciousness.
At an initial stage hyperventilation of lungs conducts to a respiratory alkalosis: cyanosis of extremities and body, asthma, short wind, emergence of a cold, clammy sweat. Further as a result of strengthening of intoxication respiratory paralysis and full dissociation in oxidizing phosphorylation develops that finally conducts to respiratory acidosis.
At poisoning provocation of vomiting, purpose of purgatives, enterosorbents, absorbent carbon is recommended. Control over indicators of electrolytic balance is obligatory. If necessary enter solution of a lactate, citrate or hydrosodium carbonate.
It is possible to strengthen removal of acetylsalicylic acid by means of increase of reserve alkalinity. It is not recommended to apply acetazoleamide to alkalization of urine (possibly development of an acidemia, strengthening of toxic influence of acetylsalicylic acid).
At elderly people intensive infusional care can lead to a fluid lungs that needs to be considered at treatment of intoxication Upsariny UPSA.
Hemodialysis appoint more than 100-130 mg of % at medicine level.
At edematization of lungs appoint carrying out artificial ventilation of the lungs the special mix rich with oxygen.
Upsarin of UPSA increases concentration of salts of lithium, barbiturates and digoxin in a blood plasma.
Etanolsoderzhashchy medicines, glucocorticosteroids, ethanol strengthen the irritating influence of acetylsalicylic acid on mucous walls of a digestive tract (the probability of gastrointestinal bleedings significantly increases).
Medicine increases efficiency of Reserpinum, non-steroidal anti-inflammatory drugs, trombolitik, anticoagulants of indirect action, streptocides (for example, Ko-Trimoksazol), narcotic analgetics, inhibitors of aggregation of platelet cells, hypoglycemic means (peroral forms).
The medicine strengthens toxic influence of a methotrexate.
The application instruction Upsarin UPSA is not recommended to appoint a medicine along with diuretic (veroshpiron, furosemide), hypotensive, uricosuric means (Sulfinpyrazonum, benzbromaron).
Speed and quality of absorption of acetylsalicylic acid decrease at reception of antiacid means in which structure salts of magnesium, aluminum descend.
Terms of sale
The recipe is not required.
In the place, dry, unavailable to children, at a temperature no more than 30 degrees Celsius.
Period of validity
No more than three years.
Prolonged treatment by drug Upsarin of UPSA demands obligatory control over the main indicators of a condition of blood, regular research a calla on the occult blood.
When using drug as an anesthetic it is possible to accept acetylsalicylic acid not longer than week. It is possible to apply medicine to achievement of febrifugal effect no more than three days.
Full refusal of salicylates in 7 days prior to the planned operative measure is recommended. Upsarin's use to UPSA in pediatric practice at viral pathology is contraindicated because of risk of development of a syndrome to Reja (increase in the sizes of a liver, forming of acute encephalopathy, pernicious vomiting).
Careful crushing of tablets, reception of a medicine after food, use of kishechnorastvorimy forms of acetylsalicylic acid, use of medicines which neutralize a hyperoxemia of a gastric juice allow to reduce the irritating drug influence Upsarin of UPSA by mucous walls of a digestive tract.
Medicine can provoke a new attack of gout at predisposed persons. Such influence is explained by decrease in amount of the removed uric acid at treatment by a medicine.
Acetylsalicylic acid is emitted with breast milk, increasing risk of bleedings at babies because of functional changes in platelet blood cells.
Teratogenic influence of a medicine is shown by a hypertension in a "small" circle of blood circulation, a hyperplasia of vessels of pulmonary fabric, premature closing of a gleam of an arterial channel.
Upsarin UPSA at pregnancy leads drug use to forming of malformations (splitting of the upper sky) in the first trimester, and reduces the speed of patrimonial activity in the third trimester due to braking of synthesis of prostaglandins.
Coincidence on the ATH code of the 4th level:
Analogs it is possible to call drugs: Asafen, Aspeter, Aspirin, Acetylsalicylic acid, Asprovit.
About Upsarin UPSA
According to responses, drug is effective according to indications at implementation of the application instruction.
The price Upsarin of UPSA where to buy
Packaging of medicine in 16 tablets is on sale at the price in 200 rubles.
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